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3-methylcrotonyl-CoA + ATP + HCO3-
3-methylglutaconyl-CoA + ADP + phosphate
ATP + (2Z)-3-ethylcrotonoyl-CoA
ADP + phosphate + 3-ethylglutaconyl-CoA
-
12% of the activity relative to 3-methylcrotonoyl-CoA
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + 3-methylglutaconyl-CoA + phosphate
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
ATP + acetoacetyl-CoA + HCO3-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
r
ATP + crotonoyl-CoA + HCO3-
?
ATP + crotonyl-CoA + HCO3-
ADP + phosphate + glutaconyl-CoA
glutaconyl-CoA + H+
crotonyl-CoA + CO2
-
-
-
r
UTP + 3-methylcrotonoyl-CoA + HCO3-
UDP + phosphate + 3-methylglutaconyl-CoA
-
at 62% of the activity relative to ATP
-
-
?
additional information
?
-
3-methylcrotonyl-CoA + ATP + HCO3-
3-methylglutaconyl-CoA + ADP + phosphate
-
-
-
?
3-methylcrotonyl-CoA + ATP + HCO3-
3-methylglutaconyl-CoA + ADP + phosphate
-
mitochondrial leucine catabolic pathway
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
?
-
induction with 3-methylcrotonoyl-CoA as growth substrate. No activity with 3-methylpentanoate as growth substrate
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
?
-
enzyme of the leucine oxidative pathway
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
?
-
induction with 3-methylcrotonoyl-CoA as growth substrate. No activity with 3-methylpentanoate as growth substrate
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
?
-
induction with 3-methylcrotonoyl-CoA as growth substrate. No activity with 3-methylpentanoate as growth substrate
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
r
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
the forward reaction is about 10times faster than the reverse reaction
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
a step in the metabolism of leucine into 3-methylcrotonyl CoA and related metabolites, overview
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
substrate of MCCase, EC 6.4.1.4, and GCCAse, EC 6.4.1.5
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
enzyme is involved in leucine catabolic pathway
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
?
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + 3-methylglutaconyl-CoA + phosphate
-
-
-
-
?
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + 3-methylglutaconyl-CoA + phosphate
-
-
-
-
?
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + 3-methylglutaconyl-CoA + phosphate
-
-
-
-
?
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + 3-methylglutaconyl-CoA + phosphate
-
-
-
-
?
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
r
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
key enzyme in the fermentation of glutamate to ammonia, carbon dioxide, hydrogen, acetate and butyrate
-
r
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
mitochondrial catabolism of leucine, also might function in the catabolism of isoprenoids and the mevalonate shunt
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
pivotal reaction required for both leucine catabolism and isoprenoid metabolism
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
in addition to leucine catabolism required for the operation of the mevalonate shunt
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
in addition to leucine catabolism required for the operation of the mevalonate shunt
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
catalyzes essential steps in the metabolism of amino acids
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
r
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
in addition to leucine catabolism required for the operation of the mevalonate shunt
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
in addition to leucine catabolism required for the operation of the mevalonate shunt
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
irreversible catabolic pathway of leucine
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
irreversible catabolic pathway of leucine
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
in addition to leucine catabolism required for the operation of the mevalonate shunt
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
in addition to leucine catabolism required for the operation of the mevalonate shunt
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
in addition to leucine catabolism required for the operation of the mevalonate shunt
-
ir
ATP + acetoacetyl-CoA + HCO3-
?
-
12% of the activity relative to 3-methylcrotonoyl-CoA
-
-
?
ATP + acetoacetyl-CoA + HCO3-
?
-
acetoacetyl-CoA inhibits, no activity as substrate
-
-
?
ATP + crotonoyl-CoA + HCO3-
?
-
(E)-crotonoyl-CoA
-
-
?
ATP + crotonoyl-CoA + HCO3-
?
-
27% of the activity relative to 3-methylcrotonoyl-CoA
-
-
?
ATP + crotonoyl-CoA + HCO3-
?
-
(E)-crotonoyl-CoA
-
-
?
ATP + crotonoyl-CoA + HCO3-
?
-
44% of the activity relative to 3-methylcrotonoyl-CoA
-
-
?
ATP + crotonoyl-CoA + HCO3-
?
-
-
-
-
?
ATP + crotonyl-CoA + HCO3-
ADP + phosphate + glutaconyl-CoA
-
much poorer substrate
-
ir
ATP + crotonyl-CoA + HCO3-
ADP + phosphate + glutaconyl-CoA
-
much poorer substrate
-
ir
ATP + crotonyl-CoA + HCO3-
ADP + phosphate + glutaconyl-CoA
-
much poorer substrate
-
ir
ATP + crotonyl-CoA + HCO3-
ADP + phosphate + glutaconyl-CoA
-
much poorer substrate
-
ir
ATP + crotonyl-CoA + HCO3-
ADP + phosphate + glutaconyl-CoA
-
much poorer substrate
-
ir
ATP + crotonyl-CoA + HCO3-
ADP + phosphate + glutaconyl-CoA
-
much poorer substrate
-
ir
additional information
?
-
-
catalyzes ATP/ADP exchange reaction
-
-
?
additional information
?
-
-
catalyzes ATP/diphosphate exchange reaction
-
-
?
additional information
?
-
-
acetoacetyl-CoA is no substrate
-
?
additional information
?
-
-
acetoacetyl-CoA is no substrate
-
?
additional information
?
-
-
IV-CoA and alpha-KIC are no substrates
-
?
additional information
?
-
-
children with 3-MCC deficiency show mental retardation or metabolic disturbances including ketoacidosis, hypoglycemia, or Reye syndrome, but 3-MCC deficiency can also occur in asymptomatic individuals or as non-specific fasting intolerance with normal neurological outcome, overview. The deficiency is diagnozed by 3-methylcrotonylglycine content in the urine
-
-
?
additional information
?
-
-
induced marginal biotin deficiency increases urinary excretion of 3-hydroxyisovaleric acid caused by decreased activity of the biotin-dependent enzyme beta-methylcrotonyl-CoA carboxylase, and decreased activity of the biotin-dependent enzyme propionyl-CoA carboxylase in peripheral blood lymphocytes, overview. Relation of biotin deficiency during pregnancy to teratogenesis, biotin deficiency does cause human birth defects, overview
-
-
?
additional information
?
-
-
acetoacetyl-CoA is no substrate
-
?
additional information
?
-
-
induced marginal biotin deficiency increases urinary excretion of 3-hydroxyisovaleric acid caused by decreased activity of the biotin-dependent enzyme beta-methylcrotonyl-CoA carboxylase, and decreased activity of the biotin-dependent enzyme propionyl-CoA carboxylase in peripheral blood lymphocytes, overview. Relation of biotin deficiency during pregnancy to teratogenesis, in mice a marginal degree of biotin deficiency in the dam causes a severe degree of deficiency in the fetus, overview
-
-
?
additional information
?
-
-
acetoacetyl-CoA is no substrate
-
?
additional information
?
-
-
geranyl-CoA carboxylase, GCCase, may substitute for MCCase in leucine catabolism, both the MCCase and GCCase enzymes play important roles in the leucine and acyclic terpene catabolic pathways, overview
-
-
?
additional information
?
-
-
MCCase shows no activity with geranyl-CoA, while the geranyl-CoA carboxylase, EC 6.4.1.5, is also active with 3-methylcrotonoyl-CoA in addition to the preferred substrate geranyl-CoA
-
-
?
additional information
?
-
-
acetoacetyl-CoA is no substrate
-
?
additional information
?
-
-
acetoacetyl-CoA is no substrate
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3-methylcrotonyl-CoA + ATP + HCO3-
3-methylglutaconyl-CoA + ADP + phosphate
-
mitochondrial leucine catabolic pathway
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + 3-methylglutaconyl-CoA + phosphate
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
r
additional information
?
-
ATP + 3-methylcrotonoyl-CoA + HCO3-
?
-
induction with 3-methylcrotonoyl-CoA as growth substrate. No activity with 3-methylpentanoate as growth substrate
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
?
-
enzyme of the leucine oxidative pathway
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
?
-
induction with 3-methylcrotonoyl-CoA as growth substrate. No activity with 3-methylpentanoate as growth substrate
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
?
-
induction with 3-methylcrotonoyl-CoA as growth substrate. No activity with 3-methylpentanoate as growth substrate
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
a step in the metabolism of leucine into 3-methylcrotonyl CoA and related metabolites, overview
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
-
?
ATP + 3-methylcrotonoyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
enzyme is involved in leucine catabolic pathway
-
-
?
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + 3-methylglutaconyl-CoA + phosphate
-
-
-
-
?
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + 3-methylglutaconyl-CoA + phosphate
-
-
-
-
?
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + 3-methylglutaconyl-CoA + phosphate
-
-
-
-
?
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + 3-methylglutaconyl-CoA + phosphate
-
-
-
-
?
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
key enzyme in the fermentation of glutamate to ammonia, carbon dioxide, hydrogen, acetate and butyrate
-
r
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
-
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
mitochondrial catabolism of leucine, also might function in the catabolism of isoprenoids and the mevalonate shunt
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
pivotal reaction required for both leucine catabolism and isoprenoid metabolism
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
in addition to leucine catabolism required for the operation of the mevalonate shunt
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
in addition to leucine catabolism required for the operation of the mevalonate shunt
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
catalyzes essential steps in the metabolism of amino acids
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
in addition to leucine catabolism required for the operation of the mevalonate shunt
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
in addition to leucine catabolism required for the operation of the mevalonate shunt
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
irreversible catabolic pathway of leucine
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
irreversible catabolic pathway of leucine
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
in addition to leucine catabolism required for the operation of the mevalonate shunt
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
in addition to leucine catabolism required for the operation of the mevalonate shunt
-
ir
ATP + 3-methylcrotonyl-CoA + HCO3-
ADP + phosphate + 3-methylglutaconyl-CoA
-
in addition to leucine catabolism required for the operation of the mevalonate shunt
-
ir
additional information
?
-
-
children with 3-MCC deficiency show mental retardation or metabolic disturbances including ketoacidosis, hypoglycemia, or Reye syndrome, but 3-MCC deficiency can also occur in asymptomatic individuals or as non-specific fasting intolerance with normal neurological outcome, overview. The deficiency is diagnozed by 3-methylcrotonylglycine content in the urine
-
-
?
additional information
?
-
-
induced marginal biotin deficiency increases urinary excretion of 3-hydroxyisovaleric acid caused by decreased activity of the biotin-dependent enzyme beta-methylcrotonyl-CoA carboxylase, and decreased activity of the biotin-dependent enzyme propionyl-CoA carboxylase in peripheral blood lymphocytes, overview. Relation of biotin deficiency during pregnancy to teratogenesis, biotin deficiency does cause human birth defects, overview
-
-
?
additional information
?
-
-
induced marginal biotin deficiency increases urinary excretion of 3-hydroxyisovaleric acid caused by decreased activity of the biotin-dependent enzyme beta-methylcrotonyl-CoA carboxylase, and decreased activity of the biotin-dependent enzyme propionyl-CoA carboxylase in peripheral blood lymphocytes, overview. Relation of biotin deficiency during pregnancy to teratogenesis, in mice a marginal degree of biotin deficiency in the dam causes a severe degree of deficiency in the fetus, overview
-
-
?
additional information
?
-
-
geranyl-CoA carboxylase, GCCase, may substitute for MCCase in leucine catabolism, both the MCCase and GCCase enzymes play important roles in the leucine and acyclic terpene catabolic pathways, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Li+
-
relative activation by monovalent cations in decreasing order: K+/ NH4+, Na+, Li+
Na+
-
relative activation by monovalent cations in decreasing order: K+/ NH4+, Na+, Li+
Co2+
-
divalent cation required, Co2+ activates at 34% of the efficiency relative to Mg2+
Co2+
-
requirement for free Mg2+ ions can be partially replaced by Mn2+ or Co2+, but not by Zn2+
Co2+
-
requirement for free Mg2+ ions can be partially replaced by Mn2+ or Co2+, but not by Zn2+
Co2+
-
requirement for free Mg2+ ions can be partially replaced by Mn2+ or Co2+, but not by Zn2+
Co2+
-
requirement for free Mg2+ ions can be partially replaced by Mn2+ or Co2+, but not by Zn2+
Co2+
-
requirement for free Mg2+ ions can be partially replaced by Mn2+ or Co2+, but not by Zn2+
Co2+
-
activates with 57% of the efficiency relative to Mg2+
Co2+
-
requirement for free Mg2+ ions can be partially replaced by Mn2+ or Co2+, but not by Zn2+
Cs+
-
activator
Cs+
-
monovalent cations activate, K+, Cs+, Rb+ or NH4+
K+
-
activates 7fold at 50 mM. Relative activation by monovalent cations in decreasing order: K+/ NH4+, Na+, Li+
K+
-
activated 4 to 5fold by K+ or NH4+, 50-100 mM, kidney enzyme
K+
-
1.1 to 1.2fold stimulation in presence of 20 mM KCl. Inhibition at concentrations higher than 50 mM
K+
-
1.1 to 1.2fold stimulation in presence of 20 mM KCl. Inhibition at concentrations higher than 50 mM
K+
-
monovalent cations activate, K+, Cs+, Rb+ or NH4+
Mg2+
-
Mg2+ or Mn2+ required
Mg2+
-
divalent cation required, Mg2+ is the best activator
Mg2+
-
requires free Mg2+ ions for activation, in excess of thatrequired to complex ATP
Mg2+
-
Mg-ATP-dependent carboxylation
Mg2+
-
requires free Mg2+ ions for activation, in excess of thatrequired to complex ATP
Mg2+
-
carboxylation of methylcrotonyl-CoA is Mg2+-dependent
Mg2+
-
requires free Mg2+ ions for activation, in excess of thatrequired to complex ATP
Mg2+
-
divalent metal ion required, maximal activity at 6 mM Mg2+
Mg2+
-
maximal activation at 2.5 mM Mg2+ in presence of 1 mM ATP
Mg2+
-
requires free Mg2+ ions for activation, in excess of thatrequired to complex ATP
Mg2+
-
maximal activation at 3 mM Mg2+ in presence of 1 mM ATP
Mg2+
-
requires free Mg2+ ions for activation, in excess of thatrequired to complex ATP
Mg2+
-
maximal activity at 2 mM Mg2+, at ATP concentrations 0.025 mM, 0.05 mM or 1 mM
Mg2+
-
divalent cation required, Mg2+ is the best activator
Mg2+
-
requires free Mg2+ ions for activation, in excess of thatrequired to complex ATP
Mn2+
-
Mn2+ or Mg2+ required
Mn2+
-
divalent cation required. Mn2+ activates with 85% of the efficiency relative to Mg2+
Mn2+
-
requirement for free Mg2+ ions can be partially replaced by Mn2+ or Co2+, but not by Zn2+
Mn2+
-
requirement for free Mg2+ ions can be partially replaced by Mn2+ or Co2+, but not by Zn2+
Mn2+
-
requirement for free Mg2+ ions can be partially replaced by Mn2+ or Co2+, but not by Zn2+
Mn2+
-
requirement for free Mg2+ ions can be partially replaced by Mn2+ or Co2+, but not by Zn2+
Mn2+
-
requirement for free Mg2+ ions can be partially replaced by Mn2+ or Co2+, but not by Zn2+
Mn2+
-
activates with 77% of the efficiency relative to Mg2+
Mn2+
-
requirement for free Mg2+ ions can be partially replaced by Mn2+ or Co2+, but not by Zn2+
NH4+
-
activated 4 to 5fold by K+ or NH4+, 50-100 mM, kidney enzyme
NH4+
-
relative activation by monovalent cations in decreasing order: K+/ NH4+, Na+, Li+
NH4+
-
monovalent cations activate, K+, Cs+, Rb+ or NH4+
Rb+
-
activator
Rb+
-
monovalent cations activate, K+, Cs+, Rb+ or NH4+. Maximal activity obtained with Rb+
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11624
-
1 * 65000 + 1 * 36000 + 1 * 25000 + 1 * 14000, alpha GcdA, beta GcdB, gamma GcdC, delta GcdD, SDS-PAGE, 1 * 64300 + 1 * 38902 + 1 * 14133 + 1 * 11624, alpha GcdA, beta GcdB, gamma GcdC, delta GcdD, amino acid sequence
14000
-
1 * 65000 + 1 * 36000 + 1 * 25000 + 1 * 14000, alpha GcdA, beta GcdB, gamma GcdC, delta GcdD, SDS-PAGE, 1 * 64300 + 1 * 38902 + 1 * 14133 + 1 * 11624, alpha GcdA, beta GcdB, gamma GcdC, delta GcdD, amino acid sequence
14133
-
1 * 65000 + 1 * 36000 + 1 * 25000 + 1 * 14000, alpha GcdA, beta GcdB, gamma GcdC, delta GcdD, SDS-PAGE, 1 * 64300 + 1 * 38902 + 1 * 14133 + 1 * 11624, alpha GcdA, beta GcdB, gamma GcdC, delta GcdD, amino acid sequence
25000
-
1 * 65000 + 1 * 36000 + 1 * 25000 + 1 * 14000, alpha GcdA, beta GcdB, gamma GcdC, delta GcdD, SDS-PAGE, 1 * 64300 + 1 * 38902 + 1 * 14133 + 1 * 11624, alpha GcdA, beta GcdB, gamma GcdC, delta GcdD, amino acid sequence
36000
-
1 * 65000 + 1 * 36000 + 1 * 25000 + 1 * 14000, alpha GcdA, beta GcdB, gamma GcdC, delta GcdD, SDS-PAGE, 1 * 64300 + 1 * 38902 + 1 * 14133 + 1 * 11624, alpha GcdA, beta GcdB, gamma GcdC, delta GcdD, amino acid sequence
38902
-
1 * 65000 + 1 * 36000 + 1 * 25000 + 1 * 14000, alpha GcdA, beta GcdB, gamma GcdC, delta GcdD, SDS-PAGE, 1 * 64300 + 1 * 38902 + 1 * 14133 + 1 * 11624, alpha GcdA, beta GcdB, gamma GcdC, delta GcdD, amino acid sequence
520000 - 580000
-
gel filtration
53000
-
4 * 74000, biotin-containing subunit, + 4 * 53000, biotin-free subunit, SDS-PAGE
54000
-
4 * 76000, biotin-containing subunit, + 4 * 54000, biotin-free subunit, SDS-PAGE
58500
-
6 * 58500 + 6 * 80000, SDS-PAGE
61000
-
x * 61000, biotin-free subunit A, + x * 73500, biotin-containing subunit B
62000
-
x * 62000, biotin-free subunit, + x * 80000, biotin-containing subunit, SDS-PAGE
64300
-
1 * 65000 + 1 * 36000 + 1 * 25000 + 1 * 14000, alpha GcdA, beta GcdB, gamma GcdC, delta GcdD, SDS-PAGE, 1 * 64300 + 1 * 38902 + 1 * 14133 + 1 * 11624, alpha GcdA, beta GcdB, gamma GcdC, delta GcdD, amino acid sequence
65000
-
1 * 65000 + 1 * 36000 + 1 * 25000 + 1 * 14000, alpha GcdA, beta GcdB, gamma GcdC, delta GcdD, SDS-PAGE, 1 * 64300 + 1 * 38902 + 1 * 14133 + 1 * 11624, alpha GcdA, beta GcdB, gamma GcdC, delta GcdD, amino acid sequence
72000
-
1 * 60000 + 1 * 72000, SDS-PAGE, Western Blot
73500
-
x * 61000, biotin-free subunit A, + x * 73500, biotin-containing subunit B
760000
-
analytical ultracentrifugation
900000
nondenaturing PAGE, gel filtration
500000
-
gel filtration
60000
-
1 * 60000 + 1 * 72000, SDS-PAGE, Western Blot
60000
-
1 * 60000 + 1 * 85000
60000
-
4 * 80000 + 4 * 60000, SDS-PAGE
60000
-
4 * 80000 + 4 * 60000, SDS-PAGE
60000
-
6 * 800000 + 6 * 60000
60000
-
6 * 800000 + 6 * 60000
60000
-
6 * 800000 + 6 * 60000
60000
-
6 * 800000 + 6 * 60000
60000
x * 85000 + x * 60000, heteromeric enzyme composed of biotin-containing MCC-A and non-biotin-containing MCC-B subunits
60000
-
x * 60000 + 6 * 80000, 3-methylcrotonyl-CoA carboxylase is a heteromultimeric complex (MW: 500000 Da-800000 Da) that is composed of alpha and beta subunits (ratio 1:1) which are encoded by distinct genes. MCCCalpha is the larger subunit that has 725 amino acids, which contains the Met-Lys-Met biotin attachment domain near its COOH end. Human MCCCbeta is the small subunit that is composed of 563 amino acids, which functions as a carboxyltransferase, SDS-PAGE
63000
-
x * 63000 + x * 73000, SDS-PAGE
63000
-
4 * 63000, biotin-free subunit A, + x * 73000, biotin-containing subunit B
73000
-
x * 63000 + x * 73000, SDS-PAGE
73000
-
4 * 63000, biotin-free subunit A, + x * 73000, biotin-containing subunit B
74000
-
4 * 74000, biotin-containing subunit, + 4 * 53000, biotin-free subunit, SDS-PAGE
74000
-
x * 74000, SDS-PAGE
76000
-
4 * 76000, biotin-containing subunit, + 4 * 54000, biotin-free subunit, SDS-PAGE
78000
-
x * 78000, biotin-free subunit A, + x * 96000, biotin-containing subunit, SDS-PAGE
78000
-
4 * 78000, biotin-free subunit A, + 4 * 96000, biotin-containing subunit B
80000
-
x * 62000, biotin-free subunit, + x * 80000, biotin-containing subunit, SDS-PAGE
80000
-
6 * 58500 + 6 * 80000, SDS-PAGE
80000
-
4 * 80000 + 4 * 60000, SDS-PAGE
80000
-
4 * 80000 + 4 * 60000, SDS-PAGE
80000
-
x * 60000 + 6 * 80000, 3-methylcrotonyl-CoA carboxylase is a heteromultimeric complex (MW: 500000 Da-800000 Da) that is composed of alpha and beta subunits (ratio 1:1) which are encoded by distinct genes. MCCCalpha is the larger subunit that has 725 amino acids, which contains the Met-Lys-Met biotin attachment domain near its COOH end. Human MCCCbeta is the small subunit that is composed of 563 amino acids, which functions as a carboxyltransferase, SDS-PAGE
800000
-
6 * 800000 + 6 * 60000
800000
-
6 * 800000 + 6 * 60000
800000
-
6 * 800000 + 6 * 60000
800000
-
6 * 800000 + 6 * 60000
800000 - 900000
-
nondenaturing PAGE
800000 - 900000
-
nondenaturing PAGE
800000 - 900000
-
nondenaturing PAGE
800000 - 900000
-
nondenaturing PAGE
835000
-
PAGE, gel filtration
835000
-
PAGE, gel filtration
85000
-
1 * 60000 + 1 * 85000
85000
x * 85000 + x * 60000, heteromeric enzyme composed of biotin-containing MCC-A and non-biotin-containing MCC-B subunits
96000
-
x * 78000, biotin-free subunit A, + x * 96000, biotin-containing subunit, SDS-PAGE
96000
-
4 * 78000, biotin-free subunit A, + 4 * 96000, biotin-containing subunit B
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Homo sapiens
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3-Methylcrotonyl-CoA and geranyl-CoA carboxylases from Pseudomonas citronellolis
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Homo sapiens
-
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-
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Arabidopsis thaliana
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Rattus norvegicus, Rattus norvegicus Wistar
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-
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Arabidopsis thaliana (Q42523)
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Homo sapiens
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Homo sapiens
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Pagrus major
-
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53
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Homo sapiens
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Phaeodactylum tricornutum
brenda