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Information on EC 6.2.1.49 - long-chain fatty acid adenylyltransferase FadD28

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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.49 long-chain fatty acid adenylyltransferase FadD28
IUBMB Comments
The enzyme, found in certain mycobacteria, activates long-chain fatty acids by adenylation and transfers them to EC 2.3.1.111, mycocerosate synthase. The enzyme participates in the biosynthesis of the virulent lipids dimycocerosates (DIM) and dimycocerosyl triglycosyl phenolphthiocerol (PGL).
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Word Map
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The expected taxonomic range for this enzyme is: Mycobacterium
Reaction Schemes
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ATP
+
a long-chain fatty acid
+
holo-[mycocerosate synthase]
=
AMP
+
diphosphate
+
a long-chain acyl-[mycocerosate synthase]
+
+
holo-[mycocerosate synthase]
=
+
+
a long-chain acyl-[mycocerosate synthase]
Synonyms
fadd28, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a long-chain acyl-adenylate ester + holo-[mycocerosate synthase] = AMP + a long-chain acyl-[mycocerosate synthase]
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(1b)
-
-
-
ATP + a long-chain fatty acid + holo-[mycocerosate synthase] = AMP + diphosphate + a long-chain acyl-[mycocerosate synthase]
show the reaction diagram
overall reaction
-
-
-
ATP + a long-chain fatty acid = diphosphate + a long-chain acyl-adenylate ester
show the reaction diagram
(1a)
-
-
-
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