Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli as a His-tagged fusion protein | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4-([(4-chlorophenyl)sulfanyl]methyl)phenyl)(4-methylpiperidin-1-yl)methanone | - |
Homo sapiens | |
(4-[(2-bromophenoxy)methyl]phenyl)(piperidin-1-yl)methanone | - |
Homo sapiens | |
2-([(6-bromo-4H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]methyl)benzonitrile | - |
Homo sapiens | |
3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | - |
Homo sapiens | |
[1-(3-methylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | - |
Homo sapiens | |
[4-(4-methoxyphenyl)piperazin-1-yl](4-[(phenylsulfanyl)methyl]phenyl)methanone | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0028 | - |
prostaglandin E2 | pH 8.0, 25°C, 20 nM [1-(3-methylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | Homo sapiens | |
0.0037 | - |
prostaglandin E2 | pH 8.0, 25°C, 10 nM [1-(3-methylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | Homo sapiens | |
0.0055 | - |
prostaglandin E2 | pH 8.0, 25°C | Homo sapiens | |
0.0056 | - |
prostaglandin E2 | pH 8.0, 25°C, 4 nM 3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | Homo sapiens | |
0.0064 | - |
prostaglandin E2 | pH 8.0, 25°C, 10 nM 3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | Homo sapiens | |
0.0075 | - |
prostaglandin E2 | pH 8.0, 25°C, 10 nM 2-([(6-bromo-4H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]methyl)benzonitrile | Homo sapiens | |
0.0135 | - |
prostaglandin E2 | pH 8.0, 25°C, 10 nM 2-([(6-bromo-4H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]methyl)benzonitrile | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prostaglandin E2 + NAD+ | - |
Homo sapiens | 15-oxoprostaglandin E2 + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
15-hydroxyprostaglandin dehydrogenase | - |
Homo sapiens |
15-PGDH | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
41.2 | - |
melting point at pH 8.0, ligand free | Homo sapiens |
45.9 | - |
melting point at pH 8.0, in the presence of NAD+ | Homo sapiens |
52.5 | - |
melting point at pH 8.0, in the presence of NADH | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
6.1 | - |
prostaglandin E2 | pH 8.0, 25°C, 20 nM [1-(3-methylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | Homo sapiens | |
7.5 | - |
prostaglandin E2 | pH 8.0, 25°C, 10 nM 3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | Homo sapiens | |
10.3 | - |
prostaglandin E2 | pH 8.0, 25°C, 10 nM [1-(3-methylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | Homo sapiens | |
11.1 | - |
prostaglandin E2 | pH 8.0, 25°C, 4 nM 3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | Homo sapiens | |
12.4 | - |
prostaglandin E2 | pH 8.0, 25°C, 10 nM 2-([(6-bromo-4H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]methyl)benzonitrile | Homo sapiens | |
13.6 | - |
prostaglandin E2 | pH 8.0, 25°C | Homo sapiens | |
14.1 | - |
prostaglandin E2 | pH 8.0, 25°C, 10 nM 2-([(6-bromo-4H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]methyl)benzonitrile | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000056 | - |
pH 8, 25°C | Homo sapiens | [1-(3-methylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | |
0.000089 | - |
pH 8, 25°C | Homo sapiens | (4-[(2-bromophenoxy)methyl]phenyl)(piperidin-1-yl)methanone | |
0.000141 | - |
pH 8, 25°C | Homo sapiens | 2-([(6-bromo-4H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]methyl)benzonitrile | |
0.000631 | - |
pH 8, 25°C | Homo sapiens | (4-([(4-chlorophenyl)sulfanyl]methyl)phenyl)(4-methylpiperidin-1-yl)methanone | |
0.00089 | - |
pH 8, 25°C | Homo sapiens | 3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | |
0.01 | - |
value above, pH 8, 25°C | Homo sapiens | [4-(4-methoxyphenyl)piperazin-1-yl](4-[(phenylsulfanyl)methyl]phenyl)methanone |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
900 | - |
prostaglandin E2 | pH 8.0, 25°C, 10 nM 2-([(6-bromo-4H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]methyl)benzonitrile | Homo sapiens | |
1200 | - |
prostaglandin E2 | pH 8.0, 25°C, 10 nM 3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | Homo sapiens | |
1800 | - |
prostaglandin E2 | pH 8.0, 25°C, 10 nM 2-([(6-bromo-4H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]methyl)benzonitrile | Homo sapiens | |
2000 | - |
prostaglandin E2 | pH 8.0, 25°C, 4 nM 3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | Homo sapiens | |
2100 | - |
prostaglandin E2 | pH 8.0, 25°C, 20 nM [1-(3-methylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | Homo sapiens | |
2500 | - |
prostaglandin E2 | pH 8.0, 25°C | Homo sapiens | |
2800 | - |
prostaglandin E2 | pH 8.0, 25°C, 10 nM [1-(3-methylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone | Homo sapiens |