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ATP + 1-cyclohexene-carboxylate + CoA
AMP + diphosphate + 1-cyclohexene-carboxyl-CoA
-
-
-
?
ATP + 2-aminobenzoate + CoA
AMP + diphosphate + 2-aminobenzoyl-CoA
ATP + 2-chlorobenzoate + CoA
AMP + diphosphate + 2-chlorobenzoyl-CoA
ATP + 2-cyanobenzoate + CoA
AMP + diphosphate + 2-cyanobenzoyl-CoA
-
-
-
?
ATP + 2-fluorobenzoate + CoA
AMP + diphosphate + 2-fluorobenzoyl-CoA
ATP + 2-hydroxybenzoate + CoA
AMP + diphosphate + 2-hydroxybenzoyl-CoA
ATP + 2-methoxybenzoate + CoA
AMP + diphosphate + 2-methoxybenzoyl-CoA
-
-
-
?
ATP + 2-methylbenzoate + CoA
AMP + diphosphate + 2-methylbenzoyl-CoA
ATP + 2-nitrobenzoate + CoA
AMP + diphosphate + 2-nitrobenzoyl-CoA
-
-
-
?
ATP + 3-aminobenzoate + CoA
AMP + diphosphate + 3-aminobenzoyl-CoA
ATP + 3-chlorobenzoate + CoA
AMP + diphosphate + 3-chlorobenzoyl-CoA
ATP + 3-cyanobenzoate + CoA
AMP + diphosphate + 3-chlorobenzoyl-CoA
-
-
-
?
ATP + 3-cyclohexene-carboxylate + CoA
AMP + diphosphate + 3-cyclohexene-carboxyl-CoA
-
-
-
?
ATP + 3-fluorobenzoate + CoA
AMP + diphosphate + 3-fluorobenzoyl-CoA
ATP + 3-furoate + CoA
AMP + diphosphate + 3-furoyl-CoA
-
-
-
?
ATP + 3-hydroxybenzoate + CoA
AMP + diphosphate + 3-hydroxybenzoyl-CoA
ATP + 3-methylbenzoate + CoA
AMP + diphosphate + 3-methylbenzoyl-CoA
-
-
-
?
ATP + 4-aminobenzoate + CoA
AMP + diphosphate + 4-aminobenzoyl-CoA
ATP + 4-chlorobenzoate + CoA
AMP + diphosphate + 4-chlorobenzoyl-CoA
ATP + 4-fluorobenzoate + CoA
AMP + diphosphate + 4-fluorobenzoyl-CoA
ATP + 4-hydroxy-3-methoxybenzoate + CoA
AMP + diphosphate + 4-hydroxy-3-methoxybenzoyl-CoA
-
15% of the activity relative to benzoate
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
ATP + 4-methylbenzoate + CoA
AMP + diphosphate + 4-methylbenzoyl-CoA
-
-
-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
-
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
ATP + cyclohex-1-ene-1-carboxylate + CoA
AMP + diphosphate + cyclohex-1-ene-1-carbonyl-CoA
-
8% of the activity relative to benzoate
-
?
ATP + cyclohex-1-ene-1-carboxylate + CoA
AMP + diphosphate + cyclohex-1-ene-1-carboxyl-CoA
-
13% of the activity with benzoate
-
-
?
ATP + cyclohex-3-ene-1-carboxylate + CoA
AMP + diphosphate + cyclohex-1-ene-1-carboxyl-CoA
-
40% of the activity with benzoate
-
-
?
ATP + cyclohexa-1,5-diene-1-carboxylate + CoA
AMP + diphosphate + cyclohexa-1,5-diene-1-carboxyl-CoA
-
23% of the activity relative to benzoate
-
?
ATP + cyclohexane carboxylate + CoA
AMP + diphosphate + cyclohexane carboxyl-CoA
-
-
-
?
ATP + cyclohexanecarboxylate + CoA
AMP + diphosphate + cyclohexanecarboxyl-CoA
-
7% of the activity with benzoate
-
-
?
ATP + DELTA1-cyclohexenecarboxylate + CoA
AMP + diphosphate + DELTA1-cyclohexenecarboxyl-CoA
ATP + DELTA3-cyclohexenecarboxylate + CoA
AMP + diphosphate + DELTA3-cyclohexenecarboxyl-CoA
ATP + glutarate + CoA
AMP + diphosphate + glutaryl-CoA
-
-
-
?
ATP + isonicotinate + CoA
AMP + diphosphate + isonicotinyl-CoA
ATP + nicotinate + CoA
AMP + diphosphate + nicotinyl-CoA
ATP + phenylacetate + CoA
AMP + diphosphate + phenylacetyl-CoA
ATP + phenylpropionate + CoA
AMP + diphosphate + phenylpropionyl-CoA
-
10% of the activity relative to benzoate
-
?
ATP + picolinate + CoA
AMP + diphosphate + picolinyl-CoA
ATP + thiophene-2-carboxylate + CoA
AMP + diphosphate + thiophene-2-carboxyl-CoA
-
-
-
?
additional information
?
-
ATP + 2-aminobenzoate + CoA
AMP + diphosphate + 2-aminobenzoyl-CoA
-
35% of the activity with benzoate
-
-
?
ATP + 2-aminobenzoate + CoA
AMP + diphosphate + 2-aminobenzoyl-CoA
-
50% of the activity relative to benzoate
-
?
ATP + 2-aminobenzoate + CoA
AMP + diphosphate + 2-aminobenzoyl-CoA
-
3% of the activity with benzoate
-
-
?
ATP + 2-aminobenzoate + CoA
AMP + diphosphate + 2-aminobenzoyl-CoA
6.7% and 10% activity in aerobically and anaerobically grown cells, respectively, compared to the activity with benzoate
-
-
?
ATP + 2-aminobenzoate + CoA
AMP + diphosphate + 2-aminobenzoyl-CoA
-
12.7% activity compared to benzoate
-
-
?
ATP + 2-aminobenzoate + CoA
AMP + diphosphate + 2-aminobenzoyl-CoA
-
-
-
-
?
ATP + 2-aminobenzoate + CoA
AMP + diphosphate + 2-aminobenzoyl-CoA
-
28% of the activity relative to benzoate
-
-
?
ATP + 2-aminobenzoate + CoA
AMP + diphosphate + 2-aminobenzoyl-CoA
-
-
-
-
?
ATP + 2-aminobenzoate + CoA
AMP + diphosphate + 2-aminobenzoyl-CoA
-
28% of the activity relative to benzoate
-
-
?
ATP + 2-aminobenzoate + CoA
AMP + diphosphate + 2-aminobenzoyl-CoA
-
-
-
-
?
ATP + 2-aminobenzoate + CoA
AMP + diphosphate + 2-aminobenzoyl-CoA
-
-
-
?
ATP + 2-aminobenzoate + CoA
AMP + diphosphate + 2-aminobenzoyl-CoA
-
60% of the activity relative to benzoate
-
?
ATP + 2-chlorobenzoate + CoA
AMP + diphosphate + 2-chlorobenzoyl-CoA
-
5% of the activity with benzoate
-
-
?
ATP + 2-chlorobenzoate + CoA
AMP + diphosphate + 2-chlorobenzoyl-CoA
-
-
-
?
ATP + 2-chlorobenzoate + CoA
AMP + diphosphate + 2-chlorobenzoyl-CoA
-
10% of the activity relative to benzoate
-
-
?
ATP + 2-fluorobenzoate + CoA
AMP + diphosphate + 2-fluorobenzoyl-CoA
Anaerobic bacterium
-
93% of the activity relative to benzoate
-
-
?
ATP + 2-fluorobenzoate + CoA
AMP + diphosphate + 2-fluorobenzoyl-CoA
-
91% of the activity with benzoate
-
-
?
ATP + 2-fluorobenzoate + CoA
AMP + diphosphate + 2-fluorobenzoyl-CoA
-
92% of the activity with benzoate
-
-
?
ATP + 2-fluorobenzoate + CoA
AMP + diphosphate + 2-fluorobenzoyl-CoA
61% and 57% activity in aerobically and anaerobically grown cells, respectively, compared to the activity with benzoate
-
-
?
ATP + 2-fluorobenzoate + CoA
AMP + diphosphate + 2-fluorobenzoyl-CoA
61% and 57% activity in aerobically and anaerobically grown cells, respectively, compared to the activity with benzoate
-
-
?
ATP + 2-fluorobenzoate + CoA
AMP + diphosphate + 2-fluorobenzoyl-CoA
-
1.9% activity compared to benzoate
-
-
?
ATP + 2-fluorobenzoate + CoA
AMP + diphosphate + 2-fluorobenzoyl-CoA
-
-
-
-
?
ATP + 2-fluorobenzoate + CoA
AMP + diphosphate + 2-fluorobenzoyl-CoA
-
120% of the activity relative to benzoate
-
-
?
ATP + 2-fluorobenzoate + CoA
AMP + diphosphate + 2-fluorobenzoyl-CoA
-
as effective as benzoate
-
-
?
ATP + 2-fluorobenzoate + CoA
AMP + diphosphate + 2-fluorobenzoyl-CoA
-
135% of the activity relative to benzoate
-
-
?
ATP + 2-fluorobenzoate + CoA
AMP + diphosphate + 2-fluorobenzoyl-CoA
-
-
-
-
?
ATP + 2-fluorobenzoate + CoA
AMP + diphosphate + 2-fluorobenzoyl-CoA
-
as effective as benzoate
-
-
?
ATP + 2-fluorobenzoate + CoA
AMP + diphosphate + 2-fluorobenzoyl-CoA
-
135% of the activity relative to benzoate
-
-
?
ATP + 2-fluorobenzoate + CoA
AMP + diphosphate + 2-fluorobenzoyl-CoA
-
120% of the activity relative to benzoate
-
-
?
ATP + 2-fluorobenzoate + CoA
AMP + diphosphate + 2-fluorobenzoyl-CoA
-
-
-
-
?
ATP + 2-fluorobenzoate + CoA
AMP + diphosphate + 2-fluorobenzoyl-CoA
-
-
-
?
ATP + 2-fluorobenzoate + CoA
AMP + diphosphate + 2-fluorobenzoyl-CoA
-
102% of the activity relative to benzoate
-
-
?
ATP + 2-fluorobenzoate + CoA
AMP + diphosphate + 2-fluorobenzoyl-CoA
-
122% of the activity relative to benzoate
-
?
ATP + 2-fluorobenzoate + CoA
AMP + diphosphate + 2-fluorobenzoyl-CoA
activation of 2-fluorobenzoate by promiscuous AMP-forming benzoate-CoA ligase
-
-
?
ATP + 2-hydroxybenzoate + CoA
AMP + diphosphate + 2-hydroxybenzoyl-CoA
-
15% of the activity relative to benzoate
-
?
ATP + 2-hydroxybenzoate + CoA
AMP + diphosphate + 2-hydroxybenzoyl-CoA
-
-
-
?
ATP + 2-methylbenzoate + CoA
AMP + diphosphate + 2-methylbenzoyl-CoA
-
no activity with anaerobically induced enzyme, 15% of the activity relative to benzoate with the aerobically induced enzyme
-
-
?
ATP + 2-methylbenzoate + CoA
AMP + diphosphate + 2-methylbenzoyl-CoA
-
-
-
?
ATP + 3-aminobenzoate + CoA
AMP + diphosphate + 3-aminobenzoyl-CoA
3.7% activity in anaerobically grown cells, compared to the activity with benzoate
-
-
?
ATP + 3-aminobenzoate + CoA
AMP + diphosphate + 3-aminobenzoyl-CoA
-
-
-
?
ATP + 3-chlorobenzoate + CoA
AMP + diphosphate + 3-chlorobenzoyl-CoA
-
13% of the activity with benzoate
-
-
?
ATP + 3-chlorobenzoate + CoA
AMP + diphosphate + 3-chlorobenzoyl-CoA
-
-
-
?
ATP + 3-fluorobenzoate + CoA
AMP + diphosphate + 3-fluorobenzoyl-CoA
Anaerobic bacterium
-
56% of the activity relative to benzoate
-
-
?
ATP + 3-fluorobenzoate + CoA
AMP + diphosphate + 3-fluorobenzoyl-CoA
-
92% of the activity with benzoate
-
-
?
ATP + 3-fluorobenzoate + CoA
AMP + diphosphate + 3-fluorobenzoyl-CoA
-
23% of the activity with benzoate
-
-
?
ATP + 3-fluorobenzoate + CoA
AMP + diphosphate + 3-fluorobenzoyl-CoA
16% activity in aerobically and anaerobically grown cells, compared to the activity with benzoate
-
-
?
ATP + 3-fluorobenzoate + CoA
AMP + diphosphate + 3-fluorobenzoyl-CoA
16% activity in aerobically and anaerobically grown cells, compared to the activity with benzoate
-
-
?
ATP + 3-fluorobenzoate + CoA
AMP + diphosphate + 3-fluorobenzoyl-CoA
-
2.0% activity compared to benzoate
-
-
?
ATP + 3-fluorobenzoate + CoA
AMP + diphosphate + 3-fluorobenzoyl-CoA
-
-
-
-
?
ATP + 3-fluorobenzoate + CoA
AMP + diphosphate + 3-fluorobenzoyl-CoA
-
98% of the activity relative to benzoate
-
-
?
ATP + 3-fluorobenzoate + CoA
AMP + diphosphate + 3-fluorobenzoyl-CoA
-
80% of the activity relative to benzoate
-
-
?
ATP + 3-fluorobenzoate + CoA
AMP + diphosphate + 3-fluorobenzoyl-CoA
-
76% of the activity relative to benzoate
-
-
?
ATP + 3-fluorobenzoate + CoA
AMP + diphosphate + 3-fluorobenzoyl-CoA
-
98% of the activity relative to benzoate
-
-
?
ATP + 3-fluorobenzoate + CoA
AMP + diphosphate + 3-fluorobenzoyl-CoA
-
80% of the activity relative to benzoate
-
-
?
ATP + 3-fluorobenzoate + CoA
AMP + diphosphate + 3-fluorobenzoyl-CoA
-
76% of the activity relative to benzoate
-
-
?
ATP + 3-fluorobenzoate + CoA
AMP + diphosphate + 3-fluorobenzoyl-CoA
-
-
-
?
ATP + 3-fluorobenzoate + CoA
AMP + diphosphate + 3-fluorobenzoyl-CoA
-
89% of the activity relative to benzoate
-
?
ATP + 3-hydroxybenzoate + CoA
AMP + diphosphate + 3-hydroxybenzoyl-CoA
-
8% of the activity with benzoate, no activity is observed when ATP is replaced by GTP
-
-
?
ATP + 3-hydroxybenzoate + CoA
AMP + diphosphate + 3-hydroxybenzoyl-CoA
-
10% of the activity relative to benzoate
-
?
ATP + 3-hydroxybenzoate + CoA
AMP + diphosphate + 3-hydroxybenzoyl-CoA
-
1.1% activity compared to benzoate
-
-
?
ATP + 3-hydroxybenzoate + CoA
AMP + diphosphate + 3-hydroxybenzoyl-CoA
-
-
-
?
ATP + 3-hydroxybenzoate + CoA
AMP + diphosphate + 3-hydroxybenzoyl-CoA
-
-
-
?
ATP + 4-aminobenzoate + CoA
AMP + diphosphate + 4-aminobenzoyl-CoA
5.6% activity in anaerobically grown cells, compared to the activity with benzoate
-
-
?
ATP + 4-aminobenzoate + CoA
AMP + diphosphate + 4-aminobenzoyl-CoA
-
-
-
?
ATP + 4-chlorobenzoate + CoA
AMP + diphosphate + 4-chlorobenzoyl-CoA
-
3% of the activity with benzoate
-
-
?
ATP + 4-chlorobenzoate + CoA
AMP + diphosphate + 4-chlorobenzoyl-CoA
-
-
-
?
ATP + 4-fluorobenzoate + CoA
AMP + diphosphate + 4-fluorobenzoyl-CoA
Anaerobic bacterium
-
75% of the activity relative to benzoate
-
-
?
ATP + 4-fluorobenzoate + CoA
AMP + diphosphate + 4-fluorobenzoyl-CoA
-
84% of the activity with benzoate
-
-
?
ATP + 4-fluorobenzoate + CoA
AMP + diphosphate + 4-fluorobenzoyl-CoA
-
98% of the activity with benzoate
-
-
?
ATP + 4-fluorobenzoate + CoA
AMP + diphosphate + 4-fluorobenzoyl-CoA
72% and 69% activity in aerobically and anaerobically grown cells, respectively, compared to the activity with benzoate
-
-
?
ATP + 4-fluorobenzoate + CoA
AMP + diphosphate + 4-fluorobenzoyl-CoA
72% and 69% activity in aerobically and anaerobically grown cells, respectively, compared to the activity with benzoate
-
-
?
ATP + 4-fluorobenzoate + CoA
AMP + diphosphate + 4-fluorobenzoyl-CoA
-
1.4% activity compared to benzoate
-
-
?
ATP + 4-fluorobenzoate + CoA
AMP + diphosphate + 4-fluorobenzoyl-CoA
-
-
-
-
?
ATP + 4-fluorobenzoate + CoA
AMP + diphosphate + 4-fluorobenzoyl-CoA
-
as effective as benzoate
-
-
?
ATP + 4-fluorobenzoate + CoA
AMP + diphosphate + 4-fluorobenzoyl-CoA
-
79% of the activity relative to benzoate
-
-
?
ATP + 4-fluorobenzoate + CoA
AMP + diphosphate + 4-fluorobenzoyl-CoA
-
145% of the activity relative to benzoate
-
-
?
ATP + 4-fluorobenzoate + CoA
AMP + diphosphate + 4-fluorobenzoyl-CoA
-
79% of the activity relative to benzoate
-
-
?
ATP + 4-fluorobenzoate + CoA
AMP + diphosphate + 4-fluorobenzoyl-CoA
-
145% of the activity relative to benzoate
-
-
?
ATP + 4-fluorobenzoate + CoA
AMP + diphosphate + 4-fluorobenzoyl-CoA
-
as effective as benzoate
-
-
?
ATP + 4-fluorobenzoate + CoA
AMP + diphosphate + 4-fluorobenzoyl-CoA
-
-
-
-
?
ATP + 4-fluorobenzoate + CoA
AMP + diphosphate + 4-fluorobenzoyl-CoA
-
-
-
?
ATP + 4-fluorobenzoate + CoA
AMP + diphosphate + 4-fluorobenzoyl-CoA
-
72% of the activity relative to benzoate
-
-
?
ATP + 4-fluorobenzoate + CoA
AMP + diphosphate + 4-fluorobenzoyl-CoA
-
100% of the activity relative to benzoate
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
16% of the activity with benzoate, no activity is observed when ATP is replaced by GTP
-
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
25% of the activity relative to benzoate
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
1.0% activity compared to benzoate
-
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
-
-
?
ATP + 4-hydroxybenzoate + CoA
AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
-
-
?
ATP + benzoate + CoA
?
-
enzyme is involved in anaerobic degradation of benzoate
-
-
?
ATP + benzoate + CoA
?
-
activation of benzoate to benzoyl-CoA, a more polar and nondiffusable molecule, decreases the concentration of benzoate in the cell, creating a gradient that favored the uptake of benzoate from the environment
-
-
?
ATP + benzoate + CoA
?
-
first step of anaerobic benzoate degradation
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
Anaerobic bacterium
-
-
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
-
-
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
-
-
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
-
-
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
-
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
-
-
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
-
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
-
the enzyme catalyzes the initial step of benzoate metabolism
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
-
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
100% activity in aerobically and anaerobically grown cells
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
100% activity in aerobically and anaerobically grown cells
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
-
100% activity
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
-
-
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
-
-
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
-
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
-
-
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
-
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
-
-
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
-
-
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
-
-
-
?
ATP + benzoate + CoA
AMP + diphosphate + benzoyl-CoA
-
-
-
?
ATP + DELTA1-cyclohexenecarboxylate + CoA
AMP + diphosphate + DELTA1-cyclohexenecarboxyl-CoA
-
-
-
-
?
ATP + DELTA1-cyclohexenecarboxylate + CoA
AMP + diphosphate + DELTA1-cyclohexenecarboxyl-CoA
-
13% of the activity relative to benzoate
-
-
?
ATP + DELTA3-cyclohexenecarboxylate + CoA
AMP + diphosphate + DELTA3-cyclohexenecarboxyl-CoA
-
-
-
-
?
ATP + DELTA3-cyclohexenecarboxylate + CoA
AMP + diphosphate + DELTA3-cyclohexenecarboxyl-CoA
-
54% of the activity relative to benzoate
-
-
?
ATP + isonicotinate + CoA
AMP + diphosphate + isonicotinyl-CoA
Anaerobic bacterium
-
29% of the activity relative to benzoate
-
-
?
ATP + isonicotinate + CoA
AMP + diphosphate + isonicotinyl-CoA
-
95% of the activity with benzoate
-
-
?
ATP + nicotinate + CoA
AMP + diphosphate + nicotinyl-CoA
Anaerobic bacterium
-
11% of the activity relative to benzoate
-
-
?
ATP + nicotinate + CoA
AMP + diphosphate + nicotinyl-CoA
-
32% of the activity with benzoate
-
-
?
ATP + nicotinate + CoA
AMP + diphosphate + nicotinyl-CoA
-
12% of the activity relative to benzoate
-
-
?
ATP + phenylacetate + CoA
AMP + diphosphate + phenylacetyl-CoA
-
10% of the activity relative to benzoate
-
?
ATP + phenylacetate + CoA
AMP + diphosphate + phenylacetyl-CoA
-
-
-
?
ATP + picolinate + CoA
AMP + diphosphate + picolinyl-CoA
Anaerobic bacterium
-
46% of the activity relative to benzoate
-
-
?
ATP + picolinate + CoA
AMP + diphosphate + picolinyl-CoA
3.4% and 2.7% activity in aerobically and anaerobically grown cells, respectively, compared to the activity with benzoate
-
-
?
ATP + picolinate + CoA
AMP + diphosphate + picolinyl-CoA
-
-
-
-
?
ATP + picolinate + CoA
AMP + diphosphate + picolinyl-CoA
-
45% of the activity relative to benzoate
-
-
?
additional information
?
-
-
benzoate degradation in Azoarcus sp. strain CIB is subject to carbon catabolic repression by some organic acids, indicating the existence of a physiological control that connects the expression of the bzd genes to the metabolic status of the cell
-
-
?
additional information
?
-
-
no reaction with cinnamic, coumaric, ferulic, caffeic, p-aminobenzoic, octanoic, or 2,5-dihydroxybenzoic acid
-
?
additional information
?
-
little or no activity with 2-hydroxybenzoate, 3-hydroxybenzoate, 4-hydroxybenzoate, 2-chlorobenzoate, 3-chlorobenzoate, 4-chlorobenzoate, cyclohexane carboxylate, and nicotinate
-
-
?
additional information
?
-
-
little or no activity with 2-hydroxybenzoate, 3-hydroxybenzoate, 4-hydroxybenzoate, 2-chlorobenzoate, 3-chlorobenzoate, 4-chlorobenzoate, cyclohexane carboxylate, and nicotinate
-
-
?
additional information
?
-
little or no activity with 2-hydroxybenzoate, 3-hydroxybenzoate, 4-hydroxybenzoate, 2-chlorobenzoate, 3-chlorobenzoate, 4-chlorobenzoate, cyclohexane carboxylate, and nicotinate
-
-
?
additional information
?
-
-
no or less than 1% activity with 2-methylbenzoate, 4-methylbenzoate, 3-chlorobenzoate, 4-chlorobenzoate, 2-bromobenzoate, 3-bromobenzoate, 4-bromobenzoate, phenylacetate, acetate, succinate, propionate, butyrate, and hexanoate
-
-
?
additional information
?
-
-
not 3-hydroxybenzoate
-
-
?
additional information
?
-
-
not 3-hydroxybenzoate
-
-
?
additional information
?
-
-
no reaction with GTP
-
-
?
additional information
?
-
substrate specificity analysis using 31 additional potential substrates, analysis of active site architecture, overview. BadA converts ortho-substituted substrates better than the corresponding meta and para regioisomers, and the turnover number is more affected by steric rather than electronic effects, all the aryl carboxylates are uniquely oriented within the active site, relative to other structures. No or poor activity with 4-nitrobenzoate, 4-methoxybenzoate, 4-cyanobenzoate, 3-nitrobenzoate, 3-methoxybenzoate, 3-cyanobenzoate, cinnamate, and phenylacetate
-
-
?
additional information
?
-
-
substrate specificity analysis using 31 additional potential substrates, analysis of active site architecture, overview. BadA converts ortho-substituted substrates better than the corresponding meta and para regioisomers, and the turnover number is more affected by steric rather than electronic effects, all the aryl carboxylates are uniquely oriented within the active site, relative to other structures. No or poor activity with 4-nitrobenzoate, 4-methoxybenzoate, 4-cyanobenzoate, 3-nitrobenzoate, 3-methoxybenzoate, 3-cyanobenzoate, cinnamate, and phenylacetate
-
-
?
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