Protein Variants | Comment | Organism |
---|---|---|
C111A | contrary to wild-type, presence of 2-mercaptoethanol does not decrease Km value for substrate and NAD+ | Homo sapiens |
C111S | contrary to wild-type, presence of 2-mercaptoethanol does not decrease Km value for substrate and NAD+ | Homo sapiens |
C72F | contrary to wild-type, presence of 2-mercaptoethanol does not decrease Km value for substrate and NAD+ | Homo sapiens |
C72S | contrary to wild-type, presence of 2-mercaptoethanol does not decrease Km value for substrate and NAD+ | Homo sapiens |
C83A | 2-5fold increase in Km values | Homo sapiens |
C83S | no catalytic acitivity | Homo sapiens |
C83S | similar to wild-type, presence of 2-mercaptoethanol results in 2.5fold decrease of Km values | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0007 | - |
dehydroepiandrosterone | wild-type, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.0028 | - |
dehydroepiandrosterone | mutant C72S, pH 7.4 | Homo sapiens | |
0.0037 | - |
dehydroepiandrosterone | wild-type, pH 7.4 | Homo sapiens | |
0.0044 | - |
dehydroepiandrosterone | mutant C72S, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.0075 | - |
dehydroepiandrosterone | mutant C83A, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.0115 | - |
dehydroepiandrosterone | mutant C72F, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.012 | - |
NAD+ | wild-type, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.0127 | - |
dehydroepiandrosterone | mutant C72F, pH 7.4 | Homo sapiens | |
0.0153 | - |
NAD+ | mutant C72S, pH 7.4 | Homo sapiens | |
0.0166 | - |
NAD+ | mutant C111S, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.0168 | - |
dehydroepiandrosterone | mutant C111S, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.0171 | - |
dehydroepiandrosterone | mutant C83A, pH 7.4 | Homo sapiens | |
0.0181 | - |
dehydroepiandrosterone | mutant C111S, pH 7.4 | Homo sapiens | |
0.019 | - |
NAD+ | mutant C111S, pH 7.4 | Homo sapiens | |
0.0194 | - |
NAD+ | mutant C72S, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.0227 | - |
NAD+ | mutant C111A, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.0237 | - |
dehydroepiandrosterone | mutant C111A, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.0255 | - |
NAD+ | mutant C111A, pH 7.4 | Homo sapiens | |
0.0268 | - |
dehydroepiandrosterone | mutant C111A, pH 7.4 | Homo sapiens | |
0.0299 | - |
NAD+ | mutant C83A, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.0341 | - |
NAD+ | wild-type, pH 7.4 | Homo sapiens | |
0.0468 | - |
NAD+ | mutant C72F, pH 7.4 | Homo sapiens | |
0.0476 | - |
NAD+ | mutant C72F, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.0732 | - |
NAD+ | mutant C83A, pH 7.4 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
type 1 enzyme | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone + NAD+ | - |
Homo sapiens | androst-5-en-3,17-dione + NADH + H+ | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
dehydroepiandrosterone | wild-type, pH 7.4 | Homo sapiens | |
0.02 | - |
NAD+ | wild-type, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.021 | - |
dehydroepiandrosterone | wild-type, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.022 | - |
NAD+ | wild-type, pH 7.4 | Homo sapiens | |
0.03 | - |
dehydroepiandrosterone | mutant C111S, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.031 | - |
NAD+ | mutant C111S, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.032 | - |
dehydroepiandrosterone | mutant C111S, pH 7.4 | Homo sapiens | |
0.033 | - |
NAD+ | mutant C111S, pH 7.4 | Homo sapiens | |
0.04 | - |
NAD+ | mutant C111A, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.043 | - |
NAD+ | mutant C72S, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.047 | - |
dehydroepiandrosterone | mutant C111A, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.047 | - |
NAD+ | mutant C72S, pH 7.4 | Homo sapiens | |
0.048 | - |
NAD+ | mutant C83A, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.048 | - |
dehydroepiandrosterone | mutant C83A, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.05 | - |
dehydroepiandrosterone | mutant C72S, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.053 | - |
dehydroepiandrosterone | mutant C72S, pH 7.4 | Homo sapiens | |
0.055 | - |
dehydroepiandrosterone | mutant C83A, pH 7.4 | Homo sapiens | |
0.057 | - |
NAD+ | mutant C83A, pH 7.4 | Homo sapiens | |
0.06 | - |
dehydroepiandrosterone | mutant C111A, pH 7.4 | Homo sapiens | |
0.063 | - |
NAD+ | mutant C111A, pH 7.4 | Homo sapiens | |
0.087 | - |
NAD+ | mutant C72F, pH 7.4 | Homo sapiens | |
0.087 | - |
dehydroepiandrosterone | mutant C72F, pH 7.4 | Homo sapiens | |
0.087 | - |
NAD+ | mutant C72F, presence of 2-mercatoethanol pH 7.4 | Homo sapiens | |
0.087 | - |
dehydroepiandrosterone | mutant C72F, presence of 2-mercatoethanol pH 7.4 | Homo sapiens |