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Literature summary for 1.1.1.141 extracted from

  • Kim, H.; Lee, H.; Lim, K.; Surh, Y.; Na, H.
    15-Deoxy-DELTA12,14-prostaglandin J2 induces expression of 15-hydroxyprostaglandin dehydrogenase through Elk-1 activation in human breast cancer MDA-MB-231 cells (2014), Mutat. Res., 768, 6-15.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prostaglandin E2 + NAD+ Homo sapiens
-
 15-oxoprostaglandin E2 + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P15428
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prostaglandin E2 + NAD+
-
 Homo sapiens 15-oxoprostaglandin E2 + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
15-PGDH
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens 15-deoxy-DELTA(12,14)-prostaglandin J2 upregulates the expression and the activity of the enzyme through reactive oxygen species-mediated activation of extracellular-signal related kinase1/2 and subsequently Elk-1 in human breast cancer MDA-MB-231 cells up