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2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
7,8-dihydroneopterin 3'-phosphate + H2O
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
additional information
?
-
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
7,8-dihydroneopterin 3'-phosphate + H2O
-
-
-
?
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
7,8-dihydroneopterin 3'-phosphate + H2O
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
ir
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
ir
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
ir
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
mechanism
enolamine is the first product, which then tautomerizes to the alpha-amino ketone
r
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
structure of the indole-3-glycerol-phosphate synthetase/PRA isomerase complex, 2 well-defined functional domains: N-terminal indole-3-glycerol-phosphate synthetase, residues 1-255, and C-terminal PRA isomerase, residues 256-452, with limited noncovalent contacts between the domains, the two reactions are catalyzed independently from each other
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
structure of the indole-3-glycerol-phosphate synthetase/PRA isomerase complex, 2 well-defined functional domains: N-terminal indole-3-glycerol-phosphate synthetase, residues 1-255, and C-terminal PRA isomerase, residues 256-452, with limited noncovalent contacts between the domains, the two reactions are catalyzed independently from each other
-
ir
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
structure of the indole-3-glycerol-phosphate synthetase/PRA isomerase complex, 2 well-defined functional domains: N-terminal indole-3-glycerol-phosphate synthetase, residues 1-255, and C-terminal PRA isomerase, residues 256-452, with limited noncovalent contacts between the domains, the two reactions are catalyzed independently from each other
-
ir
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
ir
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
involved in tryptophan biosynthesis from chorismate
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
ir
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
ir
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
mechanism
enolamine is the first product, which then tautomerizes to the alpha-amino ketone
r
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
thermodynamic equilibrium strongly favors the product
enolamine is the first product, which then tautomerizes to the alpha-amino ketone
r
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
mechanism
enolamine is the first product, which then tautomerizes to the alpha-amino ketone
r
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
thermodynamic equilibrium strongly favors the product
enolamine is the first product, which then tautomerizes to the alpha-amino ketone
r
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
ir
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
ir
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
ir
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
enzyme structure
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
enzyme structure
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
high catalytic efficiency
-
ir
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
high catalytic efficiency
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
high catalytic efficiency
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
reaction mechanism involving general acid-base catalysis and a Schiff base intermediate, Cys-7 and Asp-126 are important for the reaction
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
imidazole glycerol phosphate synthase mutant enzyme forms that generate phosphoribosylanthranilate isomerase activity: D130V, D130T, D130P. Mutant form of EC 5.3.1.6 that generate phosphoribosylanthranilate isomerase activity: D127V, D127K, D127T, D127G, D127F, D127V/T164H
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
ir
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
additional information
?
-
besides phosphoribosyl anthranilate isomerase activity, enzyme is involved in folate synthesis, reaction of EC 4.2.1.160
-
-
?
additional information
?
-
besides phosphoribosyl anthranilate isomerase activity, enzyme is involved in folate synthesis, reaction of EC 4.2.1.160
-
-
?
additional information
?
-
-
the enzyme is essential for cell proliferation in the absence of tryptophan
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
7,8-dihydroneopterin 3'-phosphate + H2O
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
additional information
?
-
-
the enzyme is essential for cell proliferation in the absence of tryptophan
-
-
?
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
7,8-dihydroneopterin 3'-phosphate + H2O
-
-
-
?
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
7,8-dihydroneopterin 3'-phosphate + H2O
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
involved in tryptophan biosynthesis from chorismate
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
third step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
-
-
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
involved in tryptophan biosynthesis from chorismate
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
fourth step in tryptophan biosynthesis
-
?
N-(5-phospho-beta-D-ribosyl)anthranilate
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
involved in tryptophan biosynthesis from chorismate
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.00028 - 1.3
N-(5-phospho-beta-D-ribosyl)anthranilate
additional information
additional information
-
0.00028
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, dimer
0.00028
N-(5-phospho-beta-D-ribosyl)anthranilate
pH 7.5, 25°C, dimer
0.00028
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, dimer
0.00028
N-(5-phospho-beta-D-ribosyl)anthranilate
-
wild type enzyme, in 50 mM HEPES, pH 7.5, at 25°C
0.00039
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 45°C, dimer
0.00073
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 60°C, dimer
0.00103
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 80°C, dimer
0.0032
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, recombinant xPRAI, expressed in Escherichia coli
0.004
N-(5-phospho-beta-D-ribosyl)anthranilate
PriA, PRA isomerase activity
0.004 - 0.005
N-(5-phospho-beta-D-ribosyl)anthranilate
-
30°C
0.0047
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5
0.0047
N-(5-phospho-beta-D-ribosyl)anthranilate
-
25°C, monomeric domain PRAI[ML256-452]
0.0049
N-(5-phospho-beta-D-ribosyl)anthranilate
-
-
0.0049
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5
0.0049
N-(5-phospho-beta-D-ribosyl)anthranilate
-
25°C, bifunctional IGPS:PRAI
0.005
N-(5-phospho-beta-D-ribosyl)anthranilate
PriA, PRA isomerase activity
0.007
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 20°C
0.0083
N-(5-phospho-beta-D-ribosyl)anthranilate
PriA mutant R19A, PRA isomerase activity
0.018
N-(5-phospho-beta-D-ribosyl)anthranilate
-
mutant enzyme D130V/D176V, in 50 mM HEPES, pH 7.5, at 25°C
0.019
N-(5-phospho-beta-D-ribosyl)anthranilate
-
mutant enzyme D127V/D173V, in 50 mM HEPES, pH 7.5, at 25°C
0.026
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, D127G, mutant form of EC 5.3.1.6
0.03
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, D127K, mutant form of EC 5.3.1.6
0.036
N-(5-phospho-beta-D-ribosyl)anthranilate
-
mutant enzyme D127V/D169V, in 50 mM HEPES, pH 7.5, at 25°C
0.036
N-(5-phospho-beta-D-ribosyl)anthranilate
-
mutant enzyme D169V, in 50 mM HEPES, pH 7.5, at 25°C
0.04
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, D130P, mutant form of imidazole glycerol phosphate synthase
0.041
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, D127F, mutant form of EC 5.3.1.6
0.043
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, D127T, mutant form of EC 5.3.1.6
0.045
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, D130T, mutant form of imidazole glycerol phosphate synthase
0.051
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, D127V/T164H, mutant form of EC 5.3.1.6
0.053
N-(5-phospho-beta-D-ribosyl)anthranilate
-
mutant enzyme D173V, in 50 mM HEPES, pH 7.5, at 25°C
0.074
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, D127V, mutant form of EC 5.3.1.6
0.074
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, D130V, mutant form of imidazole glycerol phosphate synthase
0.074
N-(5-phospho-beta-D-ribosyl)anthranilate
-
mutant enzyme D127V, in 50 mM HEPES, pH 7.5, at 25°C
0.074
N-(5-phospho-beta-D-ribosyl)anthranilate
-
mutant enzyme D130V, in 50 mM HEPES, pH 7.5, at 25°C
0.28
N-(5-phospho-beta-D-ribosyl)anthranilate
-
in 50 mM HEPES, pH 7.5 at 25°C
1.3
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.6
additional information
additional information
-
-
-
additional information
additional information
-
increasing the pH from 7.5 to 8.6 increases the Km
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.000092 - 130
N-(5-phospho-beta-D-ribosyl)anthranilate
additional information
additional information
-
values for PRAI variants
-
0.000092
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, D130T, mutant form of imidazole glycerol phosphate synthase
0.00018
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, D130V, mutant form of imidazole glycerol phosphate synthase
0.000183
N-(5-phospho-beta-D-ribosyl)anthranilate
-
mutant enzyme D130V, in 50 mM HEPES, pH 7.5, at 25°C
0.00022
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, D130P, mutant form of imidazole glycerol phosphate synthase
0.000283
N-(5-phospho-beta-D-ribosyl)anthranilate
-
mutant enzyme D173V, in 50 mM HEPES, pH 7.5, at 25°C
0.0012
N-(5-phospho-beta-D-ribosyl)anthranilate
-
mutant enzyme D130V/D176V, in 50 mM HEPES, pH 7.5, at 25°C
0.0013
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, D127G, mutant form of EC 5.3.1.6
0.0017
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, D127K, mutant form of EC 5.3.1.6
0.0023
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, D127F, mutant form of EC 5.3.1.6
0.0027
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, D127T, mutant form of EC 5.3.1.6
0.0086
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, D127V, mutant form of EC 5.3.1.6
0.009
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, D127V/T164H, mutant form of EC 5.3.1.6
0.009
N-(5-phospho-beta-D-ribosyl)anthranilate
-
mutant enzyme D127V, in 50 mM HEPES, pH 7.5, at 25°C
0.028
N-(5-phospho-beta-D-ribosyl)anthranilate
-
mutant enzyme D169V, in 50 mM HEPES, pH 7.5, at 25°C
0.032
N-(5-phospho-beta-D-ribosyl)anthranilate
-
mutant enzyme D127V/D173V, in 50 mM HEPES, pH 7.5, at 25°C
0.522
N-(5-phospho-beta-D-ribosyl)anthranilate
-
mutant enzyme D127V/D169V, in 50 mM HEPES, pH 7.5, at 25°C
1.4
N-(5-phospho-beta-D-ribosyl)anthranilate
PriA mutant R19A, PRA isomerase activity
3.4
N-(5-phospho-beta-D-ribosyl)anthranilate
PriA, PRA isomerase activity
3.7
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, dimer
3.7
N-(5-phospho-beta-D-ribosyl)anthranilate
pH 7.5, 25°C, dimer
3.7
N-(5-phospho-beta-D-ribosyl)anthranilate
-
wild type enzyme, in 50 mM HEPES, pH 7.5, at 25°C
3.7
N-(5-phospho-beta-D-ribosyl)anthranilate
-
in 50 mM HEPES, pH 7.5 at 25°C
12
N-(5-phospho-beta-D-ribosyl)anthranilate
PriA, PRA isomerase activity
13.5
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 45°C, dimer
32
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5
32
N-(5-phospho-beta-D-ribosyl)anthranilate
-
25°C, monomeric domain PRAI[ML256-452]
38.5
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 60°C, dimer
39
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 20°C
40
N-(5-phospho-beta-D-ribosyl)anthranilate
-
25°C
40
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C
40
N-(5-phospho-beta-D-ribosyl)anthranilate
-
bifunctional IGPS:PRAI
50
N-(5-phospho-beta-D-ribosyl)anthranilate
-
-
50 - 60
N-(5-phospho-beta-D-ribosyl)anthranilate
-
30°C
69
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 25°C, recombinant xPRAI, expressed in E. coli
130
N-(5-phospho-beta-D-ribosyl)anthranilate
-
pH 7.5, 80°C, dimer
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Mut_L2_FBPA
loop exchange in the PRAI-LoxP scaffold, position beta/alpha loop 2, sequence of loop SNGGASFIAGKGVKSDVPQ, fructose-bisphosphate aldolase, EC 4.1.2.13
Mut_L2_MR
loop exchange in the PRAI-LoxP scaffold, position beta/alpha loop 2, sequence of loop GYPAL, mandelate racemase, EC 5.1.2.2
Mut_L2_PRAI_WT
loop exchange in the PRAI-LoxP scaffold, position beta/alpha loop 2, sequence of loop VATSPRCVN, phosphoribosylanthranilate isomerase, EC 5.3.1.24
Mut_L2_Ure
loop exchange in the PRAI-LoxP scaffold, position beta/alpha loop 2, sequence of loop GGTGPAAGTHATTCTPG, urease, EC 3.5.1.5
Mut_L4_ADA
loop exchange in the PRAI-LoxP scaffold, position beta/alpha loop 4, sequence of loop GDELGFPGSLF, adenosine diaminase, EC 3.5.4.4
Mut_L4_alphaTS
loop exchange in the PRAI-LoxP scaffold, position beta/alpha loop 4, sequence of loop DVPVQQS, tryptophan synthase, EC 4.2.1.20
Mut_L4_DHDPS
loop exchange in the PRAI-LoxP scaffold, position beta/alpha loop 4, sequence of loop PYYNRPS, dihydrodipicolinate synthase, EC 4.2.1.52
Mut_L4_FBPA
loop exchange in the PRAI-LoxP scaffold, position beta/alpha loop 4, sequence of loop DLSEES, fructose-bisphosphate aldolase, EC 4.1.2.13
Mut_L4_MR
loop exchange in the PRAI-LoxP scaffold, position beta/alpha loop 4, sequence of loop EPTLEHD, mandelate racemase, EC 5.1.2.2
Mut_L4_PBGS
loop exchange in the PRAI-LoxP scaffold, position beta/alpha loop 4, sequence of loop AAMDG, porphobilinogen synthase, EC 4.2.1.24
Mut_L4_PRAI_WT
loop exchange in the PRAI-LoxP scaffold, position beta/alpha loop 4, sequence of loop GNEE, phosphoribosylanthranilate isomerase, EC 5.3.1.24
Mut_L4_TPS
loop exchange in the PRAI-LoxP scaffold, position beta/alpha loop 4, sequence of loop LGQEDLH, thiamine-phosphate diphosphorylase, EC 2.5.1.3
Mut_L4_Ure
loop exchange in the PRAI-LoxP scaffold, position beta/alpha loop 4, sequence of loop EDWGAT, urease, EC 3.5.1.5
Mut_L6_alphaTS
loop exchange in the PRAI-LoxP scaffold, position beta/alpha loop 6, sequence of loop SRAGVTGAENRAALP, tryptophan synthase, EC 4.2.1.20
Mut_L6_DHDPS
loop exchange in the PRAI-LoxP scaffold, position beta/alpha loop 6, sequence of loop TGNL, dihydrodipicolinate synthase, EC 4.2.1.52
Mut_L6_PBGS
loop exchange in the PRAI-LoxP scaffold, position beta/alpha loop 6, sequence of loop PAGAY, porphobilinogen synthase, EC 4.2.1.24
Mut_L6_PRAI_WT
loop exchange in the PRAI-LoxP scaffold, position beta/alpha loop 6, sequence of loop NGQGGSGQRFD, phosphoribosylanthranilate isomerase, EC 5.3.1.24
R139N
mutant, used for crystallization, steady-state Michaelis-Menten enzyme kinetic is studied
R19A
mutant, steady-state Michaelis-Menten enzyme kinetic is studied
S81T
mutant, steady-state Michaelis-Menten enzyme kinetic is studied
C7A
catalytically inactive mutant
D126N
mutant with drastically reduced activity
D127V
-
the mutant shows strongly reduced activity compared to the wild type enzyme
D127V/D169V
-
the mutant shows strongly reduced activity compared to the wild type enzyme
D127V/D173V
-
the mutant shows strongly reduced activity compared to the wild type enzyme
D130V
-
the mutant shows strongly reduced activity compared to the wild type enzyme
D130V/D176V
-
the mutant shows strongly reduced activity compared to the wild type enzyme
D169V
-
the mutant shows strongly reduced activity compared to the wild type enzyme
D173V
-
the mutant shows strongly reduced activity compared to the wild type enzyme
D126N/C7A
-
catalytically inactive double mutant
D126N/C7A
catalytically inactive double mutant
additional information
-
PAI deletion mutant trp6 shows abnormal growth and development, isolated from Wassilewskija ecotype, which contains 4 PAI isogenes, the only active isogene in trp6 is PAI2
additional information
insertion mutagenesis of TRP1 gene
additional information
-
insertion mutagenesis of TRP1 gene
additional information
-
insertion of the cleavage sequence of human cytomegalovirus, HCMV, protease, which is an attractive target for antiviral drug development because of its essential function in viral replication, the enzyme serves as substrate for the protease in the screening assay for small molecule inhibitors of the protease, coexpression of HCMV protease with the engineered Trp1p substrate in yeast cells results in site-specific cleavage and functional inactivation of the Trp1p enzyme, thereby leading to an arrest of cell proliferation, this growth arrest can be suppressed by the addition of validated HCMV protease inhibitors, overview
additional information
-
mutationally generated monomers of dimeric PRAI are as active as the dimer, but far more thermolabile, Pro-52/Phe-53 deletion mutant and mutants with multiple point mutations
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-
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