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Literature summary for 1.1.1.201 extracted from

  • Shiotsuki, H.; Maeda, Y.; Chijiiwa, K.
    Purification and characterization of 7beta-hydroxysteroid dehydrogenase from rabbit liver microsomes (2004), J. Steroid Biochem. Mol. Biol., 91, 185-190.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Oryctolagus cuniculus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
x * 34000, SDS-PAGE Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7beta-hydroxycholesterol + NADP+ Oryctolagus cuniculus
-
7-oxocholesterol + NADPH
-
?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme from liver microsomes 300fold by ion exchange, hydroxylapatite, 2',5'-ADP affinity Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.276
-
purified enzyme Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-cholesten-3beta,7beta-diol + NADP+ i.e. 7beta-hydroxycholesterol Oryctolagus cuniculus 5-cholesten-3beta-ol-7-one + NADPH
-
?
7beta-hydroxycholesterol + NADP+
-
Oryctolagus cuniculus 7-oxocholesterol + NADPH
-
?
corticosterone + NADP+ oxidation at C-11 Oryctolagus cuniculus 21-hydroxy-pregn-4-ene-3,11,20-trione + NADPH
-
?
cortisone + NADP+ oxidation at C-11 Oryctolagus cuniculus ? + NADPH
-
?
additional information enzyme might also show 11beta-hydroxysteroid dehydrogenase activity, no activity with cholesterol, 7alpha-hydroxycholesterol, 25-hydroxycholesterol, pregnenolone, dehydroepiandrosterone, chenodoxycolic acid, and ursodeoxycholic acid Oryctolagus cuniculus ?
-
?

Subunits

Subunits Comment Organism
? x * 34000, SDS-PAGE Oryctolagus cuniculus

Synonyms

Synonyms Comment Organism
7beta-HSD
-
Oryctolagus cuniculus
7beta-hydroxysteroid dehydrogenase
-
Oryctolagus cuniculus
More enzyme might belong to the rabbit type I 11beta-HSD enzyme family Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.7
-
potassium buffer Oryctolagus cuniculus
11
-
glycine-NaOH buffer Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
NADP+ beta-form is preferred Oryctolagus cuniculus