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Literature summary for 1.1.1.145 extracted from

  • Thomas, J.L.; Strickler, R.C.; Myers, R.P.; Covey, D.F
    Affinity labeling of human placental 3beta-hydroxy-DELTA5-steroid dehydrogenase and steroid delta-isomerase: evidence for bifunctional catalysis by a different conformation of the same protein for each enzyme activity (1992), Biochemistry, 31, 5522-5527.
    View publication on PubMed
Search for more literature for 1.1.1.145

Inhibitors

Inhibitors Comment Organism Structure
5,10-Secoestr-4-yne-3,10,17-trione irreversible Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dehydroepiandrosterone + NAD+ Homo sapiens
-
 androst-5-en-3,17-dione + NADH + H+
-
 ?
pregnenolone + NAD(P)+ Homo sapiens
-
 pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+
-
 Homo sapiens 17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H
-
 ?
dehydroepiandrosterone + NAD+
-
 Homo sapiens androst-5-en-3,17-dione + NADH + H+
-
 ?
pregnenolone + NAD(P)+
-
 Homo sapiens pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens
NADP+
-
 Homo sapiens