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Literature summary for 1.1.1.146 extracted from

  • Maser, E.; Friebertshauser, J.; Volker, B.
    Purification, characterization and NNK carbonyl reductase activities of 11beta-hydroxysteroid dehydrogenase type 1 from human liver: enzyme cooperativity and significance in the detoxification of a tobacco-derived carcinogen (2003), Chem. Biol. Interact., 143-144, 435-448.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
glycyrrhetinic acid
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.041
-
cortisol
-
Homo sapiens
0.043
-
corticosterone
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Homo sapiens 5783
-
membrane membrane bound Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
2 * 34000, SDS-PAGE Homo sapiens
67400
-
gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisone + NADPH + H+ Homo sapiens bidirectional reaction in vitro, it is suggested that in vivo 11beta-HSD 1 functions primarly as reductase, reactivating inert 11-oxo glucocorticoids to the corresponding receptor-active 11beta-hydroxy forms cortisol + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Octyl-Sepharose, Mono Q-Sepharose, Red-Sepharose Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-dehydrocorticosterone + NADPH + H+
-
Homo sapiens corticosterone + NADP+
-
r
4-methylnitrosamine-1-(3-pyridiyl)-1-butanone + NADPH
-
Homo sapiens 4-methylnitrosamine-1-(3-pyridiyl)-1-butanol + NADP+
-
?
corticosterone + NADPH + H+
-
Homo sapiens corticosterol + NADP+
-
r
cortisone + NADPH + H+ bidirectional reaction in vitro, it is suggested that in vivo 11beta-HSD 1 functions primarly as reductase, reactivating inert 11-oxo glucocorticoids to the corresponding receptor-active 11beta-hydroxy forms Homo sapiens cortisol + NADP+
-
r

Subunits

Subunits Comment Organism
dimer 2 * 34000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
11beta-hydroxysteroid dehydrogenase type 1
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000005
-
glycyrrhetinic acid vs. cortisol Homo sapiens
0.00001
-
glycyrrhetinic acid vs. 4-methylnitrosamine-1-(3-pyridiyl)-1-butanone Homo sapiens
0.000014
-
glycyrrhetinic acid vs. cortisone Homo sapiens