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Literature summary for 1.1.1.1 extracted from
- NAD+-linked alcohol dehydrogenase 1 regulates methylglyoxal concentration in Candida albicans (2014), FEBS Lett., 588, 1144-1153 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene ADH1, sequence comparisons | Candida albicans |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | generation of ADH1 gene disruption mutants | Candida albicans |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| methylglyoxal + NADH + H+ | Candida albicans | - |
acetol + NAD+ | - |
r |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Candida albicans | A0A1D8PP43 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| methylglyoxal + NADH + H+ | - |
Candida albicans | acetol + NAD+ | - |
r | |
| additional information | Candida albicans ADH1 is a bifunctional enzyme that catalyzes methylglyoxal oxidation and reduction, cf. EC 1.2.1.23 | Candida albicans | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADH1 | - |
Candida albicans |
| alpha-ketoaldehyde dehydrogenase | - |
Candida albicans |
| MGD | - |
Candida albicans |
| NAD+-linked alcohol dehydrogenase 1 | - |
Candida albicans |
| NAD+-linked methylglyoxal dehydrogenase | - |
Candida albicans |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | specific for | Candida albicans | |
| NADH | - |
Candida albicans | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Candida albicans | the enzyme activity is highly induced in glutathione GSH-deficient cells | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | methylglyoxal accumulation leads to G2-phase arrest by affecting cell growth, ROS production, viability, differentiation, and virulence. Phenotypes of enzyme-deficient cells, overview | Candida albicans |
| physiological function | the enzyme catalyzes both methylglyoxal oxidation to pyruvate as well as its reduction to acetol. ADH1 activity likely shifts between methylglyoxal oxidation and reduction with a marked change in the intracellular redox state during the growth, such as GSH starvation. The enzyme is required for regulation of methylglyoxal content in the cell. Mgd activity is highly induced in GSH-deficient cells | Candida albicans |
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Release 2023.1 (January 2023)
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