Cloned (Comment) | Organism |
---|---|
cDNA of skin fibroblast cDNA library inserted into pCMV expression vector, transiently transfected into and expressed in HEK-293 cells | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | rapid activity decrease upon homogenization | Homo sapiens | |
0.0006 | - |
progesterone | NADPH, intact cells | Homo sapiens | |
0.0066 | - |
progesterone | NADPH, cell homogenate | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
48150 | - |
estimated by 1.3 kb cDNA | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
progesterone + NADPH | Homo sapiens | - |
20alpha-hydroxyprogesterone + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mammalia | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ = 17alpha-hydroxyprogesterone + NAD(P)H + H+ | aldoketo reductase superfamily | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | 20alpha-HSD mRNA very low expressed | Homo sapiens | - |
brain | 20alpha-HSD mRNA highly expressed | Homo sapiens | - |
gland | 20alpha-HSD mRNA highly expressed | Mammalia | - |
HaCaT cell | - |
Homo sapiens | - |
liver | 20alpha-HSD mRNA highly expressed | Homo sapiens | - |
prostate gland | 20alpha-HSD mRNA lower expressed | Homo sapiens | - |
skin | fibroblast | Homo sapiens | - |
testis | 20alpha-HSD mRNA lower expressed | Homo sapiens | - |
uterus | 20alpha-HSD mRNA lower expressed | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | negligible activity with dehydroepiandrosterone, estrone estradiol, 4-androstenendione, testosterone and diydrotestosterone as substrates | Homo sapiens | ? | - |
? | |
progesterone + NAD(P)H | NADPH much more efficient, 4-fold lower Km | Homo sapiens | 20alpha-hydroxyprogesterone + NAD(P)+ | - |
? | |
progesterone + NADPH | - |
Homo sapiens | 20alpha-hydroxyprogesterone + NADP+ | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |