KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000237 | - |
cortisol | enzyme from caput epididymidis, cosubstrate NADP+, 37°C, pH not specified in the publication | Sus scrofa | |
0.000254 | - |
cortisol | enzyme from testis, cosubstrate NADP+, 37°C, pH not specified in the publication | Sus scrofa | |
0.000433 | - |
cortisol | enzyme from bulbourethral gland, cosubstrate NADP+, 37°C, pH not specified in the publication | Sus scrofa |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32000 | - |
x * 32000, isoform 11betaHSD1, SDS-PAGE | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Sus scrofa | physiological role of 11beta-hydroxysteroid dehydrogenase in limiting any local actions of glucocorticoids within the reproductive tissues | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bulbourethral gland | pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+ | Sus scrofa | - |
caput epididymis | pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+ | Sus scrofa | - |
cauda epididymis | presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands | Sus scrofa | - |
corpus epididymis | presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands | Sus scrofa | - |
prostate gland | presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands | Sus scrofa | - |
testis | pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+ | Sus scrofa | - |
vas deferens | presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands | Sus scrofa | - |
vesicular gland | presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands | Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisol + NADP+ | - |
Sus scrofa | cortisone + NADPH | - |
r | |
additional information | physiological role of 11beta-hydroxysteroid dehydrogenase in limiting any local actions of glucocorticoids within the reproductive tissues | Sus scrofa | ? | - |
? | |
additional information | maximal rates for NADP+-dependent cortisol oxidation are 7.4-28.5fold greater than the Vmax for NADPH-dependent reduction of cortisone, and are comparable with the rates of NAD+-dependent cortisol metabolism | Sus scrofa | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 32000, isoform 11betaHSD1, SDS-PAGE | Sus scrofa |
Synonyms | Comment | Organism |
---|---|---|
11betaHSD1 | - |
Sus scrofa |
NADP(+)-dependent 11beta-dehydrogenase | - |
Sus scrofa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Sus scrofa |