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Literature summary for 1.1.1.146 extracted from

  • Balachandran, A.; Guan, H.; Sellan, M.; van Uum, S.; Yang, K.
    Insulin and dexamethasone dynamically regulate adipocyte 11beta-hydroxysteroid dehydrogenase type 1 (2008), Endocrinology, 149, 4069-4079.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Insulin insulin stimulates 11beta-HSD1 activity and expression in a time- and concentration-dependent manner, the p38 MAPK inhibitor SB-220025, but not the ERK inhibitor U-0126 or the phosphatidylinositol 3-kinase inhibitor LY294002, prevent insulin stimulation of 11beta-HSD1 activity Mus musculus
Insulin insulin stimulates 11beta-HSD1 activity and expression in a time- and concentration-dependent manner, the p38 MAPK inhibitor SB-220025, but not the ERK inhibitor U-0126 or the phosphatidylinositol 3-kinase inhibitor LY294002, prevent insulin stimulation of 11beta-HSD1 activity Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
dexamethasone dexmethasone inhibits 11beta-HSD1 activity and expression in a time- and concentration-dependent manner, the effect of dexamethasone is mimicked by both cortisol and corticosterone but blocked by the glucocorticoid receptor antagonist RU486 Mus musculus
dexamethasone dexmethasone inhibits 11beta-HSD1 activity and expression in a time- and concentration-dependent manner, the effect of dexamethasone is mimicked by both cortisol and corticosterone but blocked by the glucocorticoid receptor antagonist RU486 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
-
Mus musculus
-
adipocyte
-
Mus musculus
-
white adipose tissue
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-dehydrocorticosterone + NADPH
-
Mus musculus corticosterone + NADP+
-
?
11-dehydrocorticosterone + NADPH
-
Rattus norvegicus corticosterone + NADP+
-
?
cortisone + NADPH + H+
-
Mus musculus cortisol + NADP+
-
?
cortisone + NADPH + H+
-
Rattus norvegicus cortisol + NADP+
-
?

Synonyms

Synonyms Comment Organism
11beta-HSD1
-
Mus musculus
11beta-HSD1
-
Rattus norvegicus
11beta-hydroxysteroid dehydrogenase type 1
-
Mus musculus
11beta-hydroxysteroid dehydrogenase type 1
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Mus musculus
NADPH
-
Rattus norvegicus