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Information on EC 5.3.3.9 - prostaglandin-A1 DELTA-isomerase
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5.3.3.9 prostaglandin-A1 DELTA-isomeraseIUBMB Comments
Interconverts prostaglandin A1 and prostaglandin C1.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
prostaglandin a isomerase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Isomerase, prostaglandin A1DELTA-
-
-
-
-
PGA isomerase
-
-
-
-
Prostaglandin A isomerase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate = (13E)-(15S)-15-hydroxy-9-oxoprosta-11,13-dienoate
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
intramolecular oxidoreduction
-
-
-
-
isomerization
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
(13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate DELTA10-DELTA11-isomerase
Interconverts prostaglandin A1 and prostaglandin C1.
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CAS REGISTRY NUMBER
COMMENTARY
9055-01-0
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
i.e. prostaglandin B1
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
i.e. prostaglandin B1
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
i.e. prostaglandin B1
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
i.e. prostaglandin B1
?
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
-
?
(5Z,13E)-(15S)-15-Hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid
?
-
i.e. prostaglandin A2
-
-
?
(5Z,13E)-(15S)-15-Hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid
?
-
i.e. prostaglandin A2
-
-
?
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
8 - 9
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6 - 10
-
pH 6.0: about 30% of maximal activity, pH 10.0: about 35% of maximal activity
6.5 - 10
-
pH 6.5: about 35% of maximal activity, pH 9.5-10.0: maximal activity
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
no activity in Bos taurus
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
50
60
70
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
10% loss of activity after dialysis
loss of activity after pepsin digestion
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
partial
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jones, R.L.
A prostaglandin isomerase in cat plasma
Biochem. J.
119
64P-65P
1970
Felis catus
brenda
Polet, H.; Levine, L.
Serum prostaglandin A1 isomerase
Biochem. Biophys. Res. Commun.
45
1169-1176
1971
Oryctolagus cuniculus, Equus caballus, Felis catus, Homo sapiens, Platyrrhini, Mus musculus, no activity in Bos taurus, Rattus norvegicus
brenda
Jones, R.L.; Cammock, S.; Horton, E.W.
Partial purification and properties of cat plasma prostaglanin A isomerase
Biochim. Biophys. Acta
280
588-601
1972
Canis lupus familiaris, Oryctolagus cuniculus, Felis catus, no activity in Bos taurus, Rattus norvegicus, Sus scrofa
brenda
Jones, R.L.; Cammock, S.
Purification, properties, and biological significance of prostaglandin A isomerase
Adv. Biosci.
9
61-70
1972
Canis lupus familiaris, Oryctolagus cuniculus, Felis catus, Rattus norvegicus, Sus scrofa
-
brenda
Ho, P.P.K.; Towner, R.D.; Sullivan, H.R.
Purification of prostaglandin A isomerase from rabbit serum
Prep. Biochem.
4
257-271
1974
Oryctolagus cuniculus
brenda
Polet, H.; Levine, L.
Metabolism of prostaglandins E, A, and C in serum
J. Biol. Chem.
250
351-357
1975
Canis lupus familiaris, Cavia porcellus, Oryctolagus cuniculus, Felis catus, Ovis aries, Homo sapiens, Mus musculus, no activity in Bos taurus, no activity in Gallus gallus, Rattus norvegicus, Sus scrofa
brenda
Polet, H.; Levine, L.
Partial purification and characterization of prostaglandin A isomerase from rabbit serum
Arch. Biochem. Biophys.
168
96-103
1975
Oryctolagus cuniculus
brenda
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