Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | enzyme expression is inducible by indomethacin in LS174T cells, but not in HCA-7 and HCT-15 cells, and also not in enzyme-deficient HCT-116 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | Mus musculus | PGE2 degradation | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | Homo sapiens | PGE2 degradation | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene 15-Pgdh | - |
Mus musculus | - |
gene 15-Pgdh | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bladder | - |
Homo sapiens | - |
colorectal cancer cell | the enzyme expression is down-regulated | Homo sapiens | - |
DLD-1 cell | low enzyme expression level | Homo sapiens | - |
embryo | low enzyme expression level | Mus musculus | - |
HCA-7 cell | low enzyme expression level | Homo sapiens | - |
HCT-15 cell | - |
Homo sapiens | - |
HT-29 cell | very low enzyme expression level | Homo sapiens | - |
kidney | very low expression level | Homo sapiens | - |
kidney | low enzyme expression level | Mus musculus | - |
liver | - |
Homo sapiens | - |
liver | high enzyme expression level | Mus musculus | - |
LoVo cell | - |
Homo sapiens | - |
LS174T cell | very low enzyme expression level | Homo sapiens | - |
lung | - |
Homo sapiens | - |
lung | high enzyme expression level | Mus musculus | - |
additional information | distribution of enzyme expression in normal and pathological tissues, overview, no enzyme expression in spleen, heart, HCT-116 cells, CacO-2 cells and Colo 201 cells | Homo sapiens | - |
additional information | tissue distribution of enzyme expression, overview, no expression in heart and brain | Mus musculus | - |
ovary | low enzyme expression level | Mus musculus | - |
prostate gland | very low expression level | Homo sapiens | - |
small intestine | - |
Homo sapiens | - |
spleen | low enzyme expression level | Mus musculus | - |
SW-480 cell | very low enzyme expression level | Homo sapiens | - |
testis | very low enzyme expression level | Mus musculus | - |
thymus | low enzyme expression level | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | PGE2 degradation | Mus musculus | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | PGE2 degradation | Homo sapiens | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | i.e. 15-hydroxyprostaglandin or PGE2 | Mus musculus | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | i.e. 15-hydroxyprostaglandin or PGE2 | Homo sapiens | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
15-hydroxyprostaglandin dehydrogenase | - |
Mus musculus |
15-hydroxyprostaglandin dehydrogenase | - |
Homo sapiens |
15-PGDH | - |
Mus musculus |
15-PGDH | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Mus musculus | |
NAD+ | - |
Homo sapiens |