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D-sedoheptulose 7-phosphate
D-glycero-alpha,beta-D-manno-heptose 7-phosphate
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
additional information
?
-
the gmhA gene product is essential for the expression of wild-type lipooligosaccharide by this pathogen
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-alpha,beta-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-alpha,beta-D-manno-heptose 7-phosphate
first step of the biosynthesis of the inner core lipopolysaccharide precursor, ADP-L-glycero-D-manno-heptose
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-alpha,beta-D-manno-heptose 7-phosphate
synthesis of ADP-D-beta-D-heptose in Escherichia coli requires three proteins, GmhA (sedoheptulose 7-phosphate isomerase), HldE (bifunctional D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase), and GmhB (D,D-heptose 1,7-bisphosphate phosphatase)
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
r
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
the enzyme is involved in the biosynthesis of nucleotide-activated heptose
-
-
r
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
-
r
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
first committed step in the formation of ADP-heptose
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
it is postulated that GmhA acts through an enediol-intermediate isomerase mechanism
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
first committed step in the formation of ADP-heptose
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
it is postulated that GmhA acts through an enediol-intermediate isomerase mechanism
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
D-sedoheptulose 7-phosphate
D-glycero-alpha,beta-D-manno-heptose 7-phosphate
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
additional information
?
-
the gmhA gene product is essential for the expression of wild-type lipooligosaccharide by this pathogen
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-alpha,beta-D-manno-heptose 7-phosphate
first step of the biosynthesis of the inner core lipopolysaccharide precursor, ADP-L-glycero-D-manno-heptose
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-alpha,beta-D-manno-heptose 7-phosphate
synthesis of ADP-D-beta-D-heptose in Escherichia coli requires three proteins, GmhA (sedoheptulose 7-phosphate isomerase), HldE (bifunctional D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase), and GmhB (D,D-heptose 1,7-bisphosphate phosphatase)
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
the enzyme is involved in the biosynthesis of nucleotide-activated heptose
-
-
r
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
-
r
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
first committed step in the formation of ADP-heptose
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
first committed step in the formation of ADP-heptose
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
D-sedoheptulose 7-phosphate
D-glycero-D-manno-heptose 7-phosphate
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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0.3 - 1.2
D-sedoheptulose 7-phosphate
0.3
D-sedoheptulose 7-phosphate
mutant enzyme D61A, in 20 mM HEPES, pH 8.0, 10 mM MgCl2, 10 mM KCl, at 37°C
0.4
D-sedoheptulose 7-phosphate
wild type enzyme, in 20 mM HEPES, pH 8.0, 10 mM MgCl2, 10 mM KCl, at 37°C
0.5
D-sedoheptulose 7-phosphate
pH 8.0, mutant enzyme R69Q
0.5
D-sedoheptulose 7-phosphate
pH not specified in the publication, temperature not specified in the publication
0.7
D-sedoheptulose 7-phosphate
mutant enzyme H64Q, in 20 mM HEPES, pH 8.0, 10 mM MgCl2, 10 mM KCl, at 37°C
0.9
D-sedoheptulose 7-phosphate
pH 8.0, wild-type enzyme
1.2
D-sedoheptulose 7-phosphate
pH 8.0, mutant enzyme H61Q
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.02 - 33.1
D-sedoheptulose 7-phosphate
0.02
D-sedoheptulose 7-phosphate
mutant enzyme D61A, in 20 mM HEPES, pH 8.0, 10 mM MgCl2, 10 mM KCl, at 37°C
0.07
D-sedoheptulose 7-phosphate
mutant enzyme H64Q, in 20 mM HEPES, pH 8.0, 10 mM MgCl2, 10 mM KCl, at 37°C
0.23
D-sedoheptulose 7-phosphate
pH 8.0, mutant enzyme H61Q
0.44
D-sedoheptulose 7-phosphate
pH 8.0, wild-type enzyme
0.45
D-sedoheptulose 7-phosphate
pH 8.0, mutant enzyme R69Q
0.5
D-sedoheptulose 7-phosphate
wild type enzyme, in 20 mM HEPES, pH 8.0, 10 mM MgCl2, 10 mM KCl, at 37°C
33.1
D-sedoheptulose 7-phosphate
pH not specified in the publication, temperature not specified in the publication
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.07 - 71.9
D-sedoheptulose 7-phosphate
0.07
D-sedoheptulose 7-phosphate
mutant enzyme D61A, in 20 mM HEPES, pH 8.0, 10 mM MgCl2, 10 mM KCl, at 37°C
0.1
D-sedoheptulose 7-phosphate
mutant enzyme H64Q, in 20 mM HEPES, pH 8.0, 10 mM MgCl2, 10 mM KCl, at 37°C
0.2
D-sedoheptulose 7-phosphate
pH 8.0, mutant enzyme H61Q
0.5
D-sedoheptulose 7-phosphate
pH 8.0, wild-type enzyme
0.9
D-sedoheptulose 7-phosphate
pH 8.0, mutant enzyme R69Q
1.2
D-sedoheptulose 7-phosphate
wild type enzyme, in 20 mM HEPES, pH 8.0, 10 mM MgCl2, 10 mM KCl, at 37°C
71.9
D-sedoheptulose 7-phosphate
pH not specified in the publication, temperature not specified in the publication
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Kim, M.S.; Shin, D.H.
A preliminary X-ray study of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei
Acta Crystallogr. Sect. F
65
1110-1112
2009
Burkholderia pseudomallei
brenda
Bauer, B.A.; Stevens, M.K.; Hansen, E.J.
Involvement of the Haemophilus ducreyi gmhA gene product in lipooligosaccharide expression and virulence
Infect. Immun.
66
4290-4298
1998
[Haemophilus] ducreyi (O87340)
brenda
Darby, C.; Ananth, S.L.; Tan, L.; Hinnebusch, B.J.
Identification of gmhA, a Yersinia pestis gene required for flea blockage, by using a Caenorhabditis elegans biofilm system
Infect. Immun.
73
7236-7242
2005
Yersinia pestis
brenda
Brooke, J.S.; Valvano, M.A.
Molecular cloning of the Haemophilus influenzae gmhA (lpcA) gene encoding a phosphoheptose isomerase required for lipooligosaccharide biosynthesis
J. Bacteriol.
178
3339-3341
1996
Haemophilus influenzae (P45093), Haemophilus influenzae
brenda
Kneidinger, B.; Marolda, C.; Graninger, M.; Zamyatina, A.; McArthur, F.; Kosma, P.; Valvano, M.A.; Messner, P.
Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli
J. Bacteriol.
184
363-369
2002
Escherichia coli (P63224), Aneurinibacillus thermoaerophilus (Q9AGY7)
brenda
Brooke, J.S.; Valvano, M.A.
Biosynthesis of inner core lipopolysaccharide in enteric bacteria identification and characterization of a conserved phosphoheptose isomerase
J. Biol. Chem.
271
3608-3614
1996
Escherichia coli (P63224), Escherichia coli
brenda
Kneidinger, B.; Graninger, M.; Puchberger, M.; Kosma, P.; Messner, P.
Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose
J. Biol. Chem.
276
20935-20944
2001
Aneurinibacillus thermoaerophilus (Q9AGY7)
brenda
Taylor, P.L.; Blakely, K.M.; de Leon, G.P.; Walker, J.R.; McArthur, F.; Evdokimova, E.; Zhang, K.; Valvano, M.A.; Wright, G.D.; Junop, M.S.
Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants
J. Biol. Chem.
283
2835-2845
2008
Escherichia coli (P63224), Escherichia coli, Pseudomonas aeruginosa (Q9HVZ0), Pseudomonas aeruginosa
brenda
Valvano, M.A.; Messner, P.; Kosma, P.
Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides
Microbiology
148
1979-1989
2002
Neisseria meningitidis (P0A0Y5), Neisseria meningitidis (P0A0Y6), Haemophilus influenzae (P45093), Salmonella enterica subsp. enterica serovar Typhimurium (P63223), Escherichia coli (P63224), Mycobacterium tuberculosis (P9WGG1), Yersinia pestis (Q8ZBY7), Burkholderia pseudomallei (Q93UJ2), Clostridium acetobutylicum (Q97EQ4), Aneurinibacillus thermoaerophilus (Q9AGY7), Burkholderia mallei (Q9AI36), Pseudomonas aeruginosa (Q9HVZ0), Vibrio cholerae (Q9KPY2), Campylobacter jejuni (Q9PMN3), Campylobacter jejuni (Q9PNE6), Helicobacter pylori J99 (Q9ZKZ1), Mycobacterium tuberculosis H37Rv (P9WGG1)
brenda
Umamaheswari, A.; Pradhan, D.; Hemanthkumar, M.
Identification of potential Leptospira phosphoheptose isomerase inhibitors through virtual high-throughput screening
Genomics Proteomics Bioinformatics
8
246-255
2010
Leptospira interrogans (Q72RC1)
brenda
Harmer, N.J.
The structure of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei reveals a zinc binding site at the heart of the active site
J. Mol. Biol.
400
379-392
2010
Burkholderia pseudomallei (Q93UJ2), Burkholderia pseudomallei, Burkholderia pseudomallei K96243 (Q93UJ2)
brenda
Durka, M.; Tikad, A.; Perion, R.; Bosco, M.; Andaloussi, M.; Floquet, S.; Malacain, E.; Moreau, F.; Oxoby, M.; Gerusz, V.; Vincent, S.P.
Systematic synthesis of inhibitors of the two first enzymes of the bacterial heptose biosynthetic pathway: towards antivirulence molecules targeting lipopolysaccharide biosynthesis
Chemistry
17
11305-11313
2011
Escherichia coli
brenda
Yu, C.K.; Wang, C.J.; Chew, Y.; Wang, P.C.; Yin, H.S.; Kao, M.C.
Functional characterization of Helicobacter pylori 26695 sedoheptulose 7-phosphate isomerase encoded by hp0857 and its association with lipopolysaccharide biosynthesis and adhesion
Biochem. Biophys. Res. Commun.
477
794-800
2016
Helicobacter pylori (O25528), Helicobacter pylori, Helicobacter pylori 26695 (O25528), Helicobacter pylori 26695
brenda