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Literature summary for 1.1.1.145 extracted from

  • Chen, G.; Bai, Y.; Ren, L.; Zhu, D.; Li, Y.; Fang, M.; Al-Kateb, H.; Doran, O.
    Metabolism of androstenone, 17beta-estradiol and dihydrotestosterone in primary cultured pig hepatocytes and the role of 3beta-hydroxysteroid dehydrogenase in this process (2015), PLoS ONE, 10, e113194.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
trilostane specific inhibitor Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
androstenone + NAD+ Sus scrofa
-
5alpha-androst-16-en-3beta-ol + NADH + H+
-
?
pregnenolone + NAD+ Sus scrofa
-
pregn-5-en-3,20-dione + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
androstenone + NAD+
-
Sus scrofa 5alpha-androst-16-en-3beta-ol + NADH + H+
-
?
pregnenolone + NAD+
-
Sus scrofa pregn-5-en-3,20-dione + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
3-beta-hydroxysteroid dehydrogenase
-
Sus scrofa
3betaHSD
-
Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Sus scrofa

General Information

General Information Comment Organism
metabolism isoform 3bHSD2 interacts with the mitochondrial translocase, Tim50, to regulate progesterone and androstenedione formation Sus scrofa