Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0011 | - |
all-trans-retinol | 37°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-retinol + NAD+ | Homo sapiens | RoDH-4 is capable of contributing to the oxidation of retinol to retinaldehyde for retinoic acid biosynthesis in the cellular context | all-trans-retinal + NADH | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O75452 | - |
- |
Purification (Comment) | Organism |
---|---|
preparation of RoDH-4 contains a minor contaminating protein band. Therefore, the exact concentration of RoDH-4 is determined based on the calibration curve constructed from several concentrations of BSA loaded on to the same SDS/PAGE gel | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-retinol + NAD+ | RoDH-4 is capable of contributing to the oxidation of retinol to retinaldehyde for retinoic acid biosynthesis in the cellular context | Homo sapiens | all-trans-retinal + NADH | - |
? | |
all-trans-retinol + NAD+ | - |
Homo sapiens | all-trans-retinal + NADH + H+ | - |
? | |
additional information | the enzymes utilizes retinol bound to cellular retinol binding protein type I at a much lower rate than free retinol | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RoDH-4 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
all-trans-retinol | 37°C | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | preferred cofactor | Homo sapiens |