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Literature summary for 1.1.1.205 extracted from
- Human IMP dehydrogenase. Kinetics and regulatory properties (1974), Biochim. Biophys. Acta, 364, 209-217.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 6-mercaptopurine ribonucleotide | - |
Homo sapiens |  |
| allopurinol ribonucleotide | - |
Homo sapiens | |
| AMP | - |
Homo sapiens | |
| GMP | - |
Homo sapiens | |
| additional information | inhibition by purine and pyrimidine compounds | Homo sapiens | |
| Mycophenolic acid | - |
Homo sapiens | |
| xanthosine 5'-phosphate | competitive with respect to IMP | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.014 | - |
IMP | - |
Homo sapiens | |
| 0.046 | - |
NAD+ | - |
Homo sapiens | |
| 17 | - |
K+ | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | monovalent cation required for maximal activity | Homo sapiens | |
| NH4+ | K+ can be partially replaced by NH4+ | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| IMP + NAD+ + H2O = XMP + NADH + H+ | ordered sequential mechanism | Homo sapiens | |
| IMP + NAD+ + H2O = XMP + NADH + H+ | IMP binds first, XMP is released last | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| placenta | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| inosine 5'-phosphate + NAD+ + H2O | - |
Homo sapiens | xanthosine 5'-phosphate + NADH | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.03 | - |
xanthosine 5'-phosphate | - |
Homo sapiens | |
| 0.1 | - |
GMP | - |
Homo sapiens | |
| 0.53 | - |
AMP | - |
Homo sapiens | |
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