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Literature summary for 1.1.1.1 extracted from

  • Yin, S.J.; Wang, M.F.; Liao, C.S.; Chen, C.M.; Wu, C.W.
    Identification of a human stomach alcohol dehydrogenase with distinctive kinetic properties (1990), Biochem. Int., 22, 829-835.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-Methylpyrazole competitive against ethanol Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.044
-
Pentanol
-
Homo sapiens
0.047
-
12-hydroxydodecanoate
-
Homo sapiens
0.15
-
benzyl alcohol
-
Homo sapiens
0.24
-
butanol
-
Homo sapiens
0.34
-
NAD+
-
Homo sapiens
0.91
-
Propanol
-
Homo sapiens
18
-
ethanol
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc enzyme contains 7.59 zinc atoms per molecule Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ethanol + NAD+ Homo sapiens the enzyme plays a significant role in first-pass metabolism of ethanol in human acetaldehyde + NADH
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
mue-alcolhol dehydrogenase
-

Source Tissue

Source Tissue Comment Organism Textmining
stomach stomach mucosa, mue-alcohol dehydrogenase Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
12-hydroxydodecanoate + NAD+
-
Homo sapiens 12-oxododecanoic acid + NADH
-
?
benzyl alcohol + NAD+
-
Homo sapiens benzaldehyde + NADH
-
?
butanol + NAD+
-
Homo sapiens butyraldehyde + NADH
-
?
ethanol + NAD+
-
Homo sapiens acetaldehyde + NADH
-
?
ethanol + NAD+ the enzyme plays a significant role in first-pass metabolism of ethanol in human Homo sapiens acetaldehyde + NADH
-
?
pentanal + NAD+
-
Homo sapiens pentanone + NADH
-
?
propanol + NAD+
-
Homo sapiens propionaldehyde + NADH + H+
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
10
-
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
8 10.5 pH 8.0: about 40% of maximal activity, pH 10.5: about 85% of maximal activity Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NADH
-
Homo sapiens