Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
adenosylcobyrinic acid a,c-diamide + ATP + L-glutamine + H2O
adenosylcobyric acid + ADP + phosphate + L-glutamate
ATP + adenosylcobyrinic acid a,c-diamide + ammonia + H2O
ADP + phosphate + adenosylcobyric acid + ?
-
ammonia can replace L-glutamine as amide group donor, but L-glutamine is preferred
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
ATP + adenosylcobyrinic acid diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
four carboxylates attached to the corrinoid ring are amidated in a dissociative fashion. The four carboxylates are amidated in a sequence beginning with carboxylate e and followed in turn by carboxylates d, b, and g
-
-
?
ATP + adenosylcobyrinic acid pentaamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
ATP + adenosylcobyrinic acid tetraamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
ATP + adenosylcobyrinic acid triamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
cobinic acid a,c-diamide + ATP + L-glutamine + H2O
cobinamide + ADP + phosphate + L-glutamate
additional information
?
-
adenosylcobyrinic acid a,c-diamide + ATP + L-glutamine + H2O
adenosylcobyric acid + ADP + phosphate + L-glutamate
-
-
-
?
adenosylcobyrinic acid a,c-diamide + ATP + L-glutamine + H2O
adenosylcobyric acid + ADP + phosphate + L-glutamate
-
vitamin B12 biosynthesis
-
?
adenosylcobyrinic acid a,c-diamide + ATP + L-glutamine + H2O
adenosylcobyric acid + ADP + phosphate + L-glutamate
-
-
-
?
adenosylcobyrinic acid a,c-diamide + ATP + L-glutamine + H2O
adenosylcobyric acid + ADP + phosphate + L-glutamate
-
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
-
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
cobinamide biosynthesis
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
-
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
cobinamide biosynthesis
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
-
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
biosynthesis of vitamin B12, cobalamin biosynthetic pathway
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
cobalamin biosynthetic pathway, involved in coenzyme B12 synthesis
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
CobQ is involved in the biosynthesis of adenosylcobalamin, i.e. vitamin B12, aerobic pathway
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
involved in cobalamin biosynthesis
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
CobQ amidates the side chains b, d, e, and g generating adenosylcobyric acid, requires glutamine as the amide donor
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
CobQ catalyzes amidations at positions b, d, e and g
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
CobQ contains an unusual Triad family, class I, glutamine amidotransferase domain with conserved Cys and His residues, but lacking the Glu residue of the catalytic triad, domain organization, model of substrate binding, catalytic mechanism, CobQ catalyzes amidation of the carboxyls b, d, e, and g in a strict order, one ATP molecule and one glutamine molecule are consumed for each amidation reaction
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
enzyme catalyzes the stepwise amidation of carboxyl groups b, d, e, and g of cobyrinic acid a,c-diamide, four-step amidation sequence from cobyrinic acid a,c-diamide to cobyric acid via the formation of corbyrinic acid triamide, tetraamide, and pentaamide intermediates, the amidations are carried out in a specific order, enzyme is specific to coenzyme forms of substrates, no amidation of the carboxyl group at position f, L-glutamine is the preferred amide group donor
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
cobalamin biosynthetic pathway, involved in coenzyme B12 synthesis
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
CobQ catalyzes amidations at positions b, d, e and g
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
biosynthesis of vitamin B12, cobalamin biosynthetic pathway
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
enzyme catalyzes the stepwise amidation of carboxyl groups b, d, e, and g of cobyrinic acid a,c-diamide, four-step amidation sequence from cobyrinic acid a,c-diamide to cobyric acid via the formation of corbyrinic acid triamide, tetraamide, and pentaamide intermediates, the amidations are carried out in a specific order, enzyme is specific to coenzyme forms of substrates, no amidation of the carboxyl group at position f, L-glutamine is the preferred amide group donor
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
-
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
CbiP is involved in the biosynthesis of adenosylcobalamin, i.e. vitamin B12, anaerobic pathway
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
involved in the de novo cobinamide biosynthesis pathway
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
CbiP catalyzes b, d, e, and g amidation
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
-
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
involved in the de novo cobinamide biosynthesis pathway
-
-
?
ATP + adenosylcobyrinic acid pentaamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
-
-
-
?
ATP + adenosylcobyrinic acid pentaamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
four carboxylates attached to the corrinoid ring are amidated in a dissociative fashion. The four carboxylates are amidated in a sequence beginning with carboxylate e and followed in turn by carboxylates d, b, and g
-
-
?
ATP + adenosylcobyrinic acid tetraamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
two-step amidation
-
-
?
ATP + adenosylcobyrinic acid tetraamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
four carboxylates attached to the corrinoid ring are amidated in a dissociative fashion. The four carboxylates are amidated in a sequence beginning with carboxylate e and followed in turn by carboxylates d, b, and g
-
-
?
ATP + adenosylcobyrinic acid triamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
three-step amidation
-
-
?
ATP + adenosylcobyrinic acid triamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
four carboxylates attached to the corrinoid ring are amidated in a dissociative fashion. The four carboxylates are amidated in a sequence beginning with carboxylate e and followed in turn by carboxylates d, b, and g
-
-
?
cobinic acid a,c-diamide + ATP + L-glutamine + H2O
cobinamide + ADP + phosphate + L-glutamate
-
-
-
?
cobinic acid a,c-diamide + ATP + L-glutamine + H2O
cobinamide + ADP + phosphate + L-glutamate
-
-
-
?
additional information
?
-
-
no amidation of adenosylcobyric acid, hydrogenobyrinic acid a,c-diamide, monocyano or diaqua form of cobyrinic acid a,c-diamide
-
-
?
additional information
?
-
-
no amidation of adenosylcobyric acid, hydrogenobyrinic acid a,c-diamide, monocyano or diaqua form of cobyrinic acid a,c-diamide
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
adenosylcobyrinic acid a,c-diamide + ATP + L-glutamine + H2O
adenosylcobyric acid + ADP + phosphate + L-glutamate
-
vitamin B12 biosynthesis
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
cobinamide biosynthesis
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
cobinamide biosynthesis
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
-
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
biosynthesis of vitamin B12, cobalamin biosynthetic pathway
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
cobalamin biosynthetic pathway, involved in coenzyme B12 synthesis
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
CobQ is involved in the biosynthesis of adenosylcobalamin, i.e. vitamin B12, aerobic pathway
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
involved in cobalamin biosynthesis
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
cobalamin biosynthetic pathway, involved in coenzyme B12 synthesis
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
biosynthesis of vitamin B12, cobalamin biosynthetic pathway
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
CbiP is involved in the biosynthesis of adenosylcobalamin, i.e. vitamin B12, anaerobic pathway
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
involved in the de novo cobinamide biosynthesis pathway
-
-
?
ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O
ADP + phosphate + adenosylcobyric acid + L-glutamate
-
involved in the de novo cobinamide biosynthesis pathway
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Crouzet, J.; Levy-Schil, S.; Cameron, B.; Cauchois, L.; Rigault, S.; Rouyez, M.C.; Blanche, F.; Debussche, L.; Thibaut, D.
Nucleotide sequence and genetic analysis of a 13.1-kilobase-pair Pseudomonas denitrificans DNA fragment containing five cob genes and identification of structural genes encoding Cob(I)alamin adenosyltransferase, cobyric acid synthase, and bifunctional cobinamide kinase-cobinamide phosphate guanylyltransferase
J. Bacteriol.
173
6074-6087
1991
Pseudomonas denitrificans (nom. rej.) (P29932), Pseudomonas denitrificans (nom. rej.), Pseudomonas denitrificans (nom. rej.) SC510 Rifr(pXL617) (P29932)
brenda
Warren, M.J.; Raux, E.; Schubert, H.L.; Escalante-Semerena, J.C.
The biosynthesis of adenosylcobalamin (vitamin B12)
Nat. Prod. Rep.
19
390-412
2002
Salmonella enterica, Pseudomonas denitrificans (nom. rej.)
brenda
Blanche F.; Maton, L.; Debussche, L.; Thibaut, D.
Purification and characterization of cob(II)yrinic acid a,c-diamide reductase from Pseudomonas denitrificans
J. Bacteriol.
174
7452-7454
1992
Pseudomonas denitrificans (nom. rej.)
brenda
Blanche, F.; Couder, M.; Debussche, L.; Thibaut, D.; Cameron, B.; Cruzet, J.
Biosynthesis of vitamin B12: stepwise amidation of carboxyl groups b, d, e, and g of cobyrinic acid a,c-diamide is catalyzed by one enzyme in Pseudomonas denitrificans
J. Bacteriol.
173
6046-6051
1991
Pseudomonas denitrificans (nom. rej.)
brenda
Galperin, M.Y.; Grishin, N.V.
The synthetase domains of cobalamin biosynthesis amidotransferases cobB and cobQ belong to a new family of ATP-dependent amidoligases, related to dethiobiotin synthetase
Proteins
41
238-247
2000
Escherichia coli, Pseudomonas denitrificans (nom. rej.)
brenda
Woodson, J.D.; Zayas, C.L.; Escalante-Semerena, J.C.
A new pathway for salvaging the coenzyme B12 precursor cobinamide in archaea requires cobinamide-phosphate synthase (CbiB) enzyme activity
J. Bacteriol.
185
7193-7201
2003
Salmonella enterica, Halobacterium sp., Salmonella enterica TR6583
brenda
Williams, L.; Fresquet, V.; Santander, P.J.; Raushel, F.M.
The multiple amidation reactions catalyzed by cobyric acid synthetase from Salmonella typhimurium are sequential and dissociative
J. Am. Chem. Soc.
129
294-295
2007
Salmonella enterica subsp. enterica serovar Typhimurium
brenda