Application | Comment | Organism |
---|---|---|
analysis | high-throughput screening for potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I | Mus musculus |
analysis | high-throughput screening for potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[(2,4-dichlorophenyl)sulfonyl]-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine | - |
Homo sapiens | |
1-[(2-naphthylphenyl)sulfonyl]-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine | - |
Homo sapiens | |
1-[(4-methylphenyl)sulfonyl]-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine | - |
Homo sapiens | |
1-[(4-nitrophenyl)sulfonyl]-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine | - |
Homo sapiens | |
1-[(4-tert-butylphenyl)sulfonyl]-(2R)-2-methyl-4-(4-nitrophenyl)piperazine | - |
Homo sapiens | |
1-[(4-tert-butylphenyl)sulfonyl]-(2R)-2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine | - |
Homo sapiens | |
1-[(4-tert-butylphenyl)sulfonyl]-(2S)-2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine | - |
Homo sapiens | |
1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine | - |
Homo sapiens | |
1-[(4-tert-butylphenyl)sulfonyl]-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine | - |
Homo sapiens | |
1-[(4-tert-butylphenyl)sulfonyl]-5-[3-(trifluoromethyl)pyridin-2-yl]-1,5-diazocane | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
11 beta-hydroxysteroid dehydrogenase type 1 | - |
Mus musculus | - |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-dehydrocortisone + NADPH | - |
Mus musculus | 1,2-dehydrocortisol + NADP+ | - |
? | |
1,2-dehydrocortisone + NADPH | - |
Homo sapiens | 1,2-dehydrocortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000003 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(4-tert-butylphenyl)sulfonyl]-5-[3-(trifluoromethyl)pyridin-2-yl]-1,5-diazocane | |
0.000003 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(4-tert-butylphenyl)sulfonyl]-(2R)-2-methyl-4-(4-nitrophenyl)piperazine | |
0.000004 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(4-tert-butylphenyl)sulfonyl]-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine | |
0.000007 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dichlorophenyl)sulfonyl]-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine | |
0.000009 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine | |
0.000009 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(4-tert-butylphenyl)sulfonyl]-(2S)-2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine | |
0.00001 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(4-nitrophenyl)sulfonyl]-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine | |
0.000011 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(4-tert-butylphenyl)sulfonyl]-(2R)-2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine | |
0.000013 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2-naphthylphenyl)sulfonyl]-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine | |
0.000016 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(4-methylphenyl)sulfonyl]-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine |