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Literature summary for 1.1.1.188 extracted from

  • Alzamil, H.A.; Pawade, J.; Fortier, M.A.; Bernal, A.L.
    Expression of the prostaglandin F synthase AKR1B1 and the prostaglandin transporter SLCO2A1 in human fetal membranes in relation to spontaneous term and preterm labor (2014), Front. Physiol., 5, 272.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
x * 37000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ Homo sapiens
-
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P15121
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fetal membrane
-
Homo sapiens
-
additional information in situ enzyme immunohistochemic analysis Homo sapiens
-
placenta
-
Homo sapiens
-
uterus the prostaglandin F synthase AKR1B1 is upregulated while prostaglandin transporter is downregulated during term labor. The amnion is more responsive than choriodecidua to stimulation with proinflammatory cytokines. The mechanisms of term and preterm labor are different, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
Homo sapiens (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+
-
?

Subunits

Subunits Comment Organism
? x * 37000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
AKR1B1
-
Homo sapiens
More cf. EC 1.1.1.21 Homo sapiens
PGF synthase
-
Homo sapiens
prostaglandin F synthase
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression of AKR1B1 is upregulated in the fetal membranes in association with term labor, during labor tumor necrosis factor TNF upregulates the AKR1B1 protein expression up

General Information

General Information Comment Organism
metabolism there are three different pathways for the synthesis of the uterotonic PGF2alpha: 1. from PGH2 by PGH 9-,11-endoperoxide reductase, 2. from PGD2 by PGD 11-ketoreductase, 3. from PGE2 by PGE 9-ketoreductase Homo sapiens