Reference on EC 4.6.1.12 - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Takagi, M.; Kuzuyama, T.; Kaneda, K.; Watanabe, H.; Dairi, T.; Seto, H.
Studies on the nonmevalonate pathway: Formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate from 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
Tetrahedron Lett.
41
3395-3398
2000
Escherichia coli, Escherichia coli (P62617)
-
Kishida, H.; Wada, T.; Unzai, S.; Kuzuyama, T.; Takagi, M.; Terada, T.; Shirouzu, M.; Yokoyama, S.; Tame, J.R.; Park, S.Y.
Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis
Acta Crystallogr. Sect. D
59
23-31
2003
Thermus thermophilus (Q8RQP5)
Ni, S.; Robinson, H.; Marsing, G.C.; Bussiere, D.E.; Kennedy, M.A.
Structure of 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase from Shewanella oneidensis at 1.6 ANG: identification of farnesyl pyrophosphate trapped in a hydrophobic cavity
Acta Crystallogr. Sect. D
D60
1949-1957
2004
Shewanella oneidensis, Shewanella oneidensis MR1
Rohdich, F.; Eisenreich, W.; Wungsintaweekul, J.; Hecht, S.; Schuhr, C.A.; Bacher, A.
Biosynthesis of terpenoids. 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF) from Plasmodium falciparum
Eur. J. Biochem.
268
3190-3197
2001
Plasmodium falciparum (P62368), Plasmodium falciparum
Campbell, T.L.; Brown, E.D.
Characterization of the depletion of 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase in Escherichia coli and Bacillus subtilis
J. Bacteriol.
184
5609-5618
2002
Escherichia coli
Richard, S.B.; Ferrer, J.L.; Bowman, M.E.; Lillo, A.M.; Tetzlaff, C.N.; Cane, D.E.; Noel, J.P.
Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway
J. Biol. Chem.
277
8667-8672
2002
Escherichia coli (P62617)
Gabrielsen, M.; Bond, C.S.; Hallyburton, I.; Hecht, S.; Bacher, A.; Eisenreich, W.; Rohdich, F.; Hunter, W.N.
Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis
J. Biol. Chem.
279
52753-52761
2004
Agrobacterium tumefaciens, Campylobacter jejuni, Escherichia coli (P62617), Escherichia coli
Steinbacher, S.; Kaiser, J.; Wungsintaweekul, J.; Hecht, S.; Eisenreich, W.; Gerhardt, S.; Bacher, A.; Rohdich, F.
Structure of 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids
J. Mol. Biol.
316
79-88
2002
Escherichia coli
Herz, S.; Wungsintaweekul, J.; Schuhr, C.A.; Hecht, S.; Lttgen, H.; Sagner, S.; Fellermeier, M.; Eisenreich, W.; Zenk, M.H.; Bacher, A.; Rohdich, F.
Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate
Proc. Natl. Acad. Sci. USA
97
2486-2490
2000
Escherichia coli (P62617), Escherichia coli
Kemp, L.E.; Bond, C.S.; Hunter, W.N.
Structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development
Proc. Natl. Acad. Sci. USA
99
6591-6596
2002
Escherichia coli (P62617), Escherichia coli
Lehmann, C.; Lim, K.; Toedt, J.; Krajewski, W.; Howard, A.; Eisenstein, E.; Herzberg, O.
Structure of 2C-methyl-D-erythrol-2,4-cyclodiphosphate synthase from Haemophilus influenzae: Activation by conformational transition
Proteins
49
135-138
2002
Haemophilus influenzae (P44815), Haemophilus influenzae
Sgraja, T.; Kemp, L.E.; Ramsden, N.; Hunter, W.N.
A double mutation of Escherichia coli 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase disrupts six hydrogen bonds with, yet fails to prevent binding of, an isoprenoid diphosphate
Acta Crystallogr. Sect. F
F61
625-629
2005
Escherichia coli
Kim, S.M.; Kuzuyama, T.
Cloning and characterization of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECS) gene from Ginkgo biloba
Plant Cell Rep.
8
829-835
2006
Ginkgo biloba (Q1EDG4)
-
Lherbet, C.; Pojer, F.; Richard, S.B.; Noel, J.P.; Poulter, C.D.
Absence of substrate channeling between active sites in the Agrobacterium tumefaciens IspDF and IspE enzymes of the methyl erythritol phosphate pathway
Biochemistry
45
3548-3553
2006
Agrobacterium tumefaciens
Illarionova, V.; Kaiser, J.; Ostrozhenkova, E.; Bacher, A.; Fischer, M.; Eisenreich, W.; Rohdich, F.
Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods
J. Org. Chem.
71
8824-8834
2006
Plasmodium sp.
Baumgartner, C.; Eberle, C.; Diederich, F.; Lauw, S.; Rohdich, F.; Eisenreich, W.; Bacher, A.
Structure-based design and synthesis of the first weak non-phosphate inhibitors for IspF, an enzyme in the non-mevalonate pathway of isoprenoid biosynthesis
Helv. Chim. Acta
90
1043-1068
2007
Escherichia coli (P62617)
-
Jin, H.; Gong, Y.; Guo, B.; Qiu, C.; Liu, D.; Miao, Z.; Sun, X.; Tang, K.
Isolation and characterization of a 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase gene from Taxus media
Mol. Biol.
40
914-921
2006
Taxus x media (A1X5Y0)
-
Hsieh, M.; Goodman, H.M.
Functional evidence for the involvement of Arabidopsis IspF homolog in the nonmevalonate pathway of plastid isoprenoid biosynthesis
Planta
223
779-784
2006
Arabidopsis thaliana
Calisto, B.M.; Perez-Gil, J.; Bergua, M.; Querol-Audi, J.; Fita, I.; Imperial, S.
Biosynthesis of isoprenoids in plants: Structure of the 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Arabidopsis thaliana. Comparison with the bacterial enzymes
Protein Sci.
16
2082-2088
2007
Arabidopsis thaliana (Q9CAK8), Arabidopsis thaliana
Sando, T.; Takeno, S.; Watanabe, N.; Okumoto, H.; Kuzuyama, T.; Yamashita, A.; Hattori, M.; Ogasawara, N.; Fukusaki, E.; Kobayashi, A.
Cloning and characterization of the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway genes of a natural-rubber producing plant, Hevea brasiliensis
Biosci. Biotechnol. Biochem.
72
2903-2917
2008
Hevea brasiliensis (A9ZN12), Hevea brasiliensis
Chen, J.; Xiao, Y.; Di, P.; Yu, X.; Chen, W.; Zhang, L.
Molecular cloning and characterization of a 2C-methyl-D: -erythritol 2,4-cyclodiphosphate synthase gene from Cephalotaxus harringtonia
Mol. Biol. Rep.
36
1749-1756
2008
Cephalotaxus harringtonia
Narayanasamy, P.; Eoh, H.; Crick, D.C.
Chemoenzymatic synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol: a substrate for IspE
Tetrahedron Lett.
49
4461-4463
2008
Mycobacterium tuberculosis, Mycobacterium tuberculosis Rv3582c
Battilana, J.; Costantini, L.; Emanuelli, F.; Sevini, F.; Segala, C.; Moser, S.; Velasco, R.; Versini, G.; Stella Grando, M.
The 1-deoxy-D: -xylulose 5-phosphate synthase gene co-localizes with a major QTL affecting monoterpene content in grapevine
Theor. Appl. Genet.
118
653-669
2009
Vitis vinifera x Vitis vinifera, Vitis vinifera x Vitis riparia
Geist, J.G.; Lauw, S.; Illarionova, V.; Illarionov, B.; Fischer, M.; Graewert, T.; Rohdich, F.; Eisenreich, W.; Kaiser, J.; Groll, M.; Scheurer, C.; Wittlin, S.; Alonso-Gomez, J.L.; Schweizer, W.B.; Bacher, A.; Diederich, F.
Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum
ChemMedChem
5
1092-1101
2010
Arabidopsis thaliana (Q9CAK8), Arabidopsis thaliana, Escherichia coli, Mycobacterium tuberculosis (P9WKG5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WKG5), Plasmodium falciparum (P62369), Plasmodium falciparum, Plasmodium falciparum NF54 (P62369)
Ramsden, N.L.; Buetow, L.; Dawson, A.; Kemp, L.A.; Ulaganathan, V.; Brenk, R.; Klebe, G.; Hunter, W.N.
A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy
J. Med. Chem.
52
2531-2542
2009
Escherichia coli (P62617), Escherichia coli
Liu, W.; Chen, M.; Yang, C.; Yang, Y.; Lan, X.; Liao, Z.
A new 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase gene from Taxus media: Cloning, characterization and functional complementation
J. Med. Plant Res.
3
395-402
2009
Taxus x media (D3G6G3)
-
Narayanasamy, P.; Eoh, H.; Brennan, P.J.; Crick, D.C.
Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF, a potential drug target
Chem. Biol.
17
117-122
2010
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Jung, Y.; Choi, J.; Sun, J.; Nou, I.; Cho, Y.; Kang, K.
Molecular and functional characterization of a Brmecp gene encoding 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Brassica rapa
J. Plant Biotechnol.
39
189-195
2012
Brassica rapa
-
Kumar, H.; Singh, K.; Kumar, S.
2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase from Stevia rebaudiana Bertoni is a functional gene
Mol. Biol. Rep.
39
10971-10978
2012
Stevia rebaudiana (Q0Q5B3), Stevia rebaudiana
Zheng, Y.; Chen, M.; Yang, C.; Ming, X.; Liu, X.; Lan, X.; Liao, Z.
Cloning and characterization of MECS and HDS genes from Rauvolfia verticillata
Plant OMICS
4
82-90
2011
Rauvolfia verticillata
-
Liu, Z.; Jin, Y.; Tao, Y.; Wang, G.
Crystal structure of IspF from Bacillus subtilis and absence of protein complex assembly amongst IspD/IspE/IspF enzymes in the MEP pathway
Biosci. Rep.
38
BSR20171370
2018
Bacillus subtilis (Q06756), Bacillus subtilis 168 (Q06756)
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