Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2-benzyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-3-yl)(phenyl)methanone | - |
Homo sapiens | |
(4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-3-yl)(phenyl)methanone | - |
Homo sapiens | |
(4-hydroxy-2-methyl-1,1-dioxido-2H-1,2-benzothiazin-3-yl)(phenyl)methanone | - |
Homo sapiens | |
2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)-1-(4-nitrophenyl)ethanone | - |
Homo sapiens | |
2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)-1-(biphenyl-4-yl)ethanone | - |
Homo sapiens | |
2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)-1-phenylethanone | - |
Homo sapiens | |
2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)-1-phenylethanone | - |
Mus musculus | |
2-[(3-benzoyl-2-methyl-1,1-dioxido-2H-1,2-benzothiazin-4-yl)oxy]-1-phenylethanone | - |
Homo sapiens | |
3-benzoyl-1,1-dioxido-2-(2-oxo-2-phenylethyl)-2H-1,2-benzothiazin-4-yl trifluoromethanesulfonate | - |
Homo sapiens | |
4-[(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)acetyl]benzoic acid | - |
Homo sapiens | |
4-[(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)acetyl]benzonitrile | - |
Homo sapiens | |
4-[(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)acetyl]benzonitrile | - |
Mus musculus | |
carbenoxolone | - |
Homo sapiens | |
ethyl 4-hydroxy-2-(2-oxo-2-phenylethyl)-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide | - |
Homo sapiens | |
ethyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide | - |
Homo sapiens | |
methyl 4-[(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)acetyl]benzoate | - |
Homo sapiens | |
[4-hydroxy-1,1-dioxido-2-(2-phenylethyl)-2H-1,2-benzothiazin-3-yl](phenyl)methanone | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Mus musculus | 5783 | - |
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | - |
Mus musculus | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-hydroxysteroid dehydrogenase 1 | - |
Mus musculus |
11beta-hydroxysteroid dehydrogenase 1 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000028 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)-1-(biphenyl-4-yl)ethanone | |
0.00003 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)-1-(4-nitrophenyl)ethanone | |
0.000031 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)-1-phenylethanone | |
0.000031 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | methyl 4-[(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)acetyl]benzoate | |
0.00004 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4-[(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)acetyl]benzonitrile | |
0.000234 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [4-hydroxy-1,1-dioxido-2-(2-phenylethyl)-2H-1,2-benzothiazin-3-yl](phenyl)methanone | |
0.000254 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (2-benzyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-3-yl)(phenyl)methanone | |
0.000388 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (4-hydroxy-2-methyl-1,1-dioxido-2H-1,2-benzothiazin-3-yl)(phenyl)methanone | |
0.0005 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | carbenoxolone | |
0.000547 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[(3-benzoyl-2-methyl-1,1-dioxido-2H-1,2-benzothiazin-4-yl)oxy]-1-phenylethanone | |
0.00072 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4-[(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)acetyl]benzoic acid | |
0.00074 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 3-benzoyl-1,1-dioxido-2-(2-oxo-2-phenylethyl)-2H-1,2-benzothiazin-4-yl trifluoromethanesulfonate | |
0.003 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | ethyl 4-hydroxy-2-(2-oxo-2-phenylethyl)-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide | |
0.0045 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | ethyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide | |
0.0078 | - |
pH not specified in the publication, temperature not specified in the publication | Mus musculus | 2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)-1-phenylethanone | |
0.009 | - |
pH not specified in the publication, temperature not specified in the publication | Mus musculus | 4-[(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)acetyl]benzonitrile | |
0.0148 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-3-yl)(phenyl)methanone |