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Literature summary for 1.1.1.14 extracted from
- Inhibition and activation studies on sheep liver sorbitol dehydrogenase (1994), Eur. J. Biochem., 221, 847-854.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| (R)-(-)-2-octanol | at pH 9.9 | Ovis aries |  |
| (S)-(+)-2-octanol | at pH 9.9 | Ovis aries | |
| 1-Hexanol | - |
Ovis aries | |
| 1-Octanol | - |
Ovis aries | |
| 2,2,2-tribromoethanol | - |
Ovis aries | |
| 2,2,2-trichloroethanol | - |
Ovis aries | |
| 2,2,2-Trifluoroethanol | - |
Ovis aries | |
| 2-monobromoethanol | - |
Ovis aries | |
| 2-monochloroethanol | - |
Ovis aries | |
| 2-monofluoroethanol | - |
Ovis aries | |
| NaBr | - |
Ovis aries | |
| NaCl | - |
Ovis aries | |
| NaI | - |
Ovis aries | |
| SDS | - |
Ovis aries | |
| sodium taurodeoxycholate | - |
Ovis aries | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (2S)-1-(3-thio-2-methylpropionyl)-L-proline | - |
Ovis aries | |
| 1,10-phenanthroline | - |
Ovis aries | |
| 1,2,3,4,5,6-cyclohexanehexolphosphoric acid | at pH 9.9 | Ovis aries | |
| 1,2-dithioethane | - |
Ovis aries | |
| 1,7-phenanthroline | - |
Ovis aries | |
| 1-thiobutane | - |
Ovis aries | |
| 1-thioglycol | - |
Ovis aries | |
| 1-thiosorbitol | - |
Ovis aries | |
| 2,2'-dipyridyl | - |
Ovis aries | |
| 2,3-Dithiopropanol | - |
Ovis aries | |
| 2-hydroxybenzoic acid | at pH 9.9 | Ovis aries | |
| 2-mercaptoethanol | - |
Ovis aries | |
| 2-methypropanoic acid amide | at pH 9.9 | Ovis aries | |
| 2-propylpentanoic acid | at pH 9.9 | Ovis aries | |
| 2-thiobutane | - |
Ovis aries | |
| 3,4-dihydroxyphenyl-1-hydroxyacetic acid | at pH 7.4 | Ovis aries | |
| 3,4-dihydroxyphenyl-ethanediol | at pH 7.4 | Ovis aries | |
| 3-hydroxy-4-methoxy-phenyl-1-hydroxy-acetic acid | at pH 7.4 | Ovis aries | |
| 4,4'-dipyridyl | - |
Ovis aries | |
| 4-hydroxy-3-methoxy-phenyl-1-hydroxy-acetic acid | at pH 7.4 | Ovis aries | |
| 4-hydroxy-3-methoxy-phenylacetic acid | at pH 7.4 | Ovis aries | |
| 4-hydroxy-3-methoxy-phenylethanediol | at pH 7.4 | Ovis aries | |
| 4-hydroxy-3-methoxy-phenylethyl alcohol | at pH 7.4 | Ovis aries | |
| 8-hydroxyquinoline | - |
Ovis aries | |
| acetic acid amide | at pH 9.9 | Ovis aries | |
| Alrestatin | - |
Ovis aries | |
| Berberine | - |
Ovis aries | |
| bis-diethylthiocarbamoyldisulfide | - |
Ovis aries | |
| butanedioic acid | at pH 9.9 | Ovis aries | |
| Cibacron Blue 3G-A | - |
Ovis aries | |
| cyanamide | at pH 9.9 | Ovis aries | |
| cysteamine | significant only at pH 9.9 | Ovis aries | |
| cysteine | - |
Ovis aries | |
| Decanoic acid | at pH 9.9 | Ovis aries | |
| Diethylthiocarbamate | at pH 9.9 | Ovis aries | |
| dithiothreitol | - |
Ovis aries | |
| DL-2-thiovaline | - |
Ovis aries | |
| Eriochrome Black T | - |
Ovis aries | |
| ethanedioic acid | at pH 9.9 | Ovis aries | |
| ICI 171071 | - |
Ovis aries | |
| ICI 222155 | - |
Ovis aries | |
| imidazole | - |
Ovis aries | |
| Isonicotinic acid hydrazide | - |
Ovis aries | |
| ponalrestat | - |
Ovis aries | |
| propanedioic acid | at pH 9.9 | Ovis aries | |
| pyrazole | - |
Ovis aries | |
| quercetin | at pH 7.4 | Ovis aries | |
| thioacetate | at pH 9.9 | Ovis aries | |
| thiocyanate | at pH 9.9 | Ovis aries | |
| Thiourea | at pH 9.9 | Ovis aries | |
| Tolrestat | - |
Ovis aries | |
| Urea | at pH 9.9 | Ovis aries | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ovis aries | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Ovis aries | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-sorbitol + NAD+ | - |
Ovis aries | D-fructose + NADH + H+ | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Ovis aries | |
| NADH | - |
Ovis aries | |
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