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ATP + 4-aminobenzoate + CoA
AMP + 4-aminobenzoyl-CoA + diphosphate
-
30% of the activity with 4-hydroxybenzoate
-
-
?
ATP + 4-fluorobenzoate + CoA
AMP + 4-fluorobenzoyl-CoA + diphosphate
-
3.8% of the activity with 4-hydroxybenzoate
-
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
ATP + phenylacetate + CoA
AMP + phenylacetyl-CoA + diphosphate
-
4.5% of the activity with 4-hydroxybenzoate
-
-
?
CTP + 4-hydroxybenzoate + CoA
CMP + 4-hydroxybenzoyl-CoA + diphosphate
additional information
?
-
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
-
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
the bifunctional enzyme is also active with 3-hydroxybenzoate (at 44% of the activity with 4-hydroxybenzoate) (cf. EC 6.2.1.37)
-
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
-
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
the bifunctional enzyme is also active with 3-hydroxybenzoate (at 44% of the activity with 4-hydroxybenzoate) (cf. EC 6.2.1.37)
-
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
the bifunctional enzyme is also active with 3-hydroxybenzoate (cf. EC 6.2.1.37). Activity with 4-hydroxybenzoate is 17% of the activity with 3-hydroxybenzoate
-
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
-
-
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
the enzyme is involved in xanthone biosynthesis
-
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
the bifunctional enzyme is also active with 3-hydroxybenzoate (cf. EC 6.2.1.37). Activity with 4-hydroxybenzoate is 69% compared to 3-hydroxybenzoate
-
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
highly specific
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
anaerob
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
initial step of anaerobic 4-hydroxybenzoate degradation
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
highly specific
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
anaerob
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
initial step of anaerobic 4-hydroxybenzoate degradation
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
anaerob
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
initial step of anaerobic 4-hydroxybenzoate degradation
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
anaerob
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
initial step of anaerobic 4-hydroxybenzoate degradation
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
the bifunctional enzyme is also active with 3-hydroxybenzoate (cf. EC 6.2.1.37)
-
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
the enzyme is involved in the anaerobic hydroxybenzoate metabolism
-
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
the bifunctional enzyme is also active with 3-hydroxybenzoate (cf. EC 6.2.1.37). Activity with 4-hydroxybenzoate is 83% of the activity with 3-hydroxybenzoate
-
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
the bifunctional enzyme is also active with 3-hydroxybenzoate (cf. EC 6.2.1.37). kcat/Km for 4-hydroxybenzoate is 75% compared to the value for 3-hydroxybenzoate
-
-
?
CTP + 4-hydroxybenzoate + CoA
CMP + 4-hydroxybenzoyl-CoA + diphosphate
-
60% of the activity with ATP
-
-
?
CTP + 4-hydroxybenzoate + CoA
CMP + 4-hydroxybenzoyl-CoA + diphosphate
-
60% of the activity with ATP
-
-
?
additional information
?
-
-
no activity with 2-hydroxybenzoate, 2,3-dihydroxybenzoate, 3,4-dihydroxybenzoate, 3,5-dihydroxybenzoate and cinnamic acid
-
-
?
additional information
?
-
-
not: benzoate, 3- or 2-hydroxybenzoate
-
-
?
additional information
?
-
-
not: benzoate, 3- or 2-hydroxybenzoate
-
-
?
additional information
?
-
the enzyme shows low activity towards benzoate, 4-aminobenzoate, 3-aminobenzoate, 3-fluorobenzoate, 4-fluorobenzoate, 3-chlorobenzoate, and 4-chlorobenzoate. There is no activity with 3,4-dihydroxybenzoate, 2,3-dihydroxybenzoate, and 2-hydroxybenzoate as substrates
-
-
?
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ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
-
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
-
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
the enzyme is involved in xanthone biosynthesis
-
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
initial step of anaerobic 4-hydroxybenzoate degradation
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
initial step of anaerobic 4-hydroxybenzoate degradation
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
initial step of anaerobic 4-hydroxybenzoate degradation
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
initial step of anaerobic 4-hydroxybenzoate degradation
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
the bifunctional enzyme is also active with 3-hydroxybenzoate (cf. EC 6.2.1.37)
-
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
the enzyme is involved in the anaerobic hydroxybenzoate metabolism
-
-
?
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Barillas, W.; Beerhues, L.
3-Hydroxybenzoate:coenzyme A ligase and 4-coumarate:coenzyme A ligase from cultured cells of Centaurium erythraea
Planta
202
112-116
1997
Centaurium erythraea
brenda
Schmidt, W.; Beerhues, L.
Alternative pathways of xanthone biosynthesis in cell cultures of Hypericum androsaemum
FEBS Lett.
420
143-146
1997
Hypericum androsaemum
brenda
Heider, J.; Boll, M.; Breese, K.; Breinig, S.; Ebenau-Jehle, C.; Feil, U.; Gad'on, N.; Laempe, D.; Leuthner, B.; Mohamed, M.E.S.; Schneider, S.; Burchhardt, G.; Fuchs, G.
Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica
Arch. Microbiol.
170
120-131
1998
Thauera aromatica
brenda
Merkel, S.M.; Eberhard, A.E.; Gibson, J.; Harwood, C.S.
Involvement of coenzyme A thioesters in anaerobic metabolism of 4-hydroxybenzoate by Rhosopseudomonas palustris
J. Bacteriol.
171
1-7
1989
Rhodopseudomonas palustris
brenda
Biegert, T.; Altenschmidt, U.; Eckerskorn, C.; Fuchs, G.
Enzymes of anarobic metabolism pf phenolic compounds. 4-Hydroxybenzoate-CoA ligase from a denitrifying Pseudomonas species
Eur. J. Biochem.
213
555-561
1993
Pseudomonas sp., Pseudomonas sp. K172
brenda
Peters, F.; Heintz, D.; Johannes, J.; van Dorsselaer, A.; Boll, M.
Genes, enzymes, and regulation of para-cresol metabolism in Geobacter metallireducens
J. Bacteriol.
189
4729-4738
2007
Geobacter metallireducens
brenda
Laempe, D.; Jahn, M.; Breese, K.; Schgger, H.; Fuchs, G.
Anaerobic metabolism of 3-hydroxybenzoate by the denitrifying bacterium Thauera aromatica
J. Bacteriol.
183
968-979
2001
Thauera aromatica (Q9AJS8)
brenda
Ding, B.; Schmeling, S.; Fuchs, G.
Anaerobic metabolism of catechol by the denitrifying bacterium Thauera aromatica - a result of promiscuous enzymes and regulators?
J. Bacteriol.
190
1620-1630
2007
Azoarcus sp. (Q5P0J2), Thauera aromatica (Q9AJS8), Azoarcus sp. EbN1 (Q5P0J2)
brenda