Inhibitors | Comment | Organism | Structure |
---|---|---|---|
glycyrrhetinic acid | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.041 | - |
cortisol | - |
Homo sapiens | |
0.043 | - |
corticosterone | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
membrane | membrane bound | Homo sapiens | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
34000 | - |
2 * 34000, SDS-PAGE | Homo sapiens |
67400 | - |
gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | Homo sapiens | bidirectional reaction in vitro, it is suggested that in vivo 11beta-HSD 1 functions primarly as reductase, reactivating inert 11-oxo glucocorticoids to the corresponding receptor-active 11beta-hydroxy forms | cortisol + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Octyl-Sepharose, Mono Q-Sepharose, Red-Sepharose | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-dehydrocorticosterone + NADPH + H+ | - |
Homo sapiens | corticosterone + NADP+ | - |
r | |
4-methylnitrosamine-1-(3-pyridiyl)-1-butanone + NADPH | - |
Homo sapiens | 4-methylnitrosamine-1-(3-pyridiyl)-1-butanol + NADP+ | - |
? | |
corticosterone + NADPH + H+ | - |
Homo sapiens | corticosterol + NADP+ | - |
r | |
cortisone + NADPH + H+ | bidirectional reaction in vitro, it is suggested that in vivo 11beta-HSD 1 functions primarly as reductase, reactivating inert 11-oxo glucocorticoids to the corresponding receptor-active 11beta-hydroxy forms | Homo sapiens | cortisol + NADP+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 34000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000005 | - |
glycyrrhetinic acid | vs. cortisol | Homo sapiens | |
0.00001 | - |
glycyrrhetinic acid | vs. 4-methylnitrosamine-1-(3-pyridiyl)-1-butanone | Homo sapiens | |
0.000014 | - |
glycyrrhetinic acid | vs. cortisone | Homo sapiens |