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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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ATP + acetyl-CoA + HCO3-
?
n-butyryl-CoA (0.5 mM) is carboxylated at 4.6% compared to carboxylation of acetyl-CoA or propionyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
ATP + butanoyl-CoA + HCO3-
ADP + phosphate + ?
ATP + butyryl-CoA + HCO3-
ADP + phosphate + ?
ATP + crotonyl-CoA + HCO3-
ADP + phosphate + ?
-
at 3% the velocity compared to propanoyl-CoA
-
-
?
ATP + propanoyl-CoA + HCO3-
?
-
key enzyme of the 3-hydroxypropanoate cycle
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (2S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
ATP + propionyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
preferred substrate
-
-
?
ATP + succinyl-CoA + HCO3-
ADP + phosphate + ?
-
-
-
?
butyryl-CoA + CO2
?
-
-
-
?
GTP + propanoyl-CoA + HCO3-
GDP + phosphate + (S)-methylmalonyl-CoA
propionyl-CoA + CO2
(2S)-methylmalonyl-CoA
propionyl-CoA + CO2
(S)-methylmalonyl-CoA
UTP + propanoyl-CoA + HCO3-
UDP + phosphate + (S)-methylmalonyl-CoA
additional information
?
-
acetyl-CoA + CO2
?
the enzyme has a preference for propionyl-CoA over acetyl-CoA as the substrate
-
-
?
acetyl-CoA + CO2
?
the wild type enzyme shows no activity with acetyl-CoA, but mutant enzyme D422I does
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
EC 6.4.1.2 activity
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
EC 6.4.1.2 activity
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
at a rate 1.5% that obtained for propionyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
EC 6.4.1.2 activity
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
EC 6.4.1.2 activity
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no other acetyl-CoA carboxylase detected in this organism
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
EC 6.4.1.2 activity
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
the enzyme has a preference for propanoyl-CoA over acetyl-CoA as the substrate
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
EC 6.4.1.2 activity
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
at 0.7% of the velocity compared to propanoyl-CoA
-
-
?
ATP + butanoyl-CoA + HCO3-
ADP + phosphate + ?
-
-
-
-
?
ATP + butanoyl-CoA + HCO3-
ADP + phosphate + ?
-
at 5.7% of the velocity compared to propanoyl-CoA
-
-
?
ATP + butyryl-CoA + HCO3-
ADP + phosphate + ?
-
-
-
?
ATP + butyryl-CoA + HCO3-
ADP + phosphate + ?
-
-
-
-
?
ATP + butyryl-CoA + HCO3-
ADP + phosphate + ?
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
the bifunctional enzyme also catalyzes the carboxylation of acetyl-CoA. Vmax/Km for carboxylation of propanoyl-CoA is 1.6fold higher than Vmax/Km for carboxylation of acetyl-CoA. Quite specific for ATP. No activity with ADP, AMP, GTP, CTP, UTP, or dTTP (0.2 mM)
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for odd-chain fatty acids and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for odd-chain fatty acids and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for odd-chain fatty acids, cholesterol and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for odd-chain fatty acids, cholesterol and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
key enzyme in catabolic pathways for odd-chain fatty acids, cholesterol and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
key enzyme in catabolic pathways for odd-chain fatty acids and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for long-chain fatty acids, polyketides and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for odd-chain fatty acids and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
the enzyme has a preference for propanoyl-CoA over acetyl-CoA as the substrate
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
important for polyketide and fatty acid synthesis
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
Sulfuracidifex metallicus Kra23 / DSM 6482
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
Sulfuracidifex metallicus Kra23 / DSM 6482
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
GTP + propanoyl-CoA + HCO3-
GDP + phosphate + (S)-methylmalonyl-CoA
-
10% of the activity with ATP
-
?
GTP + propanoyl-CoA + HCO3-
GDP + phosphate + (S)-methylmalonyl-CoA
-
10% of the activity with ATP
-
?
propionyl-CoA + CO2
(2S)-methylmalonyl-CoA
-
-
-
-
?
propionyl-CoA + CO2
(2S)-methylmalonyl-CoA
-
-
-
-
?
propionyl-CoA + CO2
(2S)-methylmalonyl-CoA
-
-
-
-
?
propionyl-CoA + CO2
(2S)-methylmalonyl-CoA
-
-
-
-
?
propionyl-CoA + CO2
(S)-methylmalonyl-CoA
the enzyme has a preference for propionyl-CoA over acetyl-CoA as the substrate
-
-
?
propionyl-CoA + CO2
(S)-methylmalonyl-CoA
-
-
-
?
propionyl-CoA + CO2
(S)-methylmalonyl-CoA
-
-
-
-
?
UTP + propanoyl-CoA + HCO3-
UDP + phosphate + (S)-methylmalonyl-CoA
-
40% of the activity with ATP
-
?
UTP + propanoyl-CoA + HCO3-
UDP + phosphate + (S)-methylmalonyl-CoA
-
40% of the activity with ATP
-
?
additional information
?
-
neither succinyl-CoA, palmitoyl-CoA, acetate (plus 0.5 mM CoASH), propionate (plus 0.5 mM CoASH), nor pyruvate is carboxylated by the enzyme
-
-
?
additional information
?
-
-
neither succinyl-CoA, palmitoyl-CoA, acetate (plus 0.5 mM CoASH), propionate (plus 0.5 mM CoASH), nor pyruvate is carboxylated by the enzyme
-
-
?
additional information
?
-
-
enzyme may play an important role in the biosynthesis of rifamycin as well as in the degradation of various amino acids
-
-
?
additional information
?
-
-
inherited deficiency of the enzyme activity leads to propionicacidemia
-
-
?
additional information
?
-
-
inherited deficiency of the enzyme activity leads to propionicacidemia
-
-
?
additional information
?
-
-
methylmalonyl-CoA, malonyl-CoA, isobutyryl-CoA, and isovaleryl-CoA are not metabolized
-
?
additional information
?
-
-
required for development of Myxococcus xanthus. The dcm-1 mutant, which is deficient in propanoyl-CoA carboxylase is unable to form fruiting bodies and spores
-
-
?
additional information
?
-
the wild type enzyme shows no activity with acetyl-CoA
-
-
?
additional information
?
-
-
the wild type enzyme shows no activity with acetyl-CoA
-
-
?
additional information
?
-
-
acetyl-CoA is not well converted to malonyl-CoA
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + propanoyl-CoA + HCO3-
?
-
key enzyme of the 3-hydroxypropanoate cycle
-
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
additional information
?
-
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for odd-chain fatty acids and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for odd-chain fatty acids and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for odd-chain fatty acids, cholesterol and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for odd-chain fatty acids, cholesterol and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
key enzyme in catabolic pathways for odd-chain fatty acids, cholesterol and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
key enzyme in catabolic pathways for odd-chain fatty acids and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for long-chain fatty acids, polyketides and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
key enzyme in catabolic pathways for odd-chain fatty acids and branched chain amino acids
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
important for polyketide and fatty acid synthesis
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, 3 -hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
Sulfuracidifex metallicus Kra23 / DSM 6482
-
CO2 fixation during autotrophic growth, enzyme of the 3-hydroxypropionate cycle
-
?
additional information
?
-
-
enzyme may play an important role in the biosynthesis of rifamycin as well as in the degradation of various amino acids
-
-
?
additional information
?
-
-
inherited deficiency of the enzyme activity leads to propionicacidemia
-
-
?
additional information
?
-
-
inherited deficiency of the enzyme activity leads to propionicacidemia
-
-
?
additional information
?
-
-
required for development of Myxococcus xanthus. The dcm-1 mutant, which is deficient in propanoyl-CoA carboxylase is unable to form fruiting bodies and spores
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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A487V
-
no effect on activity
D178H
increased alpha/beta subunit ratio, very low activity
DELTA408
catalytically inactive
G246V
-
activity of the mutant enzyme is 12% of the wild-type activity
M442T
catalytically inactive
P228L
increased alpha/beta subunit ratio, very low activity
R165Q
-
beta subunit, no effect on subunit interactions and activity
R44P
catalytically inactive
R67S
-
beta subunit, no effect on subunit interactions only when expressed at low temperature (27°C), reduced activity at 37°C
W531X
-
activity of the mutant enzyme is less than 1% of the wild-type activity
A431C
-
kcat (propionyl-CoA) decreased compared to wild-type, Km (propionyl-CoA) increased compared to wild-type. kcat (acetyl-CoA) increased compared to wild-type, Km (propionyl-CoA) similar to wild-type
A431D
-
mutant enzyme shows no activity
A431I
-
kcat (propionyl-CoA) decreased compared to wild-type, Km (propionyl-CoA) increased compared to wild-type. kcat (acetyl-CoA) increased compared to wild-type, Km (propionyl-CoA) similar to wild-type
A431L
-
mutant enzyme shows no activity
Y430H/A431I
-
mutant enzyme shows no activity
D440I
the mutation does not change the substrate preference of the enzyme
G668R
the mutation in the biotin carboxyl carrier protein domain abolishes biotinylation
R165Q
the mutation disturbs the recognition of the adenine base of CoA
R165W
the mutation disturbs the recognition of the adenine base of CoA
R399Q
the mutation leads to a large loss in activity
D422A
mutant of the PccB subunit, shows strong preference for butyryl-CoA as substrate
D422C
mutant of the PccB subunit, shows strong preference for butyryl-CoA as substrate
D422I
mutant of the PccB subunit, accepts acetyl-CoA, propionyl-CoA, and butyrl-CoA as substrates, the latter two with lower Vmax/Km values as compared to the wild type enzyme
D422L
mutant of the PccB subunit, the mutants has narrowed down their substrate specificity, accepting only propionyl-CoA as its substrate
D422N
mutant of the PccB subunit, the mutants has narrowed down their substrate specificity, accepting only propionyl-CoA as its substrate
D422V
mutant of the PccB subunit, accepts both propionyl-CoA and butyrl-CoA as substrates but with lower Vmax/Km values as compared to the wild type enzyme
A497V
-
beta subunit, no effect on subunit interactions and activity
A497V
significantly increased activity
A497V
-
polymorphism, 30% higher specific activity than wild-type enzyme
A513_R514insP
-
insertion between residues 513 and 514 of the beta subunit, leads to partial degradation of the subunit, strongly reduced activity
A513_R514insP
insertion, severe degradation of the subunit
DELTA499
-
beta subunit, leads to partial degradation of the subunit, strongly reduced activity
DELTA499
severe degradation of the subunit
DELTA514
-
beta subunit, leads to partial degradation of the subunit, strongly reduced activity
DELTA514
severe degradation of the subunit
DELTA531
-
very low activity
DELTA531
-
beta subunit, no effect
DELTA531
-
beta subunit, strongly affects subunit interactions, very low activity
E168K
-
beta subunit, no effect on subunit interactions only when expressed at low temperature (27°C), reduced activity at 37°C
E168K
increased alpha/beta subunit ratio, very low activity
E168K
-
mutant enzyme shows 32.3% of the specific activity of purified wild-type enzyme
G131R
catalytically inactive
G131R
-
beta subunit, no effect on subunit interactions only when expressed at low temperature (27°C), reduced activity at 37°C
G198D
catalytically inactive
G198D
-
beta subunit, no effect on subunit interactions only when expressed at low temperature (27°C) reduced activity at 37°C
L519P
-
very low activity
L519P
-
beta subunit, leads to complete degradation of the subunit, no activity
L519P
-
beta subunit, strongly affects subunit interactions, very low activity
L519P
complete degradation of the subunit
L519P
-
activity of the mutant enzyme is less than 1% of the wild-type activity
N536D
-
beta subunit, leads to complete degradation of the subunit, no activity
N536D
-
beta subunit, strongly affects subunit interactions, very low activity
N536D
complete degradation of the subunit
R165W
-
beta subunit, no effect on subunit interactions only when expressed at low temperature (27°C), reduced activity at 37°C
R165W
increased alpha/beta subunit ratio, very low activity
R165W
-
activity of the mutant enzyme is less than 1% of the wild-type activity
R165W
-
mutant enzyme shows 42.5% of the specific activity of purified wild-type enzyme
R410W
very low activity
R410W
-
activity of the mutant enzyme is 9% of the wild-type activity
R410W
-
mutant enzyme shows 42.61% of the specific activity of purified wild-type enzyme
R512C
-
very low activity
R512C
-
beta subunit, leads to partial degradation of the subunit, strongly reduced activity
R512C
-
beta subunit, strongly affects subunit interactions, very low activity
R512C
severe degradation of the subunit
R512C
-
activity of the mutant enzyme is less than 1% of the wild-type activity
S106R
catalytically inactive
S106R
-
beta subunit, no effect on subunit interactions only when expressed at low temperature (27°C), reduced activity at 37°C
V205D
catalytically inactive
V205D
increased alpha/beta subunit ratio
V205D
-
activity of the mutant enzyme is less than 1% of the wild-type activity
additional information
-
intragenic complementation analysis to 15 naturally occuring mutations in the PCCB gene
additional information
-
stringent model of propionyl CoA carboxylase subunit A deficiency, where homozygous knock-out mice are born, but die within 36 hours. Injection of vectors expressing propionyl CoA carboxylase subunit A significantly increases the lifespan for both unmodified and polyethylene glycol modified vectors, but the rescue is transient
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Streptomyces coelicolor
-
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Measuring propionyl-CoA carboxylase activity in phytohemagglutinin stimulated lymphocytes using high performance liquid chromatography
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