Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | 15-PGDH expression is increased by hepatocyte nuclear factor 3beta in lung cancer cells | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | loss of 15-hydroxyprostaglandin expression in 65% of lung cancers. Enzyme acts as a tumor suppressor in lung cancer and is a direct downstream effector of hepatocyte nuclear factor 3beta | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
Y151L/K155E | inactive | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
Calu-1 cell | - |
Homo sapiens | - |
Calu-6 cell | - |
Homo sapiens | - |
lung cancer cell | - |
Homo sapiens | - |
lung cancer cell | loss of 15-hydroxyprostaglandin expression in 65% of lung cancers. Enzyme acts as a tumor suppressor in lung cancer | Homo sapiens | - |
NCI-H125 cell | - |
Homo sapiens | - |
NCI-H211 cell | - |
Homo sapiens | - |
NCI-H23 cell | - |
Homo sapiens | - |
NCI-H292 cell | - |
Homo sapiens | - |
NCI-H322 cell | - |
Homo sapiens | - |
NCI-H358 cell | - |
Homo sapiens | - |
NCI-H441 cell | - |
Homo sapiens | - |
NCI-H460 cell | - |
Homo sapiens | - |
NCI-H661 cell | - |
Homo sapiens | - |
NCI-H69 cell | - |
Homo sapiens | - |
non-small cell lung cancer cell | - |
Homo sapiens | - |
SK-LU-1 cell | - |
Homo sapiens | - |
SK-MES-1 cell | - |
Homo sapiens | - |
SW-900 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
15-hydroxyprostaglandin + NAD+ | - |
Homo sapiens | 15-oxoprostaglandin + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
15-hydroxyprostaglandin dehydrogenase | - |
Homo sapiens |
15-PGDH | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | dependent on | Homo sapiens |