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Literature summary for 1.1.1.141 extracted from

  • Pham, H.; Eibl, G.; Vincenti, R.; Chong, B.; Tai, H.H.; Slice, L.W.
    15-Hydroxyprostaglandin dehydrogenase suppresses K-RasV12-dependent tumor formation in Nu/Nu mice (2008), Mol. Carcinog., 47, 466-477.
    View publication on PubMed
Search for more literature for 1.1.1.141

Application

Application Comment Organism
medicine expression in nontumorigenic IEC-18 cells, with and without K-RasV12 and analysis of the ability of cells to form tumors in nu/nu mice. Transformed cells show increased 15-hydroxyprostaglandin dehydrogenase activity with decreased prostaglandin E2 and prostaglandin I2 levels, cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and proliferation rates. Xenografts of cells expressing both the enzyme and K-RasV12 exhibit delayed tumor formation with negligible cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and significantly decreased prostaglandin E2 levels. Tumors have decreased staining of the proliferative marker, Ki-67, and a significant increase in apoptosis in the central region of the tumor Rattus norvegicus
medicine PGDH expression suppresses K-RasV12-mediated tumorigenesis in intestinal epithelial cells Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression in IEC-18 cell Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information expression in nontumorigenic IEC-18 cells, with and without K-RasV12 and analysis of the ability of cells to form tumors in nu/nu mice. Transformed cells show increased 15-hydroxyprostaglandin dehydrogenase activity with decreased prostaglandin E2 and prostaglandin I2 levels, cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and proliferation rates. Xenografts of cells expressing both the enzyme and K-RasV12 exhibit delayed tumor formation with negligible cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and significantly decreased prostaglandin E2 levels. Tumors have decreased staining of the proliferative marker, Ki-67, and a significant increase in apoptosis in the central region of the tumor Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
5-[[4-(ethoxycarbonyl)phenyl]azo]2-hydroxy-benzene acetic acid CAY-10397 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus O08699
-
-

Source Tissue

Source Tissue Comment Organism Textmining
IEC-18 cell
-
 Rattus norvegicus
-
intestinal epithelium
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prostaglandin E2 + NAD+
-
 Rattus norvegicus 15-ketoprostaglandin E2 + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
15-PGDH
-
 Rattus norvegicus
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+ dependent on Rattus norvegicus