Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GMP | feedback inhibitor; feed-back inhibitor eliciting 'allosteric' kinetics of the enzyme, determination of the GMP binding site | Salmonella enterica subsp. enterica serovar Typhimurium |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics | Salmonella enterica subsp. enterica serovar Typhimurium | |
additional information | - |
additional information | Km over the range of pH 7.3-8.5 | Salmonella enterica subsp. enterica serovar Typhimurium | |
0.02 | - |
inosine 5'-phosphate | pH 7.5, 22°C | Salmonella enterica subsp. enterica serovar Typhimurium |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
inosine 5'-phosphate + NAD+ + H2O | Salmonella enterica subsp. enterica serovar Typhimurium | the reaction is irreversible over the range of pH 5.5 to pH 8.8, step in guanylic acid biosynthesis | xanthosine 5'-phosphate + NADH | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial purification | Salmonella enterica subsp. enterica serovar Typhimurium |
partially by ammonium sulfate fractionation | Salmonella enterica subsp. enterica serovar Typhimurium |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
inosine 5'-phosphate + NAD+ + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | xanthosine 5'-phosphate + NADH | - |
ir | |
inosine 5'-phosphate + NAD+ + H2O | the reaction is irreversible over the range of pH 5.5 to pH 8.8, step in guanylic acid biosynthesis | Salmonella enterica subsp. enterica serovar Typhimurium | xanthosine 5'-phosphate + NADH | - |
ir | |
inosine 5'-phosphate + NAD+ + H2O | the reaction is irreversible over the range of pH 5.5 to pH 8.8 | Salmonella enterica subsp. enterica serovar Typhimurium | xanthosine 5'-phosphate + NADH | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
IMP-DH | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
IMP:NAD oxidoreductase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
inosine 5'-phosphate dehydrogenase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Salmonella enterica subsp. enterica serovar Typhimurium |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Salmonella enterica subsp. enterica serovar Typhimurium |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5.5 | 8.8 | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Ki over the range of pH 7.3 to 8.5 | Salmonella enterica subsp. enterica serovar Typhimurium |