Reference on EC 6.3.2.6 - phosphoribosylaminoimidazolesuccinocarboxamide synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ebbole, D.J.; Zalkin, H.
Cloning and characterization of a 12-gene cluster from Bacillus subtilis encoding nine enzymes for de novo purine nucleotide synthesis
J. Biol. Chem.
262
8274-8287
1987
Bacillus subtilis
Parker, J.
Identification of the purC gene product of Escherichia coli
J. Bacteriol.
157
712-717
1984
Escherichia coli
Buchanan, J.M.; Lukens, L.N.; Miller, R.W.
N-(5-Amino-1-ribosyl-4-imidazolylcarbonyl)-L-aspartic acid 5-phosphate synthetase
Methods Enzymol.
51
186-193
1978
Gallus gallus
Hilton Patey, C.A.; Shaw, G.
Purification and properties of an enzyme duet, phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthetase, involved in the biosynthesis of purine nucleotides de novo
Biochem. J.
135
543-545
1973
Gallus gallus
Tiedeman, A.A.; DeMarini, D.J.; Parker, J.; Smith, J.M.
DNA sequence of the purC gene encoding 5-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide synthetase and organization of the dapA-purC region of Escherichia coli K-12
J. Bacteriol.
172
6035-6041
1990
Escherichia coli
Chen, Z.D.; Dixon, J.E.; Zalkin, H.
Cloning of a chicken liver cDNA encoding 5-aminoimidazole ribonucleotide carboxylase and 5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase by functional complementation of Escherichia coli pur mutants
Proc. Natl. Acad. Sci. USA
87
3097-3101
1990
Gallus gallus
Humble, R.W.; Mackenzie, G.; Shaw, G.
Rapid purification of a bifunctional protein complex possessing phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) and phosphoribosylaminoimidazolesuccinocarboxamide synthetase
Adv. Exp. Med. Biol.
309B
223-227
1991
Ovis aries
Grebenko, A.I.; Levdikov, V.M.; Barynin, V.V.; Melik-Adamyan, W.R.
Crystallization and preliminary X-ray investigation of phosphoribosylaminoimidazolesuccinocarboxamide synthase from the yeast Saccharomyces cerevisiae
J. Mol. Biol.
228
298-299
1992
Saccharomyces cerevisiae
Meyer, E.; Leonard, N.J.; Bhat, B.; Stubbe, J.; Smith, J.M.
Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway
Biochemistry
31
5022-5032
1992
Escherichia coli
Senecoff, J.F.; McKinney, E.C.; Meagher, R.B.
De novo purine synthesis in Arabidopsis thaliana. II. The PUR7 gene encoding 5-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole synthetase is expressed in rapidly dividing tissues
Plant Physiol.
112
905-917
1996
Arabidopsis thaliana
Rowe, P.B.; McCairns, E.; Madsen, G.; Sauer, D.; Elliott, H.
De novo purine synthesis in avian liver. Co-purification of the enzymes and properties of the pathway
J. Biol. Chem.
253
7711-7721
1978
Pigeon
Meyer, E.; Kappock, T.J.; Osuji, C.; Stubbe, J.
Evidence for the Direct Transfer of the carboxylate of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to generate 4-carboxy-5-aminoimidazole ribonucleotide catalyzed by Escherichia coli PurE, an N5-CAIR mutase
Biochemistry
38
3012-3018
1999
Escherichia coli
Urusova, D.V.; Antonyuk, S.V.; Grebenko, A.I.; Lamzin, V.S.; Melik-Adamyan, V.R.
X-ray diffraction study of the complex of the enzyme SAICAR synthase with substrate analogs
Crystallogr. Rep.
48
763-767
2003
Saccharomyces cerevisiae
-
O'Donnell, A.F.; Tiong, S.; Nash, D.; Clark, D.V.
The Drosophila melanogaster ade5 gene encodes a bifunctional enzyme for two steps in the de novo purine synthesis pathway
Genetics
154
1239-1253
2000
Drosophila melanogaster (Q9I7S8), Drosophila melanogaster
Levdikov, V.M.; Barynin, V.V.; Grebenko, A.I.; Melik-Adamyan, W.R.; Lamzin, V.S.; Wilson, K.S.
The structure of SAICAR synthase: an enzyme in the de novo pathway of purine nucleotide biosynthesis
Structure
6
363-376
1998
Saccharomyces cerevisiae (P27616), Saccharomyces cerevisiae
Nelson, S.W.; Binkowski, D.J.; Honzatko, R.B.; Fromm, H.J.
Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase
Biochemistry
44
766-774
2005
Escherichia coli
Zhang, R.; Skarina, T.; Evdokimova, E.; Edwards, A.; Savchenko, A.; Laskowski, R.; Cuff, M.E.; Joachimiak, A.
Structure of SAICAR synthase from Thermotoga maritima at 2.2 A reveals an unusual covalent dimer
Acta Crystallogr. Sect. F
62
335-339
2006
Thermotoga maritima
Urusova, D.V.; Levdikov, V.M.; Antonyuk, S.V.; Grebenko, A.I.; Lamzin, V.S.; Melik-Adamyan, V.R.
X-ray diffraction study of the complex of the enzyme SAICAR synthase with the reaction product
Crystallogr. Rep.
51
824-827
2006
Saccharomyces cerevisiae (P27616)
-
Ginder, N.D.; Binkowski, D.J.; Fromm, H.J.; Honzatko, R.B.
Nucleotide complexes of Escherichia coli phosphoribosylaminoimidazole succinocarboxamide synthetase
J. Biol. Chem.
281
20680-20688
2006
Escherichia coli (P0A7D7), Escherichia coli
Li, S.; Tong, Y.; Xie, X.; Wang, Q.; Zhou, H.; Han, Y.; Zhang, Z.; Gao, W.; Li, S.; Zhang, X.C.; Bi, R.
Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis
J. Mol. Biol.
366
1603-1614
2007
Homo sapiens
Zhang, Y.; Morar, M.; Ealick, S.E.
Structural biology of the purine biosynthetic pathway
Cell. Mol. Life Sci.
65
3699-3724
2008
Escherichia coli, Homo sapiens, Thermotoga maritima, Saccharomyces cerevisiae (P27616)
Manjunath, K.; Jeyakanthan, J.; Nakagawa, N.; Shinkai, A.; Yoshimura, M.; Kuramitsu, S.; Yokoyama, S.; Sekar, K.
Cloning, expression, purification, crystallization and preliminary X-ray crystallographic study of the putative SAICAR synthetase (PH0239) from Pyrococcus horikoshii OT3
Acta Crystallogr. Sect. F
66
180-183
2010
Pyrococcus horikoshii OT3 (O57978), Pyrococcus horikoshii OT3
Ng, A.; Uribe, R.A.; Yieh, L.; Nuckels, R.; Gross, J.M.
Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development
Development
136
2601-2611
2009
Danio rerio
Cheng, X.; Lu, G.; Qi, J.; Cheng, H.; Gao, F.; Wang, J.; Yan, J.
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of SAICAR synthase from Streptococcus suis serotype 2
Acta Crystallogr. Sect. F
66
909-912
2010
Streptococcus suis
Manjunath, K.; Kanaujia, S.P.; Kanagaraj, S.; Jeyakanthan, J.; Sekar, K.
Structure of SAICAR synthetase from Pyrococcus horikoshii OT3: insights into thermal stability
Int. J. Biol. Macromol.
53
7-19
2013
Pyrococcus horikoshii (O57978), Pyrococcus horikoshii OT-3 (O57978)
Manjunath, K.; Sekar, K.
Molecular dynamics perspective on the protein thermal stability: a case study using SAICAR synthetase
J. Chem. Inf. Model.
53
2448-2461
2013
Escherichia coli, Ehrlichia chaffeensis, Geobacillus kaustophilus, Pyrococcus horikoshii (O57978), Methanocaldococcus jannaschii (Q58987), Pyrococcus horikoshii DSM 12428 (O57978), Methanocaldococcus jannaschii DSM 2661 (Q58987)
Taschner, M.; Basquin, J.; Benda, C.; Lorentzen, E.
Crystal structure of the invertebrate bifunctional purine biosynthesis enzyme PAICS at 2.8 A resolution
Proteins
81
1473-1478
2013
Trichoplusia ni
Manjunath, K.; Jeyakanthan, J.; Sekar, K.
Catalytic pathway, substrate binding and stability in SAICAR synthetase: A structure and molecular dynamics study
J. Struct. Biol.
191
22-31
2015
Pyrococcus horikoshii (O57978), Pyrococcus horikoshii, Pyrococcus horikoshii OT-3 (O57978)
Wolf, N.M.; Abad-Zapatero, C.; Johnson, M.E.; Fung, L.W.
Structures of SAICAR synthetase (PurC) from Streptococcus pneumoniae with ADP, Mg2+, AIR and Asp
Acta Crystallogr. Sect. D
70
841-850
2014
Streptococcus pneumoniae, Streptococcus pneumoniae ATCC 33400
Goswami, M.T.; Chen, G.; Chakravarthi, B.V.; Pathi, S.S.; Anand, S.K.; Carskadon, S.L.; Giordano, T.J.; Chinnaiyan, A.M.; Thomas, D.G.; Palanisamy, N.; Beer, D.G.; Varambally, S.
Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer
Oncotarget
6
23445-23461
2015
Homo sapiens
Suparmin, A.; Kato, T.; Dohra, H.; Park, E.Y.
Insight into cordycepin biosynthesis of Cordyceps militaris comparison between a liquid surface culture and a submerged culture through transcriptomic analysis
PLoS ONE
12
e0187052
2017
Cordyceps militaris (G3JF09), Cordyceps militaris CM01 (G3JF09)
Tuntland, M.L.; Wolf, N.M.; Fung, L.W.
Differences in the purification and solution properties of PurC gene products from Streptococcus pneumoniae and Bacillus anthracis
Protein Expr. Purif.
114
143-148
2015
Streptococcus pneumoniae (Q07296), Streptococcus pneumoniae, Bacillus anthracis (Q81ZH5), Bacillus anthracis, Streptococcus pneumoniae ATCC BAA-334 / TIGR4 (Q07296)
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