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ATP + 3-methylcrotonyl-CoA + HCO3-
?
-
4-8% of the activity relative to (Z)-geranoyl-CoA
-
-
?
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
geranoyl-CoA is preferred over 3-methylcrotonyl-CoA as substrate
-
-
?
ATP + dimethylacryl-CoA + HCO3-
?
-
-
-
-
?
ATP + ethylcrotonyl-CoA + HCO3-
?
-
cis-ethylcrotonyl-CoA and trans-ethylcrotonyl-CoA
-
-
?
ATP + farnesyl-CoA + HCO3-
?
ATP + geranoyl-CoA + HCO3-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
additional information
?
-
ATP + farnesyl-CoA + HCO3-
?
-
-
-
-
?
ATP + farnesyl-CoA + HCO3-
?
-
36% of the activity relative to (Z)-geranoyl-CoA
-
-
?
ATP + geranoyl-CoA + HCO3-
?
-
one of the unique enzymes in the isoprenol degradative pathway
-
-
?
ATP + geranoyl-CoA + HCO3-
?
-
geranoyl-CoA carboxylase initiates the degradation of the branched carbon skeleton of geraniol, citronellol and farnesol
-
-
?
ATP + geranoyl-CoA + HCO3-
?
-
one of the unique enzymes in the isoprenol degradative pathway
-
-
?
ATP + geranoyl-CoA + HCO3-
?
-
one of the unique enzymes in the isoprenol degradative pathway
-
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
ATP-dependent carboxylation of the methyl group that is proximal to the carboxyl end of geranoyl-CoA
formation of gamma-carboxygeranoyl-CoA
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
plays an important role in isoprenoid catabolism
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
ATP-dependent carboxylation of the methyl group that is proximal to the carboxyl end of geranoyl-CoA
formation of gamma-carboxygeranoyl-CoA
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
plays an important role in isoprenoid catabolism
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
-
-
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
involved in isoprenoid catabolism
-
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
the enzyme is involved in leucine/isovalerate utilization and acyclic terpene utilization
-
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
geranyl-coenzyme A (CoA)-carboxylase and methylcrotonyl-CoA-carboxylase are characteristic enzymes of the catabolic pathway of acyclic terpenes (citronellol and geraniol) and of saturated methyl-branched compounds, such as leucine or isovalerate, respectively
-
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
geranoyl-CoA is preferred over 3-methylcrotonyl-CoA as substrate
-
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
the enzyme is involved in leucine/isovalerate utilization and acyclic terpene utilization
-
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
-
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
-
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
-
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
-
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
-
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
(Z)-geranoyl-CoA, no activity with (E)-geranoyl-CoA
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
two-step reaction, ATP-dependent carboxylation of the methyl group that is proximal to the carboxyl end of geranoyl-CoA, domain structure
formation of gamma-carboxygeranoyl-CoA
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
ATP-dependent carboxylation of the methyl group that is proximal to the carboxyl end of geranoyl-CoA
formation of gamma-carboxygeranoyl-CoA
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
two-step reaction, ATP-dependent carboxylation of the methyl group that is proximal to the carboxyl end of geranoyl-CoA, domain structure
formation of gamma-carboxygeranoyl-CoA
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
plays an important role in isoprenoid catabolism
-
?
additional information
?
-
-
geranyl-CoA carboxylase encoded by the atuF gene is induced by citronellol
-
-
?
additional information
?
-
-
the enzymatic properties suggest that geranoyl-CoA carboxylase may substitute for 3-methylcrotonyl-CoA carboxylase in leucine catabolism and that both enzymes play important roles in the leucine and acyclic terpene catabolic pathways
-
-
?
additional information
?
-
-
the enzyme utilizes 5-15-carbon acyl-CoA substrates
-
-
?
additional information
?
-
-
ATP-dependent carboxylation of d-biotin at 3-5% the rate of geranoyl-CoA carboxylation
-
-
?
additional information
?
-
-
may be involved in isoprenoid metabolism, catabolism of acyclic isoprenoids
-
?
additional information
?
-
-
not: methylcrotonyl-CoA
-
?
additional information
?
-
-
may be involved in isoprenoid metabolism, catabolism of acyclic isoprenoids
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + geranoyl-CoA + HCO3-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
additional information
?
-
ATP + geranoyl-CoA + HCO3-
?
-
one of the unique enzymes in the isoprenol degradative pathway
-
-
?
ATP + geranoyl-CoA + HCO3-
?
-
geranoyl-CoA carboxylase initiates the degradation of the branched carbon skeleton of geraniol, citronellol and farnesol
-
-
?
ATP + geranoyl-CoA + HCO3-
?
-
one of the unique enzymes in the isoprenol degradative pathway
-
-
?
ATP + geranoyl-CoA + HCO3-
?
-
one of the unique enzymes in the isoprenol degradative pathway
-
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
plays an important role in isoprenoid catabolism
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
plays an important role in isoprenoid catabolism
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
involved in isoprenoid catabolism
-
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
the enzyme is involved in leucine/isovalerate utilization and acyclic terpene utilization
-
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
geranyl-coenzyme A (CoA)-carboxylase and methylcrotonyl-CoA-carboxylase are characteristic enzymes of the catabolic pathway of acyclic terpenes (citronellol and geraniol) and of saturated methyl-branched compounds, such as leucine or isovalerate, respectively
-
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
the enzyme is involved in leucine/isovalerate utilization and acyclic terpene utilization
-
-
?
ATP + geranoyl-CoA + HCO3-
ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
plays an important role in isoprenoid catabolism
-
?
additional information
?
-
-
geranyl-CoA carboxylase encoded by the atuF gene is induced by citronellol
-
-
?
additional information
?
-
-
the enzymatic properties suggest that geranoyl-CoA carboxylase may substitute for 3-methylcrotonyl-CoA carboxylase in leucine catabolism and that both enzymes play important roles in the leucine and acyclic terpene catabolic pathways
-
-
?
additional information
?
-
-
may be involved in isoprenoid metabolism, catabolism of acyclic isoprenoids
-
?
additional information
?
-
-
may be involved in isoprenoid metabolism, catabolism of acyclic isoprenoids
-
?
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Hector, M.L.; fall, R.R.
Multiple acyl-coenzyme A carboxylases in Pseudomonas citronellolis
Biochemistry
15
3465-3472
1976
Pseudomonas citronellolis
brenda
Fall, R.R.
3-Methylcrotonyl-CoA and geranyl-CoA carboxylases from Pseudomonas citronellolis
Methods Enzymol.
71
791-799
1981
Pseudomonas citronellolis
brenda
Fall, R.R.; Hector, M.L.
Acyl-coenzyme A carboxylases. Homologous 3-methylcrotonyl-CoA and geranyl-CoA carboxylase from Pseudomonas citronellolis
Biochemistry
16
4000-4005
1977
Pseudomonas citronellolis
brenda
Hector, M.L.; Fall, R.R.
Evidence for distinct 3-methylcrotonyl-CoA and geranyl-CoA carboxylases in Pseudomonas citronellolis
Biochem. Biophys. Res. Commun.
71
746-753
1976
Pseudomonas citronellolis
brenda
Seubert, W.; Fass, E.; Remberger, U.
Untersuchungen ber den bakteriellen Abbau von Isoprenoiden. III. Reinigung und Eigenschaften der Geranylcarboxylase
Biochem. Z.
338
265-275
1963
Pseudomonas citronellolis
-
brenda
Cantwell, S.G.; Lau, E.P.; Watt, D.S.; Fall, R.R.
Biodegradation of acyclic isoprenoids by Pseudomonas species
J. Bacteriol.
135
324-333
1978
Pseudomonas aeruginosa, Pseudomonas citronellolis, Pseudomonas mendocina
brenda
Guan, X.; Diez, T.; Prasad, T.K.; Nikolau, B.J.; Wurtele, E.S.
Geranoyl-CoA carboxylase: a novel biotin-containing enzyme in plants
Arch. Biochem. Biophys.
362
12-21
1999
Daucus carota, Glycine max, Zea mays
brenda
Nikolau, B.J.; Ohlrogge, J.B.; Wurtele, E.S.
Plant biotin-containing carboxylases
Arch. Biochem. Biophys.
414
211-222
2003
Pseudomonas sp., Zea mays
brenda
Diaz-Perez, A.L.; Zavala-Hernandez, A.N.; Cervantes, C.; Campos-Garcia, J.
The gnyRDBHAL cluster is involved in acyclic isoprenoid degradation in Pseudomonas aeruginosa
Appl. Environ. Microbiol.
70
5102-5110
2004
Pseudomonas aeruginosa
brenda
Hoschle, B.; Gnau, V.; Jendrossek, D.
Methylcrotonyl-CoA and geranyl-CoA carboxylases are involved in leucine/isovalerate utilization (Liu) and acyclic terpene utilization (Atu), and are encoded by liuB/liuD and atuC/atuF, in Pseudomonas aeruginosa
Microbiology
151
3649-3656
2005
Pseudomonas aeruginosa
brenda
Aguilar, J.A.; Zavala, A.N.; Diaz-Perez, C.; Cervantes, C.; Diaz-Perez, A.L.; Campos-Garcia, J.
The atu and liu clusters are involved in the catabolic pathways for acyclic monoterpenes and leucine in Pseudomonas aeruginosa
Appl. Environ. Microbiol.
72
2070-2079
2006
Pseudomonas aeruginosa
brenda
Foerster-Fromme, K.; Hoeschle, B.; Mack, C.; Bott, M.; Armbruster, W.; Jendrossek, D.
Identification of genes and proteins necessary for catabolism of acyclic terpenes and leucine/isovalerate in Pseudomonas aeruginosa
Appl. Environ. Microbiol.
72
4819-4828
2006
Pseudomonas aeruginosa
brenda
Aguilar, J.A.; Diaz-Perez, C.; Diaz-Perez, A.L.; Rodriguez-Zavala, J.S.; Nikolau, B.J.; Campos-Garcia, J.
Substrate specificity of the 3-methylcrotonyl coenzyme A (CoA) and geranyl-CoA carboxylases from Pseudomonas aeruginosa
J. Bacteriol.
190
4888-4893
2008
Pseudomonas aeruginosa
brenda
Jurado, A.; Huang, C.; Zhang, X.; Zhou, Z.; Tong, L.
Structure and substrate selectivity of the 750-kDa alpha6beta6 holoenzyme of geranyl-CoA carboxylase
Nat. Commun.
6
8986
2015
Pseudomonas aeruginosa (Q9HZV9), Pseudomonas aeruginosa DSM 22644 (Q9HZV9), Pseudomonas fluorescens
brenda