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Literature summary for 1.1.1.146 extracted from

  • Classen-Houben, D.; Schuster, D.; Da Cunha, T.; Odermatt, A.; Wolber, G.; Jordis, U.; Kueenburg, B.
    Selective inhibition of 11beta-hydroxysteroid dehydrogenase 1 by 18alpha-glycyrrhetinic acid but not 18beta-glycyrrhetinic acid (2009), J. Steroid Biochem. Mol. Biol., 113, 248-252.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
18alpha-glycyrrhetinic acid selective inhibition of 11beta-HSD1, does not inhibit 11beta-HSD2 at concentrations up to 0.02 mM Homo sapiens
18beta-glycyrrhetinic acid inhibits both 11beta-HSD1 and 11beta-HSD2, but preferentially inhibits 11beta-HSD2 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisol + NADP+ Homo sapiens
-
cortisone + NADPH
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens P28845
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisol + NADP+
-
Homo sapiens cortisone + NADPH
-
r

Synonyms

Synonyms Comment Organism
11beta-HSD1
-
Homo sapiens
11beta-hydroxysteroid dehydrogenase 1
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000779
-
37°C, pH not specified in the publication Homo sapiens 18beta-glycyrrhetinic acid
0.002214
-
37°C, pH not specified in the publication Homo sapiens 18alpha-glycyrrhetinic acid