Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | no activation by cAMP | Canis lupus familiaris |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition by Ca2+ | Canis lupus familiaris | |
papaverine | the inhibition is noncompetitive with prostaglandin E2, uncompetitive with NAD+, and reversible | Canis lupus familiaris | |
papaverine | the inhibition is noncompetitive with prostaglandin E2, uncompetitive with NAD+, and reversible | Cavia porcellus | |
papaverine | - |
Gallus gallus | |
papaverine | the inhibition is noncompetitive with prostaglandin E2, uncompetitive with NAD+, and reversible | Rattus norvegicus | |
papaverine | the inhibition is noncompetitive with prostaglandin E2, uncompetitive with NAD+, and reversible | Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | pH 7.4, 37°C | Cavia porcellus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Cavia porcellus | - |
- |
soluble | - |
Sus scrofa | - |
- |
soluble | - |
Canis lupus familiaris | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | Cavia porcellus | first step in prostaglandin catabolism | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | Rattus norvegicus | first step in prostaglandin catabolism | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | Sus scrofa | first step in prostaglandin catabolism | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | Canis lupus familiaris | first step in prostaglandin catabolism | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Cavia porcellus | - |
- |
- |
Gallus gallus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme partially from heart | Cavia porcellus |
native enzyme partially from kidney | Rattus norvegicus |
native soluble enzyme partially from heart ventricular tissue by ultracentrifugation, ammonium sulfate fractionation, gel filtration, and anion exchange chromatography | Canis lupus familiaris |
native soluble enzyme partially from lung | Sus scrofa |
native soluble enzyme partially from lung by ultracentrifugation, ammonium sulfate fractionation and anion exchange chromatography | Cavia porcellus |
partial | Gallus gallus |
partial | Cavia porcellus |
partial | Rattus norvegicus |
partial | Sus scrofa |
partial | Canis lupus familiaris |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Gallus gallus | - |
heart | - |
Cavia porcellus | - |
heart | - |
Rattus norvegicus | - |
heart | - |
Sus scrofa | - |
heart | - |
Canis lupus familiaris | - |
kidney | - |
Gallus gallus | - |
kidney | - |
Cavia porcellus | - |
kidney | - |
Rattus norvegicus | - |
kidney | - |
Sus scrofa | - |
kidney | - |
Canis lupus familiaris | - |
lung | - |
Cavia porcellus | - |
lung | - |
Rattus norvegicus | - |
lung | - |
Sus scrofa | - |
lung | - |
Canis lupus familiaris | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | first step in prostaglandin catabolism | Cavia porcellus | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | first step in prostaglandin catabolism | Rattus norvegicus | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | first step in prostaglandin catabolism | Sus scrofa | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | first step in prostaglandin catabolism | Canis lupus familiaris | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | i.e. 15-hydroxyprostaglandin or (15S)-PGE2 | Cavia porcellus | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | i.e. 15-hydroxyprostaglandin or (15S)-PGE2 | Rattus norvegicus | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | i.e. 15-hydroxyprostaglandin or (15S)-PGE2 | Sus scrofa | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | i.e. 15-hydroxyprostaglandin or (15S)-PGE2 | Canis lupus familiaris | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
15-hydroxyprostaglandin dehydrogenase | - |
Cavia porcellus |
15-hydroxyprostaglandin dehydrogenase | - |
Rattus norvegicus |
15-hydroxyprostaglandin dehydrogenase | - |
Sus scrofa |
15-hydroxyprostaglandin dehydrogenase | - |
Canis lupus familiaris |
15-OH-PGDH | - |
Cavia porcellus |
15-OH-PGDH | - |
Rattus norvegicus |
15-OH-PGDH | - |
Sus scrofa |
15-OH-PGDH | - |
Canis lupus familiaris |
NAD+-linked 15-hydroxyprostaglandin dehydrogenase | - |
Cavia porcellus |
NAD+-linked 15-hydroxyprostaglandin dehydrogenase | - |
Rattus norvegicus |
NAD+-linked 15-hydroxyprostaglandin dehydrogenase | - |
Sus scrofa |
NAD+-linked 15-hydroxyprostaglandin dehydrogenase | - |
Canis lupus familiaris |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Cavia porcellus |
37 | - |
assay at | Rattus norvegicus |
37 | - |
assay at | Sus scrofa |
37 | - |
assay at | Canis lupus familiaris |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Cavia porcellus |
7.4 | - |
assay at | Rattus norvegicus |
7.4 | - |
assay at | Sus scrofa |
8.7 | - |
assay at | Canis lupus familiaris |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Cavia porcellus | |
NAD+ | - |
Rattus norvegicus | |
NAD+ | - |
Sus scrofa | |
NAD+ | - |
Canis lupus familiaris |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.026 | - |
papaverine | - |
Cavia porcellus | |
0.026 | - |
papaverine | pH 7.4, 37°C | Cavia porcellus | |
0.068 | - |
papaverine | enzyme from kidney | Canis lupus familiaris | |
0.068 | - |
papaverine | kidney enzyme, pH 7.4, 37°C | Canis lupus familiaris | |
0.07 | - |
papaverine | enzyme from heart | Canis lupus familiaris | |
0.07 | - |
papaverine | heart enzyme, pH 7.4, 37°C | Canis lupus familiaris | |
0.098 | - |
papaverine | - |
Gallus gallus | |
0.098 | - |
papaverine | pH 7.4, 37°C | Cavia porcellus | |
0.12 | - |
papaverine | - |
Sus scrofa | |
0.12 | - |
papaverine | pH 7.4, 37°C | Sus scrofa | |
0.4 | - |
papaverine | - |
Rattus norvegicus | |
0.4 | - |
papaverine | kidney enzyme, pH 7.4, 37°C | Rattus norvegicus |