Literature summary for 1.1.1.100 extracted from

Karioti, A.; Skaltsa, H.; Zhang, X.; Tonge, P.J.; Perozzo, R.; Kaiser, M.; Franzblau, S.G.; Tasdemir, D.
Inhibiting enoyl-ACP reductase (FabI) across pathogenic microorganisms by linear sesquiterpene lactones from Anthemis auriculata (2008), Phytomedicine, 15, 1125-1129.

Search for more literature for 1.1.1.100

Inhibitors

Inhibitors	Comment	Organism	Structure
4-acetoxyanthecotulide	most active linear sesquiterpene lactone from Anthemis auriculata against FabG	Plasmodium falciparum K1
4-hydroxyanthecotulide	linear sesquiterpene lactone from Anthemis auriculata	Plasmodium falciparum K1
anthecotulide	linear sesquiterpene lactone from Anthemis auriculata	Plasmodium falciparum K1

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum K1	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetoacetyl-CoA + NADPH	-	Plasmodium falciparum K1	3-hydroxybutyryl-CoA + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
beta-ketoacyl-ACP reductase	-	Plasmodium falciparum K1
FabG	-	Plasmodium falciparum K1

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Plasmodium falciparum K1

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.5	-	pH 7.0, 25°C	Plasmodium falciparum K1	4-acetoxyanthecotulide
0.75	-	pH 7.0, 25°C	Plasmodium falciparum K1	4-hydroxyanthecotulide
1	-	pH 7.0, 25°C	Plasmodium falciparum K1	anthecotulide

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Release 2023.1 (January 2023)