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Literature summary for 1.1.1.146 extracted from

  • Su, X.; Vicker, N.; Trusselle, M.; Halem, H.; Culler, M.D.; Potter, B.V.
    Discovery of novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1 (2009), Mol. Cell. Endocrinol., 301, 169-173.
    View publication on PubMed
Search for more literature for 1.1.1.146

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2,5-dichloro-N-(2-methyl-1,3-benzothiazol-5-yl)benzenesulfonamide
-
 Homo sapiens
2-(adamantan-1-yl)-N-methyl-N-(thiophen-3-ylmethyl)acetamide
-
 Homo sapiens
2-adamantan-1-yl-N-methyl-N-thiophen-2-ylmethyl-acetamide
-
 Homo sapiens
3,5-dichloro-N-(2-methyl-1,3-benzothiazol-5-yl)benzamide
-
 Homo sapiens
5-(adamantan-1-ylcarbonyl)-4H,5H,6H,7H-thieno[3,2-c]pyridine
-
 Homo sapiens
N-(4-chloro-2-methyl-1,3-benzothiazol-5-yl)adamantane-1-carboxamide
-
 Homo sapiens
N-(furan-2-ylmethyl)-N-methyladamantane-1-carboxamide
-
 Homo sapiens
N-(thiophen-2-ylmethyl)adamantane-1-carboxamide
-
 Homo sapiens
N-methyl-N-(thiophen-2-ylmethyl)adamantane-1-carboxamide
-
 Homo sapiens
N-methyl-N-(thiophen-3-ylmethyl)adamantane-1-carboxamide
-
 Homo sapiens
N-methyl-N-[(1-methyl-1H-pyrrol-2-yl)methyl]adamantane-1-carboxamide
-
 Homo sapiens
N-methyl-N-[2-(thiophen-2-yl)ethyl]adamantane-1-carboxamide
-
 Homo sapiens
N-[(1-methyl-1H-pyrrol-2-yl)methyl]adamantane-1-carboxamide
-
 Homo sapiens
N-[2-(thiophen-2-yl)ethyl]adamantane-1-carboxamide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisol + NADP+
-
 Homo sapiens cortisone + NADPH
-
 r

Synonyms

Synonyms Comment Organism
11beta-HSD1
-
 Homo sapiens
11beta-hydroxysteroid dehydrogenase type 1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000113
-
-
 Homo sapiens N-methyl-N-[(1-methyl-1H-pyrrol-2-yl)methyl]adamantane-1-carboxamide
0.000125
-
-
 Homo sapiens N-methyl-N-(thiophen-3-ylmethyl)adamantane-1-carboxamide
0.000229
-
-
 Homo sapiens N-methyl-N-(thiophen-2-ylmethyl)adamantane-1-carboxamide
0.000249
-
-
 Homo sapiens N-(furan-2-ylmethyl)-N-methyladamantane-1-carboxamide
0.000308
-
-
 Homo sapiens 2-adamantan-1-yl-N-methyl-N-thiophen-2-ylmethyl-acetamide
0.00035
-
-
 Homo sapiens 2-(adamantan-1-yl)-N-methyl-N-(thiophen-3-ylmethyl)acetamide
0.000403
-
-
 Homo sapiens N-(thiophen-2-ylmethyl)adamantane-1-carboxamide
0.000435
-
-
 Homo sapiens 5-(adamantan-1-ylcarbonyl)-4H,5H,6H,7H-thieno[3,2-c]pyridine
0.000448
-
-
 Homo sapiens N-methyl-N-[2-(thiophen-2-yl)ethyl]adamantane-1-carboxamide
0.000679
-
-
 Homo sapiens N-[2-(thiophen-2-yl)ethyl]adamantane-1-carboxamide
0.0017
-
-
 Homo sapiens N-[(1-methyl-1H-pyrrol-2-yl)methyl]adamantane-1-carboxamide
0.0032
-
 at 37°C Homo sapiens 3,5-dichloro-N-(2-methyl-1,3-benzothiazol-5-yl)benzamide
0.0032
-
 at 37°C Homo sapiens 2,5-dichloro-N-(2-methyl-1,3-benzothiazol-5-yl)benzenesulfonamide
0.00528
-
-
 Homo sapiens N-(4-chloro-2-methyl-1,3-benzothiazol-5-yl)adamantane-1-carboxamide