Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Chloral hydrate | - |
Rattus norvegicus | |
additional information | chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition | Peromyscus maniculatus | |
additional information | chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition | Rattus norvegicus | |
SKF525A | moderately | Peromyscus maniculatus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition | ? | - |
? | |
additional information | Peromyscus maniculatus | chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Peromyscus maniculatus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
liver | - |
Peromyscus maniculatus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition | Rattus norvegicus | ? | - |
? | |
additional information | chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition | Peromyscus maniculatus | ? | - |
? | |
retinal + NADH | - |
Rattus norvegicus | retinol + NAD+ | - |
r | |
retinal + NADH | - |
Peromyscus maniculatus | retinol + NAD+ | - |
r | |
retinal + NADPH + H+ | - |
Rattus norvegicus | retinol + NADP+ | - |
? | |
retinol + NADP+ | - |
Peromyscus maniculatus | retinal + NADPH | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | cofactor | Rattus norvegicus | |
NAD+ | cofactor | Peromyscus maniculatus | |
NADH | cofactor | Rattus norvegicus | |
NADH | cofactor | Peromyscus maniculatus | |
NADP+ | cofactor | Peromyscus maniculatus | |
NADPH | cofactor | Rattus norvegicus | |
NADPH | cofactor | Peromyscus maniculatus |