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Literature summary for 1.1.1.188 extracted from
- Coupling between cyclooxygenases and prostaglandin F(2alpha) synthase. Detection of an inducible, glutathione-activated, membrane-bound prostaglandin F2alpha-synthetic activity (2003), Biochim. Biophys. Acta, 1633, 96-105.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| GSH | - |
Homo sapiens |  |
| interleukin-1beta | membrane-associated, not soluble, isozyme in WI-38 cells | Homo sapiens | |
| lipopolysaccharide | induces the membrane-associated isozyme | Rattus norvegicus | |
| lipopolysaccharides | strong induction of the membrane-bound lung isozyme, slight induction in spleen, kidney, testis, and pancreas, overview | Mus musculus | |
| additional information | PGF synthase I activity in HEK 293 cells is unaffected by interleukin-1beta | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | coexpression of COX-1 and COX-2 increases the endogenous cytosolic PGFS-I activity, but only slightly the membrane-bound activity, overview | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| FeCl2 | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | not-inducible isozyme | Rattus norvegicus | 5829 | - |
| cytosol | not-inducible isozyme PGFS-I | Homo sapiens | 5829 | - |
| membrane | - |
Mus musculus | 16020 | - |
| membrane | inducible isozyme m-PGFS | Homo sapiens | 16020 | - |
| membrane | inducible isozyme m-PGFS | Rattus norvegicus | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | enzyme interacts with cyclooxygenase 1 and 2, isozyme PGFS-I interacts predominantly with cyclooxygenase 2, i.e. COX-2 | ? | - |
? | |
| additional information | Homo sapiens | the cytosolic enzyme synergistically interacts with cyclooxygenase 1 and 2, coupling, isozyme PGFS-I interacts predominantly with cyclooxygenase 2, i.e. COX-2 | ? | - |
? | |
| prostaglandin H2 + NADPH + H+ | Mus musculus | - |
prostaglandin F2alpha + NADP+ | - |
? | |
| prostaglandin H2 + NADPH + H+ | Homo sapiens | - |
prostaglandin F2alpha + NADP+ | - |
? | |
| prostaglandin H2 + NADPH + H+ | Rattus norvegicus | - |
prostaglandin F2alpha + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
2 isozymes PGFS-I and PGFS-II, soluble and membrane-associated isozymes | - |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
isozymes: 1 soluble not-inducible and 1 membraneous inducible by lipopolysaccharides | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| GOTO cell | glioblastoma cell | Homo sapiens | - |
| heart | - |
Mus musculus | - |
| HEK-293 cell | embryonic kidney cell, isozyme PGFS-I | Homo sapiens | - |
| HeLa cell | - |
Homo sapiens | - |
| intestine | - |
Mus musculus | - |
| kidney | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| lung | - |
Mus musculus | - |
| macrophage | peritoneal | Rattus norvegicus | - |
| pancreas | - |
Mus musculus | - |
| spleen | - |
Mus musculus | - |
| stomach | - |
Mus musculus | - |
| testis | - |
Mus musculus | - |
| thymus | - |
Mus musculus | - |
| U-251 cell | glioblastoma cell | Homo sapiens | - |
| WI-38 cell | lung fibroblast cell | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | enzyme interacts with cyclooxygenase 1 and 2, isozyme PGFS-I interacts predominantly with cyclooxygenase 2, i.e. COX-2 | Rattus norvegicus | ? | - |
? | |
| additional information | the cytosolic enzyme synergistically interacts with cyclooxygenase 1 and 2, coupling, isozyme PGFS-I interacts predominantly with cyclooxygenase 2, i.e. COX-2 | Homo sapiens | ? | - |
? | |
| prostaglandin H2 + NADPH + H+ | - |
Mus musculus | prostaglandin F2alpha + NADP+ | - |
? | |
| prostaglandin H2 + NADPH + H+ | - |
Homo sapiens | prostaglandin F2alpha + NADP+ | - |
? | |
| prostaglandin H2 + NADPH + H+ | - |
Rattus norvegicus | prostaglandin F2alpha + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| m-PGFS | - |
Mus musculus |
| m-PGFS | - |
Rattus norvegicus |
| PGF synthase | - |
Homo sapiens |
| PGF2alpha-synthetic activity | - |
Rattus norvegicus |
| PGFS | - |
Rattus norvegicus |
| prostaglandin F2alpha synthase | - |
Mus musculus |
| prostaglandin F2alpha synthase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 24 | - |
assay at | Homo sapiens |
| 24 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Homo sapiens |
| 8 | - |
assay at | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Mus musculus | |
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Rattus norvegicus | |
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