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Literature summary for 1.1.1.148 extracted from

  • Johnston, J.; Renwick, A.G.C.
    Oestradiol-17alpha dehydrogenase from chicken liver (1984), Biochem. J., 222, 761-768.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.148

Inhibitors

Inhibitors Comment Organism Structure
17beta-(1-Oxoprop-2-ynyl)androst-4-ene-3-one
-
 Gallus gallus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0087 0.011 NADP+
-
 Gallus gallus
0.017 0.025 17alpha-estradiol
-
 Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
2 forms Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Gallus gallus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.2
-
-
 Gallus gallus

Storage Stability

Storage Stability Organism
-20°C, 50% v/v glycerol Gallus gallus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17alpha-estradiol + NAD(P)+
-
 Gallus gallus estrone + NAD(P)H
-
 ?
17alpha-hydroxy-4-androsten-3-one + NADP+ epitestosterone Gallus gallus 4-androsten-3,17-dione + NADPH
-
 r
17beta-hydroxy-4-androsten-3-one + NADP+ testosterone Gallus gallus 4-androsten-3,17-dione + NADPH
-
 ?
5alpha-androstan-3beta,17alpha-diol + NADP+
-
 Gallus gallus 3beta-hydroxy-5alpha-androstan-17-one + NADPH
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9 9.5
-
 Gallus gallus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Gallus gallus
NADP+
-
 Gallus gallus