Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | human chorionic gonadotropin induces expression of AKR1C23 | Equus caballus |
Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis, expression analysis of AKR1C23 in preovulatory follicles, overexpression in HEK-293 cells | Equus caballus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.003 | 0.012 | 17alpha-hydroxyprogesterone | - |
Equus caballus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
17alpha-hydroxyprogesterone + NAD(P)H | Equus caballus | the aldo-keto reductase, AKR1C23, also shows 20alpha-hydroxysteroid dehydrogenase activity in vivo, enzyme regulation in preovulatory follicles and corpora lutea, overview | 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Equus caballus | Q1XAA8 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | very low expression rate of AKR1C23 | Equus caballus | - |
brain | low expression rate of AKR1C23 | Equus caballus | - |
granulosa cell | - |
Equus caballus | - |
heart | moderate expression rate of AKR1C23 | Equus caballus | - |
kidney | moderate expression rate of AKR1C23 | Equus caballus | - |
liver | moderate expression rate of AKR1C23 | Equus caballus | - |
lung | moderate expression rate of AKR1C23 | Equus caballus | - |
ovarian follicle | preovulatory, very high expression rate, expression analysis of AKR1C23, activity during follicular luteinization, overview | Equus caballus | - |
skeletal muscle | moderate expression rate of AKR1C23 | Equus caballus | - |
skin | very low expression rate of AKR1C23 | Equus caballus | - |
spleen | very low expression rate of AKR1C23 | Equus caballus | - |
stomach | low expression rate of AKR1C23 | Equus caballus | - |
testis | very high expression rate of AKR1C23 | Equus caballus | - |
thymus | very low expression rate of AKR1C23 | Equus caballus | - |
uterus | low expression rate of AKR1C23 | Equus caballus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17alpha-hydroxyprogesterone + NAD(P)H | - |
Equus caballus | 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ | - |
r | |
17alpha-hydroxyprogesterone + NAD(P)H | the aldo-keto reductase, AKR1C23, also shows 20alpha-hydroxysteroid dehydrogenase activity in vivo, enzyme regulation in preovulatory follicles and corpora lutea, overview | Equus caballus | 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
AKR1C23 | - |
Equus caballus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD(P)+ | - |
Equus caballus | |
NAD(P)H | - |
Equus caballus |