Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2S)-2-[[(E)-[(1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]-3-(4-hydroxyphenyl)propanoic acid | - |
Rattus norvegicus | |
(E)-5-((benzo[d]thiazol-2-ylimino)(methylthio)methylamino)-2-hydroxybenzoic acid | - |
Rattus norvegicus | |
2-hydroxy-5-[[(E)-[(5-methoxy-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]benzoic acid | - |
Rattus norvegicus | |
2-hydroxy-5-[[(E)-[(5-methyl-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]benzoic acid | - |
Rattus norvegicus | |
2-hydroxy-5-[[(E)-[(6-methoxy-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]benzoic acid | - |
Rattus norvegicus | |
2-hydroxy-5-[[(E)-[(6-methyl-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]benzoic acid | - |
Rattus norvegicus | |
2-hydroxy-5-[[(E)-[(7-methoxy-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]benzoic acid | - |
Rattus norvegicus | |
2-hydroxy-5-[[(E)-[(7-methyl-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]benzoic acid | - |
Rattus norvegicus | |
5-[[(E)-[(5-chloro-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]-2-hydroxybenzoic acid | - |
Rattus norvegicus | |
5-[[(E)-[(5-ethoxy-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]-2-hydroxybenzoic acid | - |
Rattus norvegicus | |
5-[[(E)-[(5-fluoro-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]-2-hydroxybenzoic acid | - |
Rattus norvegicus | |
5-[[(E)-[(6-chloro-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]-2-hydroxybenzoic acid | - |
Rattus norvegicus | |
5-[[(E)-[(6-ethoxy-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]-2-hydroxybenzoic acid | - |
Rattus norvegicus | |
5-[[(E)-[(6-fluoro-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]-2-hydroxybenzoic acid | - |
Rattus norvegicus | |
5-[[(E)-[(7-chloro-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]-2-hydroxybenzoic acid | - |
Rattus norvegicus | |
5-[[(E)-[(7-ethoxy-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]-2-hydroxybenzoic acid | - |
Rattus norvegicus | |
5-[[(E)-[(7-fluoro-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]-2-hydroxybenzoic acid | - |
Rattus norvegicus | |
carbenoxolone | - |
Rattus norvegicus | |
clobenzorex | - |
Rattus norvegicus | |
PF-877423 | - |
Rattus norvegicus | |
resveratrol | - |
Rattus norvegicus | |
SAR184841 | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.193 | - |
cortisone | at pH 7.5 and 37°C | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
corticosterone + NADPH + H+ | Rattus norvegicus | - |
corticosterol + NADP+ | - |
? | |
cortisone + NADPH + H+ | Rattus norvegicus | - |
cortisol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P16232 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
white adipose tissue | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
corticosterone + NADPH + H+ | - |
Rattus norvegicus | corticosterol + NADP+ | - |
? | |
cortisone + NADPH + H+ | - |
Rattus norvegicus | cortisol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11-beta hydroxysteroid dehydrogenase type 1 | - |
Rattus norvegicus |
11beta-HSD1 | - |
Rattus norvegicus |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | the inhibition of isoform 11beta-HSD1 attenuates the development of type 2 diabetes mellitus, insulin resistance, metabolic syndrome and other diseases mediated by excessive cortisol production | Rattus norvegicus |