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Literature summary for 1.1.1.203 extracted from

  • Parkkinen, T.; Boer, H.; Jaenis, J.; Andberg, M.; Penttilae, M.; Koivula, A.; Rouvinen, J.
    Crystal structure of uronate dehydrogenase from Agrobacterium tumefaciens (2011), J. Biol. Chem., 286, 27294-27300.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Agrobacterium tumefaciens

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structures of an apo-form, a ternary form in complex with NADH and product, and an inactive Y136A mutant in complex with NAD+. Enzyme is a homohexamer. The monomer contains a Rossmann fold, essential for nucleotide binding. The ternary complex structure reveals a product, D-galactaro-1,5-lactone, which is bound above the nicotinamide ring. This product rearranges in solution to D-galactaro-1,4-lactone Agrobacterium tumefaciens

Protein Variants

Protein Variants Comment Organism
Y136A inactive. Crystal structure shows changes in the position of residues Ile74 and Ser75. This probably alters the binding of the nicotinamide end of NAD+ Agrobacterium tumefaciens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-galacturonate + NAD+ + H2O Agrobacterium tumefaciens
-
D-galactarate + NADH + H+
-
?
D-galacturonate + NAD+ + H2O Agrobacterium tumefaciens C58 / ATCC 33970
-
D-galactarate + NADH + H+
-
?
D-glucuronate + NAD+ + H2O Agrobacterium tumefaciens
-
D-glucaric acid + NADH + H+
-
?
D-glucuronate + NAD+ + H2O Agrobacterium tumefaciens C58 / ATCC 33970
-
D-glucaric acid + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Agrobacterium tumefaciens Q7CRQ0
-
-
Agrobacterium tumefaciens C58 / ATCC 33970 Q7CRQ0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-galacturonate + NAD+ + H2O
-
Agrobacterium tumefaciens D-galactarate + NADH + H+
-
?
D-galacturonate + NAD+ + H2O
-
Agrobacterium tumefaciens C58 / ATCC 33970 D-galactarate + NADH + H+
-
?
D-glucuronate + NAD+ + H2O
-
Agrobacterium tumefaciens D-glucaric acid + NADH + H+
-
?
D-glucuronate + NAD+ + H2O
-
Agrobacterium tumefaciens C58 / ATCC 33970 D-glucaric acid + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
Udh
-
Agrobacterium tumefaciens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Agrobacterium tumefaciens