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Literature summary for 1.1.1.205 extracted from

  • Hampton, A.; Brox, L.W.; Bayer, M.
    Analogs of inosine 5-phosphate with phosphorus-nitrogen and phosphorus-sulfur bonds. Binding and kinetic studies with inosine 5-phosphate dehydrogenase (1969), Biochemistry, 8, 2303-2311.
    View publication on PubMed
Search for more literature for 1.1.1.205

Inhibitors

Inhibitors Comment Organism Structure
5'-thio-IMP competitive inhibitor Klebsiella aerogenes
6-thioinosine 5'-phosphate in absence of glutathione Klebsiella aerogenes
xanthosine 5'-phosphate product inhibitor Klebsiella aerogenes

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.013
-
 5'-mercapto-5'-deoxyinosine 5'-S-phosphate
-
 Klebsiella aerogenes
0.038
-
 5'-Amino-5'-deoxyinosine 5'-N-phosphate
-
 Klebsiella aerogenes
0.21
-
 Inosine 5'-phosphorothioate
-
 Klebsiella aerogenes

Organism

Organism UniProt Comment Textmining
Klebsiella aerogenes
-
-
-

Reaction

Reaction Comment Organism Reaction ID
IMP + NAD+ + H2O = XMP + NADH + H+ enzyme acts on the hydroxyl group of the hydrated derivative of the substrate, ordered bi-bi mechanism Klebsiella aerogenes
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-amino-5'-deoxyinosine 5'-N-phosphate + NAD+ + H2O
-
 Klebsiella aerogenes 5'-amino-5'-deoxyxanthosine 5'-N-phosphate + NADH
-
 ?
5'-mercapto-5'-deoxyinosine 5'-S-phosphate + NAD+ + H2O
-
 Klebsiella aerogenes 5'-mercapto-5'-deoxyxanthosine 5'-phosphate + NADH
-
 ?
inosine 5'-phosphate + NAD+ + H2O
-
 Klebsiella aerogenes xanthosine 5'-phosphate + NADH
-
 ?
inosine 5'-phosphorothioate + NAD+ + H2O
-
 Klebsiella aerogenes xanthosine 5'-phosphorothioate + NADH
-
 ?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Klebsiella aerogenes