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Literature summary for 1.1.1.19 extracted from

  • Flynn, T.G.; Cromlish, J.A.; Davidson, W.S.
    Aldehyde reductase (L-hexonate: NADP dehydrogenase) from pig kidney (1982), Methods Enzymol., 89, 501-506.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,3-Butanedione
-
Sus scrofa
diethyldicarbonate
-
Sus scrofa
hydroxylamine
-
Sus scrofa
iodoacetic acid
-
Sus scrofa
NaF
-
Sus scrofa
p-chloromercuribenzoate
-
Sus scrofa
Phenobarbital
-
Sus scrofa
Phenylglyoxal
-
Sus scrofa
pyridoxal 5'-phosphate
-
Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.009
-
NADPH
-
Sus scrofa
0.02
-
NADP+ uncoupled reaction Sus scrofa
0.35
-
4-nitrobenzaldehyde
-
Sus scrofa
2.6
-
Pyridine-3-aldehyde
-
Sus scrofa
4.8
-
D-glyceraldehyde
-
Sus scrofa
7.3
-
L-gulonate
-
Sus scrofa
8.4
-
D-glucuronate
-
Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33000
-
SDS-PAGE, gel filtration Sus scrofa
36700
-
1 * 36700, SDS-PAGE Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.45
-
-
Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrobenzaldehyde + NADPH
-
Sus scrofa 4-nitrobenzyl alcohol + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Sus scrofa glycerol + NADP+
-
r
L-gulonate + NADP+
-
Sus scrofa D-glucuronate + NADPH
-
?
additional information broad specificity Sus scrofa ?
-
?
additional information reduction of D-glyceraldehyde: pro-4R hydrogen is transferred from NADPH, i.e. A-specific, attacks re face of carbonyl group of the D-glyceraldehyde Sus scrofa ?
-
?
pyridine-3-aldehyde + NADPH
-
Sus scrofa 3-hydroxypyridine + NADP+
-
r

Subunits

Subunits Comment Organism
monomer 1 * 36700, SDS-PAGE Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NADPH reduction of D-glyceraldehyde: pro-4R hydrogen is transferred from NADPH, i.e. A-specific, attacks re face of carbonyl group of the D-glyceraldehyde Sus scrofa