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alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
-
-
-
r
alpha-D-glucose 6-phosphate
alpha-D-glucose 1-phosphate
-
-
-
-
r
D-glucose-1-phosphate
D-glucose-6-phosphate
-
-
-
?
glucosamine 1-phosphate
glucosamine 6-phosphate
-
-
-
-
r
glucosamine 6-phosphate
glucosamine 1-phosphate
-
-
-
-
r
Glucose 1-phosphate
Glucose 6-phosphate
N-acetyl-alpha-D-glucosamine
?
-
-
-
?
N-acetyl-alpha-D-glucosamine 1-phosphate
N-acetyl-alpha-D-glucosamine 6-phosphate
N-acetyl-alpha-D-glucosamine 1-phosphate
N-acetyl-D-glucosamine 6-phosphate
N-acetyl-alpha-D-glucosamine 6-phosphate
N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
-
r
N-Acetyl-D-glucosamine 1-phosphate
N-Acetyl-D-glucosamine 6-phosphate
N-acetyl-D-glucosamine 6-phosphate
N-acetyl-alpha-D-glucosamine 1-phosphate
N-Acetylglucosamine 6-phosphate
?
N-Acetylglucosamine 6-phosphate
N-Acetylglucosamine 1-phosphate
N-acetylglucosamine-1-phosphate
N-acetylglucosamine-6-phosphate
-
-
-
?
additional information
?
-
Glucose 1-phosphate
Glucose 6-phosphate
-
-
-
?
Glucose 1-phosphate
Glucose 6-phosphate
-
-
-
?
Glucose 1-phosphate
Glucose 6-phosphate
-
in presence of glucose 1,6-diphosphate
-
?
N-acetyl-alpha-D-glucosamine 1-phosphate
N-acetyl-alpha-D-glucosamine 6-phosphate
-
-
-
-
r
N-acetyl-alpha-D-glucosamine 1-phosphate
N-acetyl-alpha-D-glucosamine 6-phosphate
-
-
-
r
N-acetyl-alpha-D-glucosamine 1-phosphate
N-acetyl-D-glucosamine 6-phosphate
-
-
?
N-acetyl-alpha-D-glucosamine 1-phosphate
N-acetyl-D-glucosamine 6-phosphate
-
-
-
-
?
N-acetyl-alpha-D-glucosamine 1-phosphate
N-acetyl-D-glucosamine 6-phosphate
-
-
-
-
?
N-acetyl-alpha-D-glucosamine 1-phosphate
N-acetyl-D-glucosamine 6-phosphate
-
-
?
N-acetyl-alpha-D-glucosamine 1-phosphate
N-acetyl-D-glucosamine 6-phosphate
-
-
-
r
N-acetyl-alpha-D-glucosamine 1-phosphate
N-acetyl-D-glucosamine 6-phosphate
-
-
-
r
N-Acetyl-D-glucosamine 1-phosphate
N-Acetyl-D-glucosamine 6-phosphate
-
-
-
-
?
N-Acetyl-D-glucosamine 1-phosphate
N-Acetyl-D-glucosamine 6-phosphate
-
specific for the alpha-1-phosphate anomer
-
-
?
N-Acetyl-D-glucosamine 1-phosphate
N-Acetyl-D-glucosamine 6-phosphate
-
-
-
-
?
N-Acetyl-D-glucosamine 1-phosphate
N-Acetyl-D-glucosamine 6-phosphate
-
in presence of N-acetylglucosamine 1,6-diphosphate
-
?
N-acetyl-D-glucosamine 6-phosphate
N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
r
N-acetyl-D-glucosamine 6-phosphate
N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
r
N-acetyl-D-glucosamine 6-phosphate
N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
r
N-Acetylglucosamine 6-phosphate
?
-
the reaction is involved in the synthesis of active glycosyl intermediates in reticulo-endothelial tissues
-
-
?
N-Acetylglucosamine 6-phosphate
?
Coffea sp.
-
enzyme in the pathway of UDP-N-acetyl-D-glucosamine formation
-
-
?
N-Acetylglucosamine 6-phosphate
?
-
enzyme is involved in galactosamine synthesis from glucose during encystment, induced during encystment
-
-
?
N-Acetylglucosamine 6-phosphate
?
-
enzyme is involved in galactosamine synthesis from glucose during encystment, induced during encystment
-
-
?
N-Acetylglucosamine 6-phosphate
N-Acetylglucosamine 1-phosphate
-
-
-
?
N-Acetylglucosamine 6-phosphate
N-Acetylglucosamine 1-phosphate
-
-
-
?
N-Acetylglucosamine 6-phosphate
N-Acetylglucosamine 1-phosphate
Coffea sp.
-
-
-
?
additional information
?
-
-
one of the two last pathway-specific enzymes of hexosamine biosynthesis. The hexosamine pathway is regulated at the post-translational level during zoospore germination
-
-
?
additional information
?
-
the enzyme exhibits the function of phosphoglucomutase, EC 5.4.2.2, whose gene is lost in Trypanosoma brucei, together with phosphomannomutase, EC 5.4.2.8, producing D-glucose 1-phosphate from D-glucose 6-phosphate, kinetics, overview
-
-
?
additional information
?
-
-
the enzyme exhibits the function of phosphoglucomutase, EC 5.4.2.2, whose gene is lost in Trypanosoma brucei, together with phosphomannomutase, EC 5.4.2.8, producing D-glucose 1-phosphate from D-glucose 6-phosphate, kinetics, overview
-
-
?
additional information
?
-
the enzyme exhibits the function of phosphoglucomutase, EC 5.4.2.2, whose gene is lost in Trypanosoma brucei, together with phosphomannomutase, EC 5.4.2.8, producing D-glucose 1-phosphate from D-glucose 6-phosphate, kinetics, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
N-acetyl-alpha-D-glucosamine 1-phosphate
N-acetyl-alpha-D-glucosamine 6-phosphate
N-acetyl-alpha-D-glucosamine 1-phosphate
N-acetyl-D-glucosamine 6-phosphate
N-acetyl-alpha-D-glucosamine 6-phosphate
N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
-
r
N-acetyl-D-glucosamine 6-phosphate
N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
r
N-Acetylglucosamine 6-phosphate
?
additional information
?
-
N-acetyl-alpha-D-glucosamine 1-phosphate
N-acetyl-alpha-D-glucosamine 6-phosphate
-
-
-
-
r
N-acetyl-alpha-D-glucosamine 1-phosphate
N-acetyl-alpha-D-glucosamine 6-phosphate
-
-
-
r
N-acetyl-alpha-D-glucosamine 1-phosphate
N-acetyl-D-glucosamine 6-phosphate
-
-
?
N-acetyl-alpha-D-glucosamine 1-phosphate
N-acetyl-D-glucosamine 6-phosphate
-
-
?
N-acetyl-alpha-D-glucosamine 1-phosphate
N-acetyl-D-glucosamine 6-phosphate
-
-
-
r
N-acetyl-alpha-D-glucosamine 1-phosphate
N-acetyl-D-glucosamine 6-phosphate
-
-
-
r
N-Acetylglucosamine 6-phosphate
?
-
the reaction is involved in the synthesis of active glycosyl intermediates in reticulo-endothelial tissues
-
-
?
N-Acetylglucosamine 6-phosphate
?
Coffea sp.
-
enzyme in the pathway of UDP-N-acetyl-D-glucosamine formation
-
-
?
N-Acetylglucosamine 6-phosphate
?
-
enzyme is involved in galactosamine synthesis from glucose during encystment, induced during encystment
-
-
?
N-Acetylglucosamine 6-phosphate
?
-
enzyme is involved in galactosamine synthesis from glucose during encystment, induced during encystment
-
-
?
additional information
?
-
-
one of the two last pathway-specific enzymes of hexosamine biosynthesis. The hexosamine pathway is regulated at the post-translational level during zoospore germination
-
-
?
additional information
?
-
the enzyme exhibits the function of phosphoglucomutase, EC 5.4.2.2, whose gene is lost in Trypanosoma brucei, together with phosphomannomutase, EC 5.4.2.8, producing D-glucose 1-phosphate from D-glucose 6-phosphate, kinetics, overview
-
-
?
additional information
?
-
-
the enzyme exhibits the function of phosphoglucomutase, EC 5.4.2.2, whose gene is lost in Trypanosoma brucei, together with phosphomannomutase, EC 5.4.2.8, producing D-glucose 1-phosphate from D-glucose 6-phosphate, kinetics, overview
-
-
?
additional information
?
-
the enzyme exhibits the function of phosphoglucomutase, EC 5.4.2.2, whose gene is lost in Trypanosoma brucei, together with phosphomannomutase, EC 5.4.2.8, producing D-glucose 1-phosphate from D-glucose 6-phosphate, kinetics, overview
-
-
?
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(3aR,5R,6S,7R,7aR)-5-(hydroxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]oxazole-6,7-diol
-
2,5:4,8-dianhydro-1,3-dideoxy-9-O-phosphono-D-erythro-L-gulo-nonitol
-
2-acetamido-1,5-anhydro-2,6,7-trideoxy-7-phosphono-D-gluco-heptitol
-
2-acetamido-1,5-anhydro-2,6-dideoxy-6-(sulfoamino)-D-glucitol
-
2-acetamido-1,5-anhydro-2,6-dideoxy-6-phosphono-D-glucitol
-
2-acetamido-1,5-anhydro-2,6-dideoxy-6-sulfo-D-glucitol
-
2-acetamido-1,5-anhydro-2-deoxy-6-O-phosphono-D-glucitol
-
2-acetamido-1,5-anhydro-2-deoxy-6-O-sulfo-D-glucitol
-
2-acetamido-1,5-anhydro-2-deoxy-D-glucitol
-
2-acetamido-2-deoxy-6-O-sulfo-D-glucopyranose
-
2-acetamido-2-deoxy-N-phosphono-6-O-phosphono-D-glucopyranosylamine
-
Be2+
-
0.02 mM in presence of 1 mM Mg2+, complete inhibition
Cd2+
-
0.5 mM in presence of 1 mM Mg2+, complete inhibition
Cu2+
-
0.5 mM in presence of 1 mM Mg2+, complete inhibition
D-glucose 1-phosphate
competitive inhibition
D-glucose 6-phosphate
competitive inhibition
Mn2+
-
1 mM in presence of 1 mM Mg2+, complete inhibition
Zn2+
-
0.5 mM in presence of 1 mM Mg2+, complete inhibition
[(3aR,5R,6S,7R,7aR)-6,7-dihydroxy-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]oxazol-5-yl]methyl phosphate
-
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malfunction
loss-of-function mutations in the nst gene, which encodes PGM3, block fibroblast growth factor signaling during embryonic mesoderm and tracheal development. In nst mutants with an 80% reduction in the amount of UDP-GlcNAc, O-GlcNAcylation is compromised. Embryos maternally and zygotically mutant for nst exhibit defects in mesoderm layer formation during gastrulation that are similar to those observed in embryos with mutations in the gene encoding the fibroblast growth factor receptor Heartless (Htl). Zygotic nst mutants (nstZ) exhibit normal dorsal mesoderm differentiation, embryos homozygous for the hypomorphic htlYY262 allele show a reduction in dorsal mesoderm. Phenotypes, overview. Dof is the critical component in MAPK activation affected in nst mutants
metabolism
Nst acts downstream of fibroblast growth factor receptor signaling
evolution
the enzyme belongs to the alpha-D-phosphohexomutase superfamily of enzymes
evolution
-
the enzyme belongs to the alpha-D-phosphohexomutase superfamily of enzymes
-
physiological function
the enzyme is essential for parasite growth. It takes over the function of phosphoglucomutase, EC 5.4.2.2, whose gene is lost in Trypanosoma brucei, together with phosphomannomutase, EC 5.4.2.8, producing D-glucose 1-phosphate from D-glucose 6-phosphate, kinetics, overview
physiological function
the enzyme is required for normal cellular levels of UDP-GlcNAc and essential in UDP-GlcNAc biosynthesis, and for fibroblast growth factor signaling in early embryos. Role for Nst in fibroblast growth factor receptor Heartless (Htl) signaling
physiological function
-
the enzyme is essential for parasite growth. It takes over the function of phosphoglucomutase, EC 5.4.2.2, whose gene is lost in Trypanosoma brucei, together with phosphomannomutase, EC 5.4.2.8, producing D-glucose 1-phosphate from D-glucose 6-phosphate, kinetics, overview
-
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Macechko, P.T.; Steimle, P.A.; Lindmark, D.G.; Erlandsen, S.L.; Jarroll, E.L.
Galactosamine-synthesizing enzymes are induced when Giardia encysts
Mol. Biochem. Parasitol.
56
301-310
1992
Giardia intestinalis, Giardia intestinalis MR4
brenda
Cheng, P.W.; Carlson, D.M.
Mechanism of phosphoacetylglucosamine mutase
J. Biol. Chem.
254
8353-8357
1979
Sus scrofa
brenda
Heptinstall, J.; Ward, P.J.; Hancock, I.C.
The enzymic synthesis of beta-[32P]UDP-N-acetylglucosamine
Anal. Biochem.
91
158-165
1978
Neurospora crassa
brenda
Selitrennikoff, C.P.; Sonneborn, D.R.
The last two pathway-specific enzyme activities of hexosamine biosynthesis are present in Blastocladiella emersonii zoospores prior to germination
Biochim. Biophys. Acta
451
408-416
1976
Blastocladiella emersonii
brenda
Mendicino, J.; Rao, A.K.
Regulation of the synthesis of nucleoside diphosphate sugars in reticulo-endothelial tissues
Eur. J. Biochem.
51
547-556
1975
Bos taurus, Meleagris gallopavo
brenda
Fernandez-Sorensen, A.; Carlson, D.M.
Purification and properties of phosphoglucosamine mutase
J. Biol. Chem.
246
3485-3493
1971
Sus scrofa
brenda
Reissig, J.L.; Leloir, L.F.
Phosphoacetylglucosamine mutase from Neurospora
Methods Enzymol.
8
175-178
1966
Neurospora crassa
-
brenda
Carlson, D.M.
Phosphoacetylglucosamine mutase from pig submaxillary gland
Methods Enzymol.
8
179-182
1966
Sus scrofa
-
brenda
Leloir, L.F.; Cardini, C.E.
Enzymes acting on glucosamine phosphates
Biochim. Biophys. Acta
20
33-42
1956
Sus scrofa
brenda
Veiga, L.A.
UDP-N-Acetyl-D-glucosamine biosynthesis in coffee leaves
Arq. Biol. Tecnol. (Curitiba)
32
377-390
1989
Coffea sp.
-
brenda
Mio, T.; Yamada-Okabe, T.; Arisawa, M.; Yamada-Okabe, H.
Functional cloning and mutational analysis of the human cDNA for phosphoacetylglucosamine mutase: identification of the amino acid residues essential for the catalysis
Biochim. Biophys. Acta
1492
369-376
2000
Homo sapiens (O95394), Homo sapiens, Candida albicans (Q9P4V2), Candida albicans
brenda
Kato, N.; Mueller, C.R.; Wessely, V.; Lan, Q.; Christensen, B.M.
Aedes aegypti phosphohexomutases and uridine diphosphate-hexose pyrophosphorylases: comparison of primary sequences, substrate specificities and temporal transcription
Insect Mol. Biol.
14
615-624
2005
Aedes aegypti (Q58I85), Aedes aegypti
brenda
Nishitani, Y.; Maruyama, D.; Nonaka, T.; Kita, A.; Fukami, T.A.; Mio, T.; Yamada-Okabe, H.; Yamada-Okabe, T.; Miki, K.
Purification, crystallization and preliminary X-ray diffraction studies of N-acetylglucosamine-phosphate mutase from Candida albicans
Acta Crystallogr. Sect. F
62
419-421
2006
Candida albicans
brenda
Nishitani, Y.; Maruyama, D.; Nonaka, T.; Kita, A.; Fukami, T.A.; Mio, T.; Yamada-Okabe, H.; Yamada-Okabe, T.; Miki, K.
Crystal structures of N-acetylglucosamine-phosphate mutase, a member of the alpha-D-phosphohexomutase superfamily, and its substrate and product complexes
J. Biol. Chem.
281
19740-19747
2006
Candida albicans (Q9P4V2), Candida albicans
brenda
Bandini, G.; Marino, K.; Guether, M.L.; Wernimont, A.K.; Kuettel, S.; Qiu, W.; Afzal, S.; Kelner, A.; Hui, R.; Ferguson, M.A.
Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase
Mol. Microbiol.
85
513-534
2012
Trypanosoma brucei (F4NCC3), Trypanosoma brucei, Trypanosoma brucei 427 (F4NCC3)
brenda
Mariappa, D.; Sauert, K.; Marino, K.; Turnock, D.; Webster, R.; van Aalten, D.M.; Ferguson, M.A.; Mueller, H.A.
Protein O-GlcNAcylation is required for fibroblast growth factor signaling in Drosophila
Sci. Signal.
4
ra89
2011
Drosophila melanogaster (Q9VTZ4)
brenda
Paiotta, A.; D'Orazio, G.; Palorini, R.; Ricciardiello, F.; Zoia, L.; Votta, G.; De Gioia, L.; Chiaradonna, F.; La Ferla, B.
Design, synthesis, and preliminary biological evaluation of GlcNAc-6P analogues for the modulation of phosphoacetylglucosamine mutase 1 (AGM1/PGM3)
Eur. J. Org. Chem.
2018
1946-1952
2018
Candida albicans (Q9P4V2)
-
brenda
Jia, X.; Kang, J.; Yin, H.
A simple and rapid method for measuring alpha-D-phosphohexomutases activity by using anion-exchange chromatography coupled with an electrochemical detector
PeerJ
4
e1517
2016
Arabidopsis thaliana
brenda