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Literature summary for 1.1.1.132 extracted from
- Influence of macrolides on guanosine diphospho-D-mannose dehydrogenase activity in Pseudomonas biofilm (2000), J. Infect. Chemother., 6, 45-50.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| erythromycin | potent dose-dependent inhibitory effect, inhibition of biofilm formation, PT-1578 | Pseudomonas aeruginosa |  |
| midecamycin | weaker inhibition, no biofilm destruction, PT-1578 | Pseudomonas aeruginosa | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas aeruginosa | - |
mucoid clinical isolate PT-1578 and non-mucoid PAO1, very low activity of PAO1 regardless whether using nutrient-rich or poor medium, low activity with PT-1578 on enriched, increased on nutritionally poor medium | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GDP-mannose + NAD+ + H2O | - |
Pseudomonas aeruginosa | GDP-mannuronate + NADH | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Pseudomonas aeruginosa | |
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Release 2023.1 (January 2023)
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