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Literature summary for 1.1.1.145 extracted from

  • Thomas, J.L.; Huether, R.; Mack, V.L.; Scaccia, L.A.; Stoner, R.C.; Duax, W.L.
    Structure/function of human type 1 3beta-hydroxysteroid dehydrogenase: An intrasubunit disulfide bond in the Rossmann-fold domain and a Cys residue in the active site are critical for substrate and coenzyme utilization (2007), J. Steroid Biochem. Mol. Biol., 107, 80-87.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
C111A contrary to wild-type, presence of 2-mercaptoethanol does not decrease Km value for substrate and NAD+ Homo sapiens
C111S contrary to wild-type, presence of 2-mercaptoethanol does not decrease Km value for substrate and NAD+ Homo sapiens
C72F contrary to wild-type, presence of 2-mercaptoethanol does not decrease Km value for substrate and NAD+ Homo sapiens
C72S contrary to wild-type, presence of 2-mercaptoethanol does not decrease Km value for substrate and NAD+ Homo sapiens
C83A 2-5fold increase in Km values Homo sapiens
C83S no catalytic acitivity Homo sapiens
C83S similar to wild-type, presence of 2-mercaptoethanol results in 2.5fold decrease of Km values Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0007
-
dehydroepiandrosterone wild-type, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.0028
-
dehydroepiandrosterone mutant C72S, pH 7.4 Homo sapiens
0.0037
-
dehydroepiandrosterone wild-type, pH 7.4 Homo sapiens
0.0044
-
dehydroepiandrosterone mutant C72S, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.0075
-
dehydroepiandrosterone mutant C83A, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.0115
-
dehydroepiandrosterone mutant C72F, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.012
-
NAD+ wild-type, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.0127
-
dehydroepiandrosterone mutant C72F, pH 7.4 Homo sapiens
0.0153
-
NAD+ mutant C72S, pH 7.4 Homo sapiens
0.0166
-
NAD+ mutant C111S, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.0168
-
dehydroepiandrosterone mutant C111S, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.0171
-
dehydroepiandrosterone mutant C83A, pH 7.4 Homo sapiens
0.0181
-
dehydroepiandrosterone mutant C111S, pH 7.4 Homo sapiens
0.019
-
NAD+ mutant C111S, pH 7.4 Homo sapiens
0.0194
-
NAD+ mutant C72S, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.0227
-
NAD+ mutant C111A, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.0237
-
dehydroepiandrosterone mutant C111A, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.0255
-
NAD+ mutant C111A, pH 7.4 Homo sapiens
0.0268
-
dehydroepiandrosterone mutant C111A, pH 7.4 Homo sapiens
0.0299
-
NAD+ mutant C83A, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.0341
-
NAD+ wild-type, pH 7.4 Homo sapiens
0.0468
-
NAD+ mutant C72F, pH 7.4 Homo sapiens
0.0476
-
NAD+ mutant C72F, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.0732
-
NAD+ mutant C83A, pH 7.4 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
type 1 enzyme
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dehydroepiandrosterone + NAD+
-
Homo sapiens androst-5-en-3,17-dione + NADH + H+
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.02
-
dehydroepiandrosterone wild-type, pH 7.4 Homo sapiens
0.02
-
NAD+ wild-type, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.021
-
dehydroepiandrosterone wild-type, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.022
-
NAD+ wild-type, pH 7.4 Homo sapiens
0.03
-
dehydroepiandrosterone mutant C111S, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.031
-
NAD+ mutant C111S, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.032
-
dehydroepiandrosterone mutant C111S, pH 7.4 Homo sapiens
0.033
-
NAD+ mutant C111S, pH 7.4 Homo sapiens
0.04
-
NAD+ mutant C111A, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.043
-
NAD+ mutant C72S, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.047
-
dehydroepiandrosterone mutant C111A, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.047
-
NAD+ mutant C72S, pH 7.4 Homo sapiens
0.048
-
NAD+ mutant C83A, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.048
-
dehydroepiandrosterone mutant C83A, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.05
-
dehydroepiandrosterone mutant C72S, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.053
-
dehydroepiandrosterone mutant C72S, pH 7.4 Homo sapiens
0.055
-
dehydroepiandrosterone mutant C83A, pH 7.4 Homo sapiens
0.057
-
NAD+ mutant C83A, pH 7.4 Homo sapiens
0.06
-
dehydroepiandrosterone mutant C111A, pH 7.4 Homo sapiens
0.063
-
NAD+ mutant C111A, pH 7.4 Homo sapiens
0.087
-
NAD+ mutant C72F, pH 7.4 Homo sapiens
0.087
-
dehydroepiandrosterone mutant C72F, pH 7.4 Homo sapiens
0.087
-
NAD+ mutant C72F, presence of 2-mercatoethanol pH 7.4 Homo sapiens
0.087
-
dehydroepiandrosterone mutant C72F, presence of 2-mercatoethanol pH 7.4 Homo sapiens