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Literature summary for 1.1.1.149 extracted from

  • Stefane, B.; Brozic, P.; Vehovc, M.; Rizner, T.L.; Gobec, S.
    New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3 (2009), Eur. J. Med. Chem., 44, 2563-2571.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-phenylcyclopentanecarboxylic acid
-
Homo sapiens
2-(4-chlorobenzylidene)cyclopentanone
-
Homo sapiens
2-(4-chlorobenzylidene)cyclopentyl ethyl ether
-
Homo sapiens
3-phenylcyclopentanecarboxylic acid
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q04828
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3
-
pH 6.5, temperature not specified in the publication Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-acenaphthenol + NAD+
-
Homo sapiens ? + NADH + H+
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0172
-
2-(4-chlorobenzylidene)cyclopentanone pH 6.5, temperature not specified in the publication Homo sapiens
0.0305
-
2-(4-chlorobenzylidene)cyclopentyl ethyl ether pH 6.5, temperature not specified in the publication Homo sapiens
0.0358
-
1-phenylcyclopentanecarboxylic acid pH 6.5, temperature not specified in the publication Homo sapiens
0.0485
-
3-phenylcyclopentanecarboxylic acid pH 6.5, temperature not specified in the publication Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.035
-
pH 6.5, temperature not specified in the publication Homo sapiens 2-(4-chlorobenzylidene)cyclopentanone
0.0621
-
pH 6.5, temperature not specified in the publication Homo sapiens 2-(4-chlorobenzylidene)cyclopentyl ethyl ether
0.0729
-
pH 6.5, temperature not specified in the publication Homo sapiens 1-phenylcyclopentanecarboxylic acid
0.0986
-
pH 6.5, temperature not specified in the publication Homo sapiens 3-phenylcyclopentanecarboxylic acid