Application | Comment | Organism |
---|---|---|
analysis | use of microdialysis sampling coupled with liquid chromatography/electrospray ionization mass spectrometry to study 11beta-hydroxysteroid dehydrogenase type 1 catalyzed conversion of stable-isotope-labeled cortisone to cortisol in liver microsome. Results show species-specific reaction profiles, with a five times higher coversion rate in dog than in human and monkey liver microsome | Homo sapiens |
analysis | use of microdialysis sampling coupled with liquid chromatography/electrospray ionization mass spectrometry to study 11beta-hydroxysteroid dehydrogenase type 1 catalyzed conversion of stable-isotope-labeled cortisone to cortisol in liver microsome. Results show species-specific reaction profiles, with a five times higher coversion rate in dog than in human and monkey liver microsome | Canis lupus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Canis lupus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus | - |
- |
- |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | species-specific reaction profiles of 11beta-hydroxysteroid dehydrogenase, with a five times higher conversion rate in dog than in human and monkey liver microsome | Homo sapiens | - |
liver | species-specific reaction profiles of 11beta-hydroxysteroid dehydrogenase, with a five times higher conversion rate in dog than in human and monkey liver microsome | Canis lupus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | - |
Canis lupus | cortisol + NADP+ | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADP+ | - |
Canis lupus | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Canis lupus |